Featured Publications
Evidence of leaky protection following COVID-19 vaccination and SARS-CoV-2 infection in an incarcerated population
Lind M, Dorion M, Houde A, Lansing M, Lapidus S, Thomas R, Yildirim I, Omer S, Schulz W, Andrews J, Hitchings M, Kennedy B, Richeson R, Cummings D, Ko A. Evidence of leaky protection following COVID-19 vaccination and SARS-CoV-2 infection in an incarcerated population. Nature Communications 2023, 14: 5055. PMID: 37598213, PMCID: PMC10439918, DOI: 10.1038/s41467-023-40750-8.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionPrior infectionHybrid immunityInfection riskCOVID-19 vaccinationNon-pharmaceutical interventionsInfected residentsVaccinationInfectionDocumented exposureDelta periodCell exposureIncarcerated populationsExposureImmunityRiskAssociationPotential benefitsCorrectional facilitiesCrowded settingsResidentsPeriodCOVID-19 Vaccine Acceptance and Hesitancy Among Health Care Workers in Lebanon
Youssef N, Tfaily N, Moumneh M, Boutros C, Elharake J, Malik A, McFadden S, Galal B, Yildirim I, Khoshnood K, Omer S, Memish Z, Dbaibo G. COVID-19 Vaccine Acceptance and Hesitancy Among Health Care Workers in Lebanon. Journal Of Epidemiology And Global Health 2023, 13: 55-66. PMID: 36735184, PMCID: PMC9896451, DOI: 10.1007/s44197-023-00086-4.Peer-Reviewed Original ResearchConceptsHealth care workersCOVID-19 vaccine acceptanceVaccine acceptancePrevious infectionCare workersPrevious SARS-CoV-2 infectionSARS-CoV-2 infectionMethodsA cross-sectional studyCOVID-19 vaccination ratesCOVID-19 vaccinationCross-sectional studyCOVID-19 vaccineHealth care authoritiesVaccine uptakeVaccination ratesOrder of PhysiciansVaccine hesitancyGeneral populationHealthcare providersVaccineCare authoritiesInfectionCOVID-19 informationTrusted sourceCOVID-19 pandemic
2021
Risk of Disseminated Gonococcal Infections With Terminal Complement Blockade
Graciaa SH, Graciaa DS, Yildirim I, Chonat S. Risk of Disseminated Gonococcal Infections With Terminal Complement Blockade. Journal Of Pediatric Hematology/Oncology 2021, 44: e493-e495. PMID: 33560079, PMCID: PMC8556643, DOI: 10.1097/mph.0000000000002075.Peer-Reviewed Original ResearchConceptsTerminal complement blockadeComplement blockadeGonococcal infectionClonal hematopoietic stem cell disordersDisseminated gonococcal infectionHematopoietic stem cell disordersQuality of lifeStem cell disordersParoxysmal nocturnal hemoglobinuriaComplement protein C5Complement-mediated hemolysisProphylactic antibioticsIntravascular hemolysisAppropriate immunizationsAzithromycin resistanceCell disordersNocturnal hemoglobinuriaNeisseria gonorrhoeaeProtein C5Infection riskPatientsMonoclonal antibodiesNeisseria meningitidisBlockadeInfection
2020
Pulmonary Infections in the Immunocompromised Host
Yildirim I, Gibson J, Danziger-Isakov L. Pulmonary Infections in the Immunocompromised Host. Respiratory Medicine 2020, 235-252. DOI: 10.1007/978-3-030-54924-4_20.Peer-Reviewed Original ResearchPulmonary infectionHematopoietic stem cell transplantationCurrent immune statusSolid organ transplantationStem cell transplantationPrimary immunodeficiency patientsImmunocompromised childrenCommon complicationImmune compromiseImmunocompromised hostPulmonary diseaseBronchoalveolar lavageImaging findingsClinical symptomsCell transplantationImmune statusImmunodeficiency patientsInvasive studiesOrgan transplantationHigh riskCommon pathogensPatientsInfectionExposure historyTransplantation
2019
Cryptosporidiosis among solid organ transplant recipient attendees at a summer camp
McAteer J, Jernigan S, Mao C, Gonzalez MD, Watson RJ, Liverman R, Angelo M, M. H, Shane A, Yildirim I. Cryptosporidiosis among solid organ transplant recipient attendees at a summer camp. Pediatric Transplantation 2019, 24: e13649. PMID: 31885132, DOI: 10.1111/petr.13649.Peer-Reviewed Original ResearchConceptsTransplant recipientsSolid organ transplant recipientsKidney transplant recipientsRetrospective cohort studyOrgan transplant recipientsPediatric transplant recipientsOverall attack rateAcute rejection eventsLong-term interventionsImmunosuppressive therapySymptom durationCohort studyRisk factorsNotable burdenStool specimensCryptosporidiosis infectionEtiologic agentRejection eventsAttack rateFurther outbreaksInfectionRecipientsCryptosporidium hominisCryptosporidiosisOutbreak
2018
Assessment and Validation of Syndromic Case definitions for Respiratory Syncytial Virus Testing in a Low Resource Population
Omer SB, Bednarczyk R, Kazi M, Guterman LB, Aziz F, Allen KE, Yildirim I, Ali SA. Assessment and Validation of Syndromic Case definitions for Respiratory Syncytial Virus Testing in a Low Resource Population. The Pediatric Infectious Disease Journal 2018, Publish Ahead of Print: &na;. PMID: 30074977, PMCID: PMC6437080, DOI: 10.1097/inf.0000000000002159.Peer-Reviewed Original ResearchConceptsCommunity-based surveillanceCase definitionRespiratory syncytial virus testingRespiratory syncytial virus infectionSyncytial virus infectionLow-resource populationsStandardized case definitionsSyndromic case definitionsResource-limited settingsVaccine evaluationVirus infectionVirus testingYoung infantsVirus control strategiesModest specificitySurveillanceCyanosisWheezeApneaInfantsInfection
2010
A Case Report of Thrombocytopenia‐associated Multiple Organ Failure Secondary to Salmonella enterica Serotype Typhi Infection in a Pediatric Patient: Successful Treatment With Plasma Exchange
Yildirim I, Ceyhan M, Bayrakci B, Uysal M, Kuskonmaz B, Ozaltin F. A Case Report of Thrombocytopenia‐associated Multiple Organ Failure Secondary to Salmonella enterica Serotype Typhi Infection in a Pediatric Patient: Successful Treatment With Plasma Exchange. Therapeutic Apheresis And Dialysis 2010, 14: 226-229. PMID: 20438547, DOI: 10.1111/j.1744-9987.2009.00714.x.Peer-Reviewed Original ResearchConceptsSalmonella enterica serotype Typhi infectionMultiple organ failureS. typhi infectionTyphi infectionOrgan failurePlasma exchangeAggressive antimicrobial therapyPlasma exchange therapyLife-saving interventionsConventional supportive measuresSevere sepsisExchange therapyPediatric patientsCase reportAntimicrobial therapySuccessful treatmentSupportive measuresMortality rateAntimicrobial treatmentPatientsThrombocytopeniaInfectionTherapyHigher proportionTreatmentSerosurveillance study on transmission of H5N1 virus during a 2006 avian influenza epidemic
CEYHAN M, YILDIRIM I, FERRARIS O, BOUSCAMBERT-DUCHAMP M, FROBERT E, UYAR N, TEZER H, ONER AF, BUZGAN T, TORUNOGLU MA, OZKAN B, YILMAZ R, KURTOGLU MG, LALELI Y, BADUR S, LINA B. Serosurveillance study on transmission of H5N1 virus during a 2006 avian influenza epidemic. Epidemiology And Infection 2010, 138: 1274-1280. PMID: 20092669, DOI: 10.1017/s095026880999166x.Peer-Reviewed Original ResearchConceptsSerum samplesSubclinical infectionAvian influenza patientsSingle serum sampleAvian influenzaEnzyme-linked immunoassayPoultry cullersInfluenza patientsMicroneutralization assaysNasopharyngeal swabsPolymerase chain reactionSerosurveillance studiesH5N1 infectionHealthcare workersHaemagglutination inhibitionInfluenza epidemicsHuman infectionsSerological surveyFamily contactsHuman casesH5N1 virusInfectionDiseased poultryInfected chickensChain reactionRisks and outcome of fungal infection in neutropenic children with hematologic diseases.
Aytaç S, Yildirim I, Ceyhan M, Cetin M, Tuncer M, Kara A, Cengiz AB, Seçmeer G, Yetgin S. Risks and outcome of fungal infection in neutropenic children with hematologic diseases. The Turkish Journal Of Pediatrics 2010, 52: 121-5. PMID: 20560245.Peer-Reviewed Original ResearchConceptsFebrile neutropenic episodesAcute myeloid leukemiaNeutropenic episodesAcute lymphoblastic leukemiaAplastic anemiaAntifungal treatmentFungal infectionsMortality rateAmphotericin BNeutropenic childrenRetrospective studyLymphoblastic leukemiaMyeloid leukemiaHematologic diseasesTreatment groupsPatientsWhole groupInfectionEpisodesLeukemiaMortalityAnemiaGroupDiseaseFluconazole
2008
Cytomegalovirus hepatitis and ganciclovir treatment in immunocompetent children.
Tezer H, Seçmeer G, Kara A, Ceyhan M, Cengiz AB, Devrim I, Us D, Yüce A, Gürakan F, Yildirim I, Ozen H, Saltik-Temizel IN. Cytomegalovirus hepatitis and ganciclovir treatment in immunocompetent children. The Turkish Journal Of Pediatrics 2008, 50: 228-34. PMID: 18773667.Peer-Reviewed Original ResearchConceptsBiliary atresiaGanciclovir treatmentCauses of hepatitisCongenital CMV infectionExtrahepatic biliary atresiaSigns of infectionCMV hepatitisCholestatic hepatitisCMV infectionCytomegalovirus infectionImmunocompetent childrenStudy groupHepatitisPatientsGroup IIDemographic featuresGroup IInborn errorsInfectionAtresiaChildrenTreatmentGroupGenetic diseasesCMV