2023
The impact of ABO and RhD blood types on Babesia microti infection
Jajosky R, O’Bryan J, Spichler-Moffarah A, Jajosky P, Krause P, Tonnetti L. The impact of ABO and RhD blood types on Babesia microti infection. PLOS Neglected Tropical Diseases 2023, 17: e0011060. PMID: 36696414, PMCID: PMC9901808, DOI: 10.1371/journal.pntd.0011060.Peer-Reviewed Original ResearchConceptsB. microti infectionABO blood typeBabesia microti infectionMicroti infectionBlood donorsBlood typeDisease severityPlasmodium falciparum malaria patientsFalciparum malaria patientsHigher peak parasitemiaRed blood cell antigensType BImpact of ABOBlood cell antigensBlood type BMalaria patientsTransfusion strategyInfected donorsRhD blood typeSevere diseasePeak parasitemiaB antigensCell antigensPossible associationRhD antigen
2022
Animal models of the immunology and pathogenesis of human babesiosis
Kumar A, Kabra A, Igarashi I, Krause P. Animal models of the immunology and pathogenesis of human babesiosis. Trends In Parasitology 2022, 39: 38-52. PMID: 36470781, DOI: 10.1016/j.pt.2022.11.003.Peer-Reviewed Original ResearchConceptsAnimal modelsHuman babesiosisBabesia infectionImmunological mechanismsModerate diseaseOrgan dysfunctionPathologic responseDisease complicationsAsymptomatic infectionSevere diseaseAnimal studiesInfectionPathological processesDiseaseBabesiosisBabesia speciesAnimalsDomestic animalsComplicationsDysfunctionPathogenesisImmunology
2020
Management strategies for human babesiosis
Smith RP, Hunfeld KP, Krause PJ. Management strategies for human babesiosis. Expert Review Of Anti-infective Therapy 2020, 18: 625-636. PMID: 32268823, DOI: 10.1080/14787210.2020.1752193.Peer-Reviewed Original Research
2018
Human Babesiosis Caused by a Babesia crassa–Like Pathogen: A Case Series
Jia N, Zheng YC, Jiang JF, Jiang RR, Jiang BG, Wei R, Liu HB, Huo QB, Sun Y, Chu YL, Fan H, Chang QC, Yao NN, Zhang WH, Wang H, Guo DH, Fu X, Wang YW, Krause PJ, Song JL, Cao WC. Human Babesiosis Caused by a Babesia crassa–Like Pathogen: A Case Series. Clinical Infectious Diseases 2018, 67: 1110-1119. PMID: 29538646, DOI: 10.1093/cid/ciy212.Peer-Reviewed Original ResearchConceptsPolymerase chain reactionAsymptomatic infectionTick biteHuman babesiosisInfection 9 monthsRecent tick biteViral-like illnessCommon clinical manifestationsHaemaphysalis concinna ticksCase seriesInitial diagnosisClinical manifestationsOvarian tumorsModerate symptomsUS CentersBlood supplySevere diseaseHealthy residentsHealth problemsDisease controlInfectionChain reactionGenetic sequencingPatientsFurther investigation
2015
Apheresis for babesiosis: Therapeutic parasite reduction or removal of harmful toxins or both?
Saifee NH, Krause PJ, Wu Y. Apheresis for babesiosis: Therapeutic parasite reduction or removal of harmful toxins or both? Journal Of Clinical Apheresis 2015, 31: 454-458. PMID: 26481763, DOI: 10.1002/jca.21429.Peer-Reviewed Original ResearchConceptsExchange transfusionHigh-risk populationLife-threatening illnessApparent therapeutic benefitBlood transfusionModerate diseaseClinical presentationAsymptomatic infectionSevere babesiosisSevere diseaseRisk populationsTherapeutic benefitTransfusionMortality rateIntraerythrocytic protozoan parasiteBabesia infectionDiseaseIxodes ticksProtozoan parasiteBabesiosisInfectionGenus BabesiaMost casesPatientsClindamycinBorrelia miyamotoi infection in nature and in humans
Krause PJ, Fish D, Narasimhan S, Barbour AG. Borrelia miyamotoi infection in nature and in humans. Clinical Microbiology And Infection 2015, 21: 631-639. PMID: 25700888, PMCID: PMC4470780, DOI: 10.1016/j.cmi.2015.02.006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsB. miyamotoi infectionMiyamotoi infectionClinical manifestationsB. miyamotoiLyme diseaseBorrelia miyamotoi infectionAcute febrile illnessCommon clinical manifestationsBlood smear examinationPublic health importanceHuman granulocytic anaplasmosisFever group spirochetesFebrile illnessAntibiotic therapyDisease groupEtiologic diagnosisSevere diseaseSmear examinationIxodes persulcatus ticksHealth importanceInfectionHuman casesGranulocytic anaplasmosisBorrelia miyamotoiDisease
2009
Update on Babesiosis
Vannier E, Krause PJ. Update on Babesiosis. Interdisciplinary Perspectives On Infectious Diseases 2009, 2009: 984568. PMID: 19727410, PMCID: PMC2734943, DOI: 10.1155/2009/984568.Peer-Reviewed Original ResearchTick-borne infectious diseaseHuman babesiosisBlood safety riskSpecific antimicrobial therapyMultiple prevention strategiesFulminant diseaseThin blood smearsClinical featuresExchange transfusionModerate illnessImmunosuppressive drugsAsymptomatic infectionDefinitive diagnosisAsymptomatic carriersAntimicrobial therapyConvalescent seraSevere diseaseImmunocompromised individualsHigh riskSevere casesEndemic areasPrevention strategiesBabesia antibodiesHealthy adultsInfection range
2008
Human Babesiosis
Vannier E, Gewurz BE, Krause PJ. Human Babesiosis. Infectious Disease Clinics Of North America 2008, 22: 469-488. PMID: 18755385, PMCID: PMC3998201, DOI: 10.1016/j.idc.2008.03.010.Peer-Reviewed Original ResearchConceptsBabesial infectionHuman babesiosisCombination of atovaquoneTreatment of choiceSpecific laboratory diagnosisModerate illnessExchange transfusionPolymerase chain reactionSevere diseaseLaboratory diagnosisMorphologic examinationBlood smearsProtozoal parasitesInfectionChain reactionBabesial DNABabesiosisIntraerythrocytic infectionUnited StatesIxodid ticksTransfusionUpper midwestern regionsClindamycinSerologyAzithromycin
2003
Babesiosis Diagnosis and Treatment
Krause PJ. Babesiosis Diagnosis and Treatment. Vector-Borne And Zoonotic Diseases 2003, 3: 45-51. PMID: 12804380, DOI: 10.1089/153036603765627451.Peer-Reviewed Original ResearchConceptsBlood smearsThin blood smearsPolymerase chain reactionRobust antibody responseLife-saving therapyUseful screening testPulmonary compromiseSubclinical illnessSerologic testingClinical manifestationsExchange transfusionAntibody responseAdverse reactionsHigh parasitemiaConclusive diagnosisSevere diseaseAccurate diagnosisScreening testBabesial infectionBabesia microtiHuman babesiosisInfectionSignificant hemolysisDiseaseSmears
2000
Babesiosis
Krause P. Babesiosis. Seminars In Pediatric Infectious Diseases 2000, 11: 182-188. DOI: 10.1053/pi.2000.6229.Peer-Reviewed Original ResearchCombination of clindamycinHuman immunodeficiency virusTypical clinical symptomsPeripheral blood smearDefinitive laboratory diagnosisClinical symptomsImmunodeficiency virusAsymptomatic infectionClinical spectrumSerological evaluationCurrent treatmentSevere diseaseLaboratory diagnosisSporadic casesBlood smearsIntraerythrocytic protozoaLyme diseaseDiseaseEndemic diseaseZoonotic diseaseCausative agentSerious episodesIxodes ticksBabesiosisAdults