2023
Immune Control in Repeated Babesia microti Infection in a Patient With B-Cell Deficiency
Little J, Oakley M, Thorner A, Johnston D, Majam V, Liakos A, Novack L, Zheng H, Meredith S, Chou C, Newton B, Soiffer R, Krause P, Baden L, Kumar S. Immune Control in Repeated Babesia microti Infection in a Patient With B-Cell Deficiency. Open Forum Infectious Diseases 2023, 11: ofad568. PMID: 38213635, PMCID: PMC10783156, DOI: 10.1093/ofid/ofad568.Peer-Reviewed Original ResearchB-cell deficiencyParasite burdenHuman babesiosisBabesia microti infectionHigher antibody levelsMild clinical symptomsSevere B cell deficiencyB cell populationsT memory stem cellsMemory stem cellsPeak parasite burdenClinical immunityImmune controlImmunologic findingsNK cellsAntibody levelsClinical symptomsMicroti infectionB cellsPatientsSpecific antibodiesStem cellsBabesiosisImmunologyDeficiencyNeurologic Complications of Babesiosis, United States, 2011–2021 - Volume 29, Number 6—June 2023 - Emerging Infectious Diseases journal - CDC
Locke S, O’Bryan J, Zubair A, Rethana M, Moffarah A, Krause P, Farhadian S. Neurologic Complications of Babesiosis, United States, 2011–2021 - Volume 29, Number 6—June 2023 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2023, 29: 1127-1135. PMID: 37209667, PMCID: PMC10202888, DOI: 10.3201/eid2906.221890.Peer-Reviewed Original ResearchConceptsNeurologic complicationsNeurologic symptomsRisk factorsYale-New Haven HospitalInfectious Diseases journal - CDCHigh-grade parasitemiaNeurologic risk factorsRange of symptomsAdult patientsRenal failureDiabetes mellitusFrequent symptomsHospital admissionImpaired consciousnessMedical recordsEndemic areasParasitic infectionsPatientsSymptomsIntraerythrocytic protozoaComplicationsBabesiosisNew HavenDeliriumMellitus
2022
Animal models of the immunology and pathogenesis of human babesiosis
Kumar A, Kabra A, Igarashi I, Krause P. Animal models of the immunology and pathogenesis of human babesiosis. Trends In Parasitology 2022, 39: 38-52. PMID: 36470781, DOI: 10.1016/j.pt.2022.11.003.Peer-Reviewed Original ResearchConceptsAnimal modelsHuman babesiosisBabesia infectionImmunological mechanismsModerate diseaseOrgan dysfunctionPathologic responseDisease complicationsAsymptomatic infectionSevere diseaseAnimal studiesInfectionPathological processesDiseaseBabesiosisBabesia speciesAnimalsDomestic animalsComplicationsDysfunctionPathogenesisImmunologyEpidemiology of Hospitalized Patients with Babesiosis, United States, 2010–2016 - Volume 28, Number 2—February 2022 - Emerging Infectious Diseases journal - CDC
Bloch EM, Day JR, Krause PJ, Kjemtrup A, O’Brien S, Tobian AAR, Goel R. Epidemiology of Hospitalized Patients with Babesiosis, United States, 2010–2016 - Volume 28, Number 2—February 2022 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2022, 28: 354-362. PMID: 35076004, PMCID: PMC8798708, DOI: 10.3201/eid2802.210213.Peer-Reviewed Original ResearchConceptsNational Inpatient Sample databaseInfectious Diseases journal - CDCAnalysis of hospitalizationsHospitalized patientsAdvanced ageMortality rateHospitalizationSample databaseObservation periodEpidemiologyHigher severityPatientsBabesiosisDiagnosisUnited StatesReporting dataBabesiaAdmissionIllnessIncidenceDiseaseSeverity
2021
The Global Emergence of Human Babesiosis
Kumar A, O’Bryan J, Krause PJ. The Global Emergence of Human Babesiosis. Pathogens 2021, 10: 1447. PMID: 34832603, PMCID: PMC8623124, DOI: 10.3390/pathogens10111447.Peer-Reviewed Original ResearchHuman babesiosisPrimary clinical characteristicsEndemic diseaseGlobal health burdenHard-bodied ticksMode of transmissionFulminant casesTick-borne diseaseClinical characteristicsBlood transfusionDisease locationHealth burdenOrgan transplantationEpidemiologic toolIntraerythrocytic protozoaDiseaseBabesiosisInfectionLike agentsGlobal emergenceHuman pathogensUnited StatesBabesiaWide spectrumPredominant speciesBabesiosis
Chen T, Mamoun C, Krause P. Babesiosis. 2021, 1298-1304. DOI: 10.1093/med/9780190888367.003.0200.Peer-Reviewed Original ResearchB. microtiHard-bodied ticksHuman granulocytic anaplasmosisPowassan virusEtiologic agentIntraerythrocytic protozoaLyme diseaseBorrelia miyamotoiGranulocytic anaplasmosisBabesia infectionBorrelia burgdorferiDiseaseZoonotic diseaseB. duncaniAnaplasma phagocytophilumApicomplexa phylumInfectionMicrotiB. venatorumB. divergensBabesia sppBabesiosisIxodes scapularisPrimary vectorFeverRecurrence of Human Babesiosis Caused by Reinfection - Volume 27, Number 10—October 2021 - Emerging Infectious Diseases journal - CDC
Ho J, Carey E, Carey DE, Krause PJ. Recurrence of Human Babesiosis Caused by Reinfection - Volume 27, Number 10—October 2021 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2021, 27: 2659-2661. PMID: 34546166, PMCID: PMC8462340, DOI: 10.3201/eid2710.211240.Peer-Reviewed Original ResearchPreventing Transfusion-Transmitted Babesiosis
Bloch EM, Krause PJ, Tonnetti L. Preventing Transfusion-Transmitted Babesiosis. Pathogens 2021, 10: 1176. PMID: 34578209, PMCID: PMC8468711, DOI: 10.3390/pathogens10091176.Peer-Reviewed Original ResearchTransfusion-transmitted babesiosisBlood donor testingHealthy blood donorsIntra-erythrocytic parasitesDonor surveillanceTransfusion transmissibleDonor testingHigh morbidityTransfusion recipientsSevere babesiosisBlood donorsBlood supplyBlood safetyHigh riskGlobal epidemiologyHuman babesiosisCausative agentMolecular assaysUnited StatesBabesiosisInfectionRiskMajor riskImmunopathogenesisMorbidityBabesia microti: Pathogen Genomics, Genetic Variability, Immunodominant Antigens, and Pathogenesis
Puri A, Bajpai S, Meredith S, Aravind L, Krause PJ, Kumar S. Babesia microti: Pathogen Genomics, Genetic Variability, Immunodominant Antigens, and Pathogenesis. Frontiers In Microbiology 2021, 12: 697669. PMID: 34539601, PMCID: PMC8446681, DOI: 10.3389/fmicb.2021.697669.Peer-Reviewed Original ResearchPolymerase chain reactionPerinatal transmissionBlood transfusionModerate diseaseMost infectionsOrgan transplantationImmune evasionBlood smearsImmunodominant antigensHuman babesiosisInfection severityPathogenesisChain reactionPotential roleCell surface proteinsDiseaseDiagnosisHuman diseasesPathogen genomicsBabesiosisIxodid ticksPhylum ApicomplexaTransfusionTransplantationHumansClinical Practice Guidelines by the Infectious Diseases Society of America (IDSA): 2020 Guideline on Diagnosis and Management of Babesiosis
Krause PJ, Auwaerter PG, Bannuru RR, Branda JA, Falck-Ytter YT, Lantos PM, Lavergne V, Meissner HC, Osani MC, Rips JG, Sood SK, Vannier E, Vaysbrot EE, Wormser GP. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA): 2020 Guideline on Diagnosis and Management of Babesiosis. Clinical Infectious Diseases 2021, 72: 185-189. PMID: 33501959, DOI: 10.1093/cid/ciab050.Peer-Reviewed Original ResearchConceptsInfectious Diseases SocietyDiseases SocietyInfectious disease specialistsClinical practice guidelinesPrimary care physiciansTransfusion medicine specialistsEvidence-based guidanceHuman granulocytic anaplasmosisRheumatology guidelinesDisease guidelinesCare physiciansDisease specialistsEmergency physiciansPractice guidelinesAmerican CollegeMedicine specialistsAmerican AcademyDisease controlLyme diseaseGranulocytic anaplasmosisDiagnosisPhysiciansBabesiosisGuidelinesTreatment
2020
Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA): 2020 Guideline on Diagnosis and Management of Babesiosis
Krause PJ, Auwaerter PG, Bannuru RR, Branda JA, Falck-Ytter YT, Lantos PM, Lavergne V, Meissner HC, Osani MC, Rips JG, Sood SK, Vannier E, Vaysbrot EE, Wormser GP. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA): 2020 Guideline on Diagnosis and Management of Babesiosis. Clinical Infectious Diseases 2020, 72: e49-e64. PMID: 33252652, DOI: 10.1093/cid/ciaa1216.Peer-Reviewed Original ResearchConceptsInfectious Diseases SocietyDiseases SocietyInfectious disease specialistsClinical practice guidelinesPrimary care physiciansTransfusion medicine specialistsEvidence-based guidanceHuman granulocytic anaplasmosisRheumatology guidelinesDisease guidelinesCare physiciansDisease specialistsEmergency physiciansPractice guidelinesAmerican CollegeMedicine specialistsAmerican AcademyDisease controlLyme diseaseGranulocytic anaplasmosisDiagnosisPhysiciansBabesiosisGuidelinesTreatment105 Babesiosis
Vannier E, Krause P. 105 Babesiosis. 2020, 799-802. DOI: 10.1016/b978-0-323-55512-8.00105-8.Peer-Reviewed Original ResearchPolymerase chain reactionProphylactic antibiotic regimenLife-threatening complicationsMainstay of treatmentSolid organ transplantationBest preventive measureAntibiotic regimenFrequent symptomsHospital admissionDefinitive diagnosisSevere babesiosisBlood productsOrgan transplantationEtiologic agentBabesia microtiPreventive measuresZoonotic diseaseChain reactionB. duncaniBabesiosisDiseaseB. venatorumHemoprotozoan parasitesB. divergensAlternative option
2019
Repeat exchange transfusion for treatment of severe babesiosis
Radcliffe C, Krause PJ, Grant M. Repeat exchange transfusion for treatment of severe babesiosis. Transfusion And Apheresis Science 2019, 58: 638-640. PMID: 31526674, DOI: 10.1016/j.transci.2019.07.010.Peer-Reviewed Case Reports and Technical NotesConceptsRepeat exchange transfusionExchange transfusionSevere babesiosisHospital day 5Second exchange transfusionBabesia microti infectionHigh feverRheumatoid arthritisMicroti infectionTransfusionDay 5Literature searchDearth of informationParasitemiaInfectionBabesiosisEtanerceptArthritisFeverClindamycinHypoxiaCasesWeeksWomenHuman babesiosis
Krause PJ. Human babesiosis. International Journal For Parasitology 2019, 49: 165-174. PMID: 30690090, DOI: 10.1016/j.ijpara.2018.11.007.Peer-Reviewed Original ResearchConceptsBurden of infectionSignificant health burdenNon-endemic areasTick-borne diseaseThin blood smearsBlood transfusionExchange transfusionHealth burdenSevere casesBlood smearsHuman babesiosisIntraerythrocytic parasitesTransfusionInfectionBabesiosisBurdenProtective measuresBabesia DNAClindamycinAzithromycinAtovaquoneDiseaseSmearsDiagnosis
2016
Transfusion-transmitted babesiosis
Levin AE, Krause PJ. Transfusion-transmitted babesiosis. Current Opinion In Hematology 2016, 23: 573-580. PMID: 27537475, PMCID: PMC5241272, DOI: 10.1097/moh.0000000000000287.Peer-Reviewed Original ResearchConceptsTransfusion-transmitted babesiosisBlood donorsB. microti antibodiesInfectious blood donorsAssociated mortality rateOptimal screening strategyTransfusion-transmitted pathogensSignificant health burdenAvailable screening toolsUnited States populationPathogen inactivation methodsMicroti antibodiesSevere illnessHealth burdenMortality rateUS FoodDrug AdministrationBabesia microtiScreening toolLaboratory screeningScreening strategyBabesiosisInactivation methodPCR assaysRecent studies
2015
Apheresis for babesiosis: Therapeutic parasite reduction or removal of harmful toxins or both?
Saifee NH, Krause PJ, Wu Y. Apheresis for babesiosis: Therapeutic parasite reduction or removal of harmful toxins or both? Journal Of Clinical Apheresis 2015, 31: 454-458. PMID: 26481763, DOI: 10.1002/jca.21429.Peer-Reviewed Original ResearchConceptsExchange transfusionHigh-risk populationLife-threatening illnessApparent therapeutic benefitBlood transfusionModerate diseaseClinical presentationAsymptomatic infectionSevere babesiosisSevere diseaseRisk populationsTherapeutic benefitTransfusionMortality rateIntraerythrocytic protozoan parasiteBabesia infectionDiseaseIxodes ticksProtozoan parasiteBabesiosisInfectionGenus BabesiaMost casesPatientsClindamycinBabesiosis
Vannier EG, Diuk-Wasser MA, Mamoun C, Krause PJ. Babesiosis. Infectious Disease Clinics Of North America 2015, 29: 357-370. PMID: 25999229, PMCID: PMC4458703, DOI: 10.1016/j.idc.2015.02.008.Peer-Reviewed Original Research
2014
Monitoring Human Babesiosis Emergence through Vector Surveillance New England, USA - Volume 20, Number 2—February 2014 - Emerging Infectious Diseases journal - CDC
Diuk-Wasser MA, Liu Y, Steeves TK, Folsom-O'Keefe C, Dardick KR, Lepore T, Bent SJ, Usmani-Brown S, Telford SR, Fish D, Krause PJ. Monitoring Human Babesiosis Emergence through Vector Surveillance New England, USA - Volume 20, Number 2—February 2014 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2014, 20: 225-231. PMID: 24447577, PMCID: PMC3901474, DOI: 10.3201/eid2002.130644.Peer-Reviewed Original ResearchConceptsHuman babesiosisInfectious Diseases journal - CDCProtozoan Babesia microtiDisease-endemic areasTick-borne diseaseBabesiosis-endemic areasSame tick vectorInfection rateInfection ratioTick infection ratesLyme diseaseBabesia microtiHuman casesDiseaseDisease expansionBabesiosisReservoir hostsTick vectorHuman diseasesSurveillanceClose association
2013
Chapter 14 Neurological manifestations of human babesiosis
Usmani-Brown S, Halperin JJ, Krause PJ. Chapter 14 Neurological manifestations of human babesiosis. Handbook Of Clinical Neurology 2013, 114: 199-203. PMID: 23829910, DOI: 10.1016/b978-0-444-53490-3.00014-5.Peer-Reviewed Original ResearchConceptsLevel of consciousnessRare complicationBlood transfusionNeurological manifestationsCommon symptomsNeurological dysfunctionFatal diseaseInfectious diseasesIntraerythrocytic protozoaHuman babesiosisDiseaseBabesiosisIxodid ticksTransfusionComplicationsHeadacheDysfunctionLethargyPathogenesisSymptoms
2010
Emergence of Resistance to Azithromycin-Atovaquone in Immunocompromised Patients with Babesia microti Infection
Wormser GP, Prasad A, Neuhaus E, Joshi S, Nowakowski J, Nelson J, Mittleman A, Aguero-Rosenfeld M, Topal J, Krause PJ. Emergence of Resistance to Azithromycin-Atovaquone in Immunocompromised Patients with Babesia microti Infection. Clinical Infectious Diseases 2010, 50: 381-386. PMID: 20047477, DOI: 10.1086/649859.Peer-Reviewed Original ResearchConceptsDrug regimenB. microtiLevel of immunosuppressionBabesia microti infectionTreatment of babesiosisDrug-resistant strainsEmergence of resistanceActive babesiosisMicrobiologic relapseLaboratory abnormalitiesDrug regimensImmunocompromised patientsOptimal therapyTreatment failureDrug therapyMicroti infectionPatientsClinical case historiesDrug resistanceBabesia microtiInfectionRegimenMicrotiEventual developmentBabesiosis