2024
Gene expression meta-analysis reveals aging and cellular senescence signatures in scleroderma-associated interstitial lung disease
Yang M, Lee S, Neely J, Hinchcliff M, Wolters P, Sirota M. Gene expression meta-analysis reveals aging and cellular senescence signatures in scleroderma-associated interstitial lung disease. Frontiers In Immunology 2024, 15: 1326922. PMID: 38348044, PMCID: PMC10859856, DOI: 10.3389/fimmu.2024.1326922.Peer-Reviewed Original ResearchConceptsScleroderma-associated interstitial lung diseaseSSc-ILDInterstitial lung diseaseLung tissueGene expression meta-analysisPulmonary fibrosisLung diseaseSenescence signatureDegree of skin involvementIdiopathic pulmonary fibrosisTelomere lengthType II alveolar cellsCellular senescence signaturesCellular senescenceIndependent of ageSkin involvementSSc skinExpression meta-analysisHealthy controlsAssociated with degreeAlveolar cellsLungMeta-analysisAging genesFibrosis
2016
The association between systemic sclerosis disease manifestations and esophageal high‐resolution manometry parameters
Kimmel JN, Carlson DA, Hinchcliff M, Carns MA, Aren KA, Lee J, Pandolfino JE. The association between systemic sclerosis disease manifestations and esophageal high‐resolution manometry parameters. Neurogastroenterology & Motility 2016, 28: 1157-1165. PMID: 26921101, PMCID: PMC4956560, DOI: 10.1111/nmo.12813.Peer-Reviewed Original ResearchConceptsHigh-resolution manometrySSc disease durationClinical characteristicsMotility diagnosisNormal motilityHigh-resolution manometry parametersSevere esophageal dysfunctionWorse lung functionIneffective esophageal motilityPulmonary function testsRetrospective chart reviewRodnan skin scoreSkin disease severitySymptoms of dysphagiaAbsent contractilityEsophageal dysfunctionChart reviewSkin involvementSSc patientsLung functionSkin scoreSystemic manifestationsSystemic sclerosisEsophageal contractilityEsophageal motility