2023
Immune Control in Repeated Babesia microti Infection in a Patient With B-Cell Deficiency
Little J, Oakley M, Thorner A, Johnston D, Majam V, Liakos A, Novack L, Zheng H, Meredith S, Chou C, Newton B, Soiffer R, Krause P, Baden L, Kumar S. Immune Control in Repeated Babesia microti Infection in a Patient With B-Cell Deficiency. Open Forum Infectious Diseases 2023, 11: ofad568. PMID: 38213635, PMCID: PMC10783156, DOI: 10.1093/ofid/ofad568.Peer-Reviewed Original ResearchB-cell deficiencyParasite burdenHuman babesiosisBabesia microti infectionHigher antibody levelsMild clinical symptomsSevere B cell deficiencyB cell populationsT memory stem cellsMemory stem cellsPeak parasite burdenClinical immunityImmune controlImmunologic findingsNK cellsAntibody levelsClinical symptomsMicroti infectionB cellsPatientsSpecific antibodiesStem cellsBabesiosisImmunologyDeficiencyThe impact of ABO and RhD blood types on Babesia microti infection
Jajosky R, O’Bryan J, Spichler-Moffarah A, Jajosky P, Krause P, Tonnetti L. The impact of ABO and RhD blood types on Babesia microti infection. PLOS Neglected Tropical Diseases 2023, 17: e0011060. PMID: 36696414, PMCID: PMC9901808, DOI: 10.1371/journal.pntd.0011060.Peer-Reviewed Original ResearchConceptsB. microti infectionABO blood typeBabesia microti infectionMicroti infectionBlood donorsBlood typeDisease severityPlasmodium falciparum malaria patientsFalciparum malaria patientsHigher peak parasitemiaRed blood cell antigensType BImpact of ABOBlood cell antigensBlood type BMalaria patientsTransfusion strategyInfected donorsRhD blood typeSevere diseasePeak parasitemiaB antigensCell antigensPossible associationRhD antigen
2022
Frequency and Geographic Distribution of Borrelia miyamotoi, Borrelia burgdorferi, and Babesia microti Infections in New England Residents.
Johnston D, Kelly JR, Ledizet M, Lavoie N, Smith RP, Parsonnet J, Schwab J, Stratidis J, Espich S, Lee G, Maciejewski KR, Deng Y, Majam V, Zheng H, Bonkoungou SN, Stevens J, Kumar S, Krause PJ. Frequency and Geographic Distribution of Borrelia miyamotoi, Borrelia burgdorferi, and Babesia microti Infections in New England Residents. Clinical Infectious Diseases 2022 PMID: 35325084, DOI: 10.1093/cid/ciac107.Peer-Reviewed Original ResearchBabesia microti infectionB. miyamotoiMicroti infectionB. burgdorferiB. microtiAcute undifferentiated febrile illnessCross-sectional seroprevalence studyBorrelia miyamotoiUndifferentiated febrile illnessB. miyamotoi infectionBorrelia burgdorferiLevel of seroprevalenceIxodes scapularis ticksFebrile illnessTickborne infectionMiyamotoi infectionSeroprevalence studyHuman infectionsIxodes pacificus ticksClinical casesInfectionSerum samplesAverage seroprevalenceSpecific antibodiesScapularis ticks
2020
Parasite burden and red blood cell exchange transfusion for babesiosis
O'Bryan J, Gokhale A, Hendrickson JE, Krause PJ. Parasite burden and red blood cell exchange transfusion for babesiosis. Journal Of Clinical Apheresis 2020, 36: 127-134. PMID: 33179803, PMCID: PMC9517950, DOI: 10.1002/jca.21853.Peer-Reviewed Original ResearchConceptsEnd-organ dysfunctionPeak parasitemia levelsRed blood cell exchange transfusionParasitemia levelsExchange transfusionPeak parasitemiaDisease severityParasite burdenYale-New Haven HospitalBabesia microti parasitemiaHigh-grade parasitemiaRetrospective chart reviewBabesia microti infectionNew Haven HospitalAntimicrobial agentsChart reviewHepatic dysfunctionPatient demographicsClinical statusMedian lengthLaboratory indicatorsMicroti infectionDegree of hemolysisNineteen subjectsDysfunctionClofazimine, a Promising Drug for the Treatment of Babesia microti Infection in Severely Immunocompromised Hosts
Tuvshintulga B, Vannier E, Tayebwa DS, Gantuya S, Sivakumar T, Guswanto A, Krause PJ, Yokoyama N, Igarashi I. Clofazimine, a Promising Drug for the Treatment of Babesia microti Infection in Severely Immunocompromised Hosts. The Journal Of Infectious Diseases 2020, 222: 1027-1036. PMID: 32310272, DOI: 10.1093/infdis/jiaa195.Peer-Reviewed Original ResearchConceptsB. microti parasitesMicroti infectionHigh-grade parasitemiaDrug-resistant tuberculosisB. microtiBabesia microti infectionAdditional preclinical studiesB. microti infectionImmunocompromised hostB. microti DNAPolymerase chain reactionPreclinical studiesIncidence of babesiosisPromising drugRadical cureMinimal doseClofazimineDay 10Blood smearsBabesia microtiNovel drugsParasitemiaChain reactionMicroscopic examinationAntimicrobial agents
2019
Repeat exchange transfusion for treatment of severe babesiosis
Radcliffe C, Krause PJ, Grant M. Repeat exchange transfusion for treatment of severe babesiosis. Transfusion And Apheresis Science 2019, 58: 638-640. PMID: 31526674, DOI: 10.1016/j.transci.2019.07.010.Peer-Reviewed Case Reports and Technical NotesConceptsRepeat exchange transfusionExchange transfusionSevere babesiosisHospital day 5Second exchange transfusionBabesia microti infectionHigh feverRheumatoid arthritisMicroti infectionTransfusionDay 5Literature searchDearth of informationParasitemiaInfectionBabesiosisEtanerceptArthritisFeverClindamycinHypoxiaCasesWeeksWomenPersistence of Babesia microti Infection in Humans
Bloch EM, Kumar S, Krause PJ. Persistence of Babesia microti Infection in Humans. Pathogens 2019, 8: 102. PMID: 31319461, PMCID: PMC6789900, DOI: 10.3390/pathogens8030102.Peer-Reviewed Original ResearchTransfusion-transmitted babesiosisBabesia microti infectionBlood donor screeningImmune evasive strategiesPeripheral blood smearFifth of casesHost immune mechanismsNovel therapeutic measuresNovel preventive approachesHIV/AIDSTick-borne diseaseRed blood cellsSevere complicationsAnti-parasitic drugsBlood transfusionImmunocompetent individualsImmunosuppressive drugsDonor screeningMicroti infectionImmune mechanismsBlood donorsHealth burdenImmunoglobulin preparationsNew anti-parasitic drugsTherapeutic measures
2018
BmGPAC, an Antigen Capture Assay for Detection of Active Babesia microti Infection
Thekkiniath J, Mootien S, Lawres L, Perrin BA, Gewirtz M, Krause PJ, Williams S, Doggett J, Ledizet M, Mamoun C. BmGPAC, an Antigen Capture Assay for Detection of Active Babesia microti Infection. Journal Of Clinical Microbiology 2018, 56: 10.1128/jcm.00067-18. PMID: 30093394, PMCID: PMC6156295, DOI: 10.1128/jcm.00067-18.Peer-Reviewed Original ResearchConceptsHuman babesiosisBabesia microti infectionCapture enzyme-linked immunosorbent assayAntigen capture enzyme-linked immunosorbent assayAntigen capture assayEnzyme-linked immunosorbent assayZoonotic infectious diseaseAcute infectionBlood transfusionAsymptomatic infectionMicroti infectionReal-time PCRBlood supplyAnimal reservoir hostsDonor bloodEpidemiological surveyHuman patientsImmune systemSerological assaysImmunodominant antigensInfectionInfectious diseasesIntraerythrocytic protozoan parasitePatientsImmunosorbent assay
2010
Emergence of Resistance to Azithromycin-Atovaquone in Immunocompromised Patients with Babesia microti Infection
Wormser GP, Prasad A, Neuhaus E, Joshi S, Nowakowski J, Nelson J, Mittleman A, Aguero-Rosenfeld M, Topal J, Krause PJ. Emergence of Resistance to Azithromycin-Atovaquone in Immunocompromised Patients with Babesia microti Infection. Clinical Infectious Diseases 2010, 50: 381-386. PMID: 20047477, DOI: 10.1086/649859.Peer-Reviewed Original ResearchConceptsDrug regimenB. microtiLevel of immunosuppressionBabesia microti infectionTreatment of babesiosisDrug-resistant strainsEmergence of resistanceActive babesiosisMicrobiologic relapseLaboratory abnormalitiesDrug regimensImmunocompromised patientsOptimal therapyTreatment failureDrug therapyMicroti infectionPatientsClinical case historiesDrug resistanceBabesia microtiInfectionRegimenMicrotiEventual developmentBabesiosis
2008
Persistent and Relapsing Babesiosis in Immunocompromised Patients
Krause PJ, Gewurz BE, Hill D, Marty FM, Vannier E, Foppa IM, Furman RR, Neuhaus E, Skowron G, Gupta S, McCalla C, Pesanti EL, Young M, Heiman D, Hsue G, Gelfand JA, Wormser GP, Dickason J, Bia FJ, Hartman B, Telford SR, Christianson D, Dardick K, Coleman M, Girotto JE, Spielman A. Persistent and Relapsing Babesiosis in Immunocompromised Patients. Clinical Infectious Diseases 2008, 46: 370-376. PMID: 18181735, DOI: 10.1086/525852.Peer-Reviewed Original ResearchConceptsCase patientsAntibabesial treatmentClinical courseControl subjectsBlood smearsRetrospective case-control studyOptimal treatment regimenStandard antimicrobial therapyMalaria-like illnessBabesia microti infectionMost cases patientsCase-control studyCourse of therapyB-cell lymphomaAdministration of atovaquoneImmunologic statusStandard therapyAntimicrobial regimenSuch patientsTreatment regimenMicroti infectionAntimicrobial therapyPersistent infectionCell lymphomaAcute babesiosis
2007
ATOVAQUONE AND AZITHROMYCIN TREATMENT FOR BABESIOSIS IN AN INFANT
Raju M, Salazar JC, Leopold H, Krause PJ. ATOVAQUONE AND AZITHROMYCIN TREATMENT FOR BABESIOSIS IN AN INFANT. The Pediatric Infectious Disease Journal 2007, 26: 181-183. PMID: 17259886, DOI: 10.1097/01.inf.0000250622.11505.8f.Peer-Reviewed Original ResearchConceptsCyanotic heart diseaseBabesia microti infectionTreatment of childrenOral azithromycinThin blood smearsInitial presentationSevere anemiaHeart diseaseMicroti infectionPolymerase chain reactionHepatic enzymesBlood smearsInfantsIntraerythrocytic parasitesChain reactionTreatmentBabesiosisLaboratory testsFebrileThrombocytopeniaCyanoticAnemiaClindamycinSerologyAzithromycin
2006
Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient
Clark IA, Budd AC, Hsue G, Haymore BR, Joyce AJ, Thorner R, Krause PJ. Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient. Malaria Journal 2006, 5: 69. PMID: 16887045, PMCID: PMC1552079, DOI: 10.1186/1475-2875-5-69.Peer-Reviewed Original ResearchConceptsMulti-organ failureParasitized erythrocytesSevere multi-organ failureBabesia microti infectionChronic lymphocytic leukemiaCases of babesiosisFalciparum malariaSplenectomized patientsSimilar pathogenesisVascular occlusionMicroti infectionErythrocyte sequestrationLymphocytic leukemiaProtozoal infectionsVascular locationColon cancerHuman patientsResultsNo evidenceVascular lumenHuman casesB. microtiTissue sectionsPatientsPathogenesisInfection
1999
Southern Extension of the Range of Human Babesiosis in the Eastern United States
Eskow E, Krause P, Spielman A, Freeman K, Aslanzadeh J. Southern Extension of the Range of Human Babesiosis in the Eastern United States. Journal Of Clinical Microbiology 1999, 37: 2051-2052. PMID: 10325378, PMCID: PMC85028, DOI: 10.1128/jcm.37.6.2051-2052.1999.Peer-Reviewed Original ResearchConceptsMicroti infectionBlood samplesB. microti antibodiesSerial blood samplesBabesia microti infectionB. microti infectionCollected blood samplesMicroti antibodiesAcute babesiosisImmunofluorescent antibodyHuman B. microti infectionBabesial antigensHuman babesiosisB. microtiInfectionBabesiosisAntibodiesPCR techniqueUnited StatesLocal acquisitionResidentsPatientsSymptomsAntigenBlood