2017
A pooled analysis of dietary sugar/carbohydrate intake and esophageal and gastric cardia adenocarcinoma incidence and survival in the USA
Li N, Petrick JL, Steck SE, Bradshaw PT, McClain KM, Niehoff NM, Engel LS, Shaheen NJ, Risch HA, Vaughan TL, Wu AH, Gammon MD. A pooled analysis of dietary sugar/carbohydrate intake and esophageal and gastric cardia adenocarcinoma incidence and survival in the USA. International Journal Of Epidemiology 2017, 46: 1836-1846. PMID: 29040685, PMCID: PMC5837717, DOI: 10.1093/ije/dyx203.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAgedBlood GlucoseBody Mass IndexCase-Control StudiesDietary CarbohydratesDietary SucroseEsophageal NeoplasmsFemaleGastroesophageal RefluxHumansIncidenceLogistic ModelsMaleMiddle AgedMultivariate AnalysisNutrition AssessmentProportional Hazards ModelsRisk FactorsStomach NeoplasmsUnited StatesConceptsGastro-esophageal reflux diseaseBody mass indexCarbohydrate intakeAdenocarcinoma incidenceGCA incidenceOdds ratioUS population-based case-control studyStudy-specific food-frequency questionnairesPopulation-based case-control studyCox proportional hazards regressionGlycaemic indexDietary glycaemic indexFood frequency questionnaireProportional hazards regressionCase-control studyIntake of sucroseHigh glycaemic indexCarbohydrate measuresFrequency questionnaireHazard ratioReflux diseaseMass indexHazards regressionVital statusPooled analysis
2015
Dietary intake of flavonoids and oesophageal and gastric cancer: incidence and survival in the United States of America (USA)
Petrick JL, Steck SE, Bradshaw PT, Trivers KF, Abrahamson PE, Engel LS, He K, Chow WH, Mayne ST, Risch HA, Vaughan TL, Gammon MD. Dietary intake of flavonoids and oesophageal and gastric cancer: incidence and survival in the United States of America (USA). British Journal Of Cancer 2015, 112: 1291-1300. PMID: 25668011, PMCID: PMC4385952, DOI: 10.1038/bjc.2015.25.Peer-Reviewed Original ResearchConceptsOdds ratioHazard ratioFlavonoid intakeGastric cancerFood frequency questionnaire responsesMulticentre population-based studyIntake of anthocyanidinsLowest intake quartilesTotal flavonoid intakeFrequency-matched controlsPopulation-based studyProportional hazards regressionRisk of mortalityUSDA flavonoid databasesCase participantsAnthocyanidin intakeIntake quartilesHazards regressionVital statusDietary intakeChemopreventive effectsEpidemiologic studiesTumor typesFlavonoid databaseCancer
2013
Diet and lifestyle factors and risk of subtypes of esophageal and gastric cancers: classification tree analysis
Silvera S, Mayne ST, Gammon MD, Vaughan TL, Chow WH, Dubin JA, Dubrow R, Stanford JL, West AB, Rotterdam H, Blot WJ, Risch HA. Diet and lifestyle factors and risk of subtypes of esophageal and gastric cancers: classification tree analysis. Annals Of Epidemiology 2013, 24: 50-57. PMID: 24239095, PMCID: PMC4006990, DOI: 10.1016/j.annepidem.2013.10.009.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overCarcinoma, Squamous CellCase-Control StudiesConnecticutDietEsophageal NeoplasmsFeeding BehaviorFemaleGastroesophageal RefluxHumansIncidenceLife StyleLogistic ModelsMaleMiddle AgedNew JerseyRisk FactorsStatistics as TopicStomach NeoplasmsSurveys and QuestionnairesWashingtonYoung AdultConceptsImportant risk stratification factorRisk stratification factorsSquamous cell carcinomaRisk of subtypesGastric cardiaRisk factorsCell carcinomaGastric cancerStratification factorsPopulation-based case-control studyGastroesophageal reflux disease symptomsEsophageal squamous cell carcinomaGastroesophageal reflux diseaseCase-control studyInteraction of dietReflux diseaseLifestyle factorsWine intakeDietary factorsCancer sitesMedical factorsGastric sitesNoncitrus fruitClassification tree analysisCancer subtypes
2011
Nonsteroidal Anti-inflammatory Drug Use Reduces Risk of Adenocarcinomas of the Esophagus and Esophagogastric Junction in a Pooled Analysis
Liao LM, Vaughan TL, Corley DA, Cook MB, Casson AG, Kamangar F, Abnet CC, Risch HA, Giffen C, Freedman ND, Chow W, Sadeghi S, Pandeya N, Whiteman DC, Murray LJ, Bernstein L, Gammon MD, Wu AH. Nonsteroidal Anti-inflammatory Drug Use Reduces Risk of Adenocarcinomas of the Esophagus and Esophagogastric Junction in a Pooled Analysis. Gastroenterology 2011, 142: 442-452.e5. PMID: 22108196, PMCID: PMC3488768, DOI: 10.1053/j.gastro.2011.11.019.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdolescentAdultAgedAged, 80 and overAnticarcinogenic AgentsAnti-Inflammatory Agents, Non-SteroidalAustraliaCanadaCase-Control StudiesCohort StudiesEsophageal NeoplasmsEsophagogastric JunctionFemaleHumansLogistic ModelsMaleMiddle AgedOdds RatioRisk AssessmentRisk FactorsStomach NeoplasmsTime FactorsUnited StatesYoung AdultConceptsNonsteroidal anti-inflammatory drugsEsophagogastric junctional adenocarcinomaRisk of EACNSAID useEsophageal adenocarcinomaPooled analysisOdds ratioEsophagogastric junctionNonaspirin nonsteroidal anti-inflammatory drugsStudy-specific odds ratiosRandom-effects meta-analysis modelEffects meta-analysis modelPrevention of adenocarcinomaUse of aspirinSignificant reduced riskPopulation-based studyConfidence intervalsAnti-inflammatory drugsDuration of useEsophageal Adenocarcinoma ConsortiumMeta-analysis modelLogistic regression modelsJunctional adenocarcinomaMedication typeEAC riskPrincipal Component Analysis of Dietary and Lifestyle Patterns in Relation to Risk of Subtypes of Esophageal and Gastric Cancer
Silvera S, Mayne ST, Risch HA, Gammon MD, Vaughan T, Chow WH, Dubin JA, Dubrow R, Schoenberg J, Stanford JL, West AB, Rotterdam H, Blot WJ. Principal Component Analysis of Dietary and Lifestyle Patterns in Relation to Risk of Subtypes of Esophageal and Gastric Cancer. Annals Of Epidemiology 2011, 21: 543-550. PMID: 21435900, PMCID: PMC3109225, DOI: 10.1016/j.annepidem.2010.11.019.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedBody Mass IndexCase-Control StudiesConnecticutDietEsophageal NeoplasmsFemaleGastroesophageal RefluxHealth BehaviorHumansLife StyleLogistic ModelsMaleMiddle AgedNeoplasms, Squamous CellNew JerseyPrincipal Component AnalysisRegistriesRisk FactorsStomach NeoplasmsSurveys and QuestionnairesWashingtonConceptsEsophageal squamous cell carcinomaGastric cardia adenocarcinomaRisk of EACSmoking/alcoholGastroesophageal reflux diseaseEsophageal adenocarcinomaRisk factorsGastric cancerPopulation-based case-control studyRisk of ESCCFruit/vegetable intakeLifestyle patternsSquamous cell carcinomaRisk of subtypesCase-control studyFruits/vegetablesReflux diseaseLifestyle factorsVegetable scoresCell carcinomaVegetable intakeNitrite intakeAlcohol scoresCancer casesCancer riskPossible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer
Lochhead P, Ng MT, Hold GL, Rabkin CS, Vaughan TL, Gammon MD, Risch HA, Lissowska J, Mukhopadhya I, Chow WH, El-Omar EM. Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer. European Journal Of Cancer Prevention 2011, 20: 54-57. PMID: 21102338, PMCID: PMC3020097, DOI: 10.1097/cej.0b013e328341e320.Peer-Reviewed Original ResearchConceptsOesophageal cancerOdds ratioStudy populationCancer riskPopulation-based case-control studyUpper gastrointestinal cancer riskOesophageal squamous cell carcinomaGastrointestinal cancer riskWide association studies-identified single-nucleotide polymorphismsNoncardia gastric cancerSquamous cell carcinomaUpper gastrointestinal cancerCase-control studyColorectal cancer susceptibilitySecond study populationGastric cancer casesGastric cancer riskPotential confounding variablesFirst study populationCardia cancerCell carcinomaGastrointestinal cancerInverse associationCancer casesGastric cancer
2010
Cigarette Smoking and Adenocarcinomas of the Esophagus and Esophagogastric Junction: A Pooled Analysis From the International BEACON Consortium
Cook MB, Kamangar F, Whiteman DC, Freedman ND, Gammon MD, Bernstein L, Brown LM, Risch HA, Ye W, Sharp L, Pandeya N, Webb PM, Wu AH, Ward MH, Giffen C, Casson AG, Abnet CC, Murray LJ, Corley DA, Nyrén O, Vaughan TL, Chow WH. Cigarette Smoking and Adenocarcinomas of the Esophagus and Esophagogastric Junction: A Pooled Analysis From the International BEACON Consortium. Journal Of The National Cancer Institute 2010, 102: 1344-1353. PMID: 20716718, PMCID: PMC2935475, DOI: 10.1093/jnci/djq289.Peer-Reviewed Original ResearchConceptsSummary odds ratiosRisk of adenocarcinomaCigarette smokingSmoking cessationOdds ratioEsophagogastric junctional adenocarcinomaEsophagogastric junctionJunctional adenocarcinomaEsophageal adenocarcinomaPopulation-based case-control studyStrong dose-response associationStudy-specific odds ratiosMultivariable logistic regression modelInternational BEACON ConsortiumDose-response associationBody mass indexCigarette smoking cessationCase-control studyWhite non-Hispanic menEsophageal Adenocarcinoma ConsortiumNon-Hispanic menLogistic regression modelsGastroesophageal refluxCohort studyCurrent smokers
2009
IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas
Hoyo C, Schildkraut JM, Murphy SK, Chow W, Vaughan TL, Risch H, Marks JR, Jirtle RL, Calingeart B, Mayne S, Fraumeni J, Gammon MD. IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas. International Journal Of Cancer 2009, 125: 2673-2678. PMID: 19626700, PMCID: PMC3008656, DOI: 10.1002/ijc.24623.Peer-Reviewed Original ResearchConceptsNonsteroidal anti-inflammatory drugsRisk of esophagealInsulin-like growth factor 2Gastric adenocarcinomaGastric cancerEsophageal squamous cell carcinomaNoncardia gastric adenocarcinomaNoncardia gastric cancerSquamous cell carcinomaExploratory subgroup analysisAnti-inflammatory drugsMannose-6-phosphate/insulin-like growth factor 2 receptorNoncardia adenocarcinomaGrowth factor 2Cigarette smokersCell carcinomaSubgroup analysisGrowth factor 2 receptorInsulin-like growth factor 2 receptorCardia adenocarcinomaFactor 2 receptorG alleleNonsynonymous genetic variantsAdenocarcinomaStudy participantsCD14-159C/T and TLR9-1237T/C polymorphisms are not associated with gastric cancer risk in Caucasian populations
Hold GL, Rabkin CS, Gammon MD, Berry SH, Smith MG, Lissowska J, Risch HA, Chow WH, Mowat NA, Vaughan TL, El-Omar EM. CD14-159C/T and TLR9-1237T/C polymorphisms are not associated with gastric cancer risk in Caucasian populations. European Journal Of Cancer Prevention 2009, 18: 117-119. PMID: 19337058, PMCID: PMC2679029, DOI: 10.1097/cej.0b013e3283101292.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaCase-Control StudiesEsophageal NeoplasmsFemaleGene FrequencyGenetic Predisposition to DiseaseGenetics, PopulationHumansLinkage DisequilibriumLipopolysaccharide ReceptorsMalePolandPolymorphism, Single NucleotidePromoter Regions, GeneticRisk FactorsStomach NeoplasmsToll-Like Receptor 9United StatesWhite PeopleConceptsCD14-159C/TC promoter polymorphismCase-control studyGastric cancerPromoter polymorphismGastric cancer case-control studyTLR9 -1237T/C polymorphismPopulation-based case-control studyUpper gastrointestinal tract cancerHelicobacter pylori-induced gastritisCD14-159C/T polymorphismToll-like receptor signalingCaucasian populationFrequency-matched controlsGastrointestinal tract cancerPylori-induced gastritisUpper gastrointestinal tractCancer case-control studySingle nucleotide polymorphismsHost genetic factorsPotential confounding factorsGastric cancer riskTaiwanese Chinese populationGastric carcinoma casesNoncardia gastric carcinoma
2008
Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression
Figueroa JD, Terry MB, Gammon MD, Vaughan TL, Risch HA, Zhang FF, Kleiner DE, Bennett WP, Howe CL, Dubrow R, Mayne ST, Fraumeni JF, Chow WH. Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression. Cancer Causes & Control 2008, 20: 361-368. PMID: 18989634, PMCID: PMC2726999, DOI: 10.1007/s10552-008-9250-6.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAnti-Inflammatory Agents, Non-SteroidalBody Mass IndexCarcinoma, Squamous CellCardiaCase-Control StudiesConfidence IntervalsEsophageal NeoplasmsGastroesophageal RefluxHumansImmunohistochemistryLogistic ModelsMiddle AgedMulticenter Studies as TopicOdds RatioPopulation SurveillanceRisk FactorsSmokingStomach NeoplasmsTumor Suppressor Protein p53United StatesConceptsBody mass indexNon-steroidal anti-inflammatory drugsGastroesophageal reflux diseaseRisk factorsP53 overexpressionGastric cancerCigarette smokingReflux diseaseMass indexNon-steroidal anti-inflammatory drug useTumor subtypesPopulation-based case-control studyAnti-inflammatory drug useNon-cardia gastric adenocarcinomaGastro-esophageal reflux diseaseLarger body mass indexNon-cardia gastric cancerEsophageal squamous cell carcinomaTumor p53 overexpressionRisk factor profileSquamous cell carcinomaRisk of subtypesCase-control studyAnti-inflammatory drugsP53 protein overexpressionFood group intake and risk of subtypes of esophageal and gastric cancer
Silvera S, Mayne ST, Risch H, Gammon MD, Vaughan TL, Chow W, Dubrow R, Schoenberg JB, Stanford JL, West AB, Rotterdam H, Blot WJ, Fraumeni JF. Food group intake and risk of subtypes of esophageal and gastric cancer. International Journal Of Cancer 2008, 123: 852-860. PMID: 18537156, PMCID: PMC3008621, DOI: 10.1002/ijc.23544.Peer-Reviewed Original ResearchConceptsGastric cardia adenocarcinomaNoncardia gastric adenocarcinomaHigh-fat dairyFood group intakesCardia adenocarcinomaGastric adenocarcinomaEsophageal adenocarcinomaGroup intakesOdds ratioGastric cancerHigh intakePopulation-based case-control studyNon-cardia gastric adenocarcinomaEsophageal squamous cell carcinomaRed meatTotal meat intakeSquamous cell carcinomaTotal vegetable intakeRisk of subtypesEsophageal adenocarcinoma riskCase-control studyGastric cardiaAdenocarcinoma riskCell carcinomaRisk factors
2007
Alcohol dehydrogenase 3 and risk of esophageal and gastric adenocarcinomas
Terry MB, Gammon MD, Zhang FF, Vaughan TL, Chow WH, Risch HA, Schoenberg JB, Mayne ST, Stanford JL, West AB, Rotterdam H, Blot WJ, Fraumeni JF, Santella RM. Alcohol dehydrogenase 3 and risk of esophageal and gastric adenocarcinomas. Cancer Causes & Control 2007, 18: 1039-1046. PMID: 17665311, DOI: 10.1007/s10552-007-9046-0.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAlcohol DehydrogenaseAlcohol DrinkingAllelesCase-Control StudiesChi-Square DistributionConfidence IntervalsEsophageal NeoplasmsFemaleGene FrequencyGenotypeHomozygoteHumansInterviews as TopicLogistic ModelsMaleMiddle AgedOdds RatioPolymorphism, GeneticRisk FactorsStomach NeoplasmsUnited StatesConceptsRisk of esophagealEsophageal adenocarcinomaHigh riskGastric Cancer StudyGastric cardia adenocarcinomaGastric adenocarcinomaCarcinoma riskConclusionThese dataCancer riskCardia adenocarcinomaTumor typesAdenocarcinomaAlcohol dehydrogenase 3Common polymorphismsEsophagealRisk estimatesCancer studiesRiskAlcohol dehydrogenase 3 geneDrinkersDehydrogenase 3PolymorphismNondrinkersMethodsWeGenotypesGST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas
Wideroff L, Vaughan TL, Farin FM, Gammon MD, Risch H, Stanford JL, Chow WH. GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas. Cancer Epidemiology 2007, 31: 233-236. PMID: 17646057, PMCID: PMC2268246, DOI: 10.1016/j.cdp.2007.03.004.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAllelesArylamine N-AcetyltransferaseCase-Control StudiesCytochrome P-450 CYP1A1Esophageal NeoplasmsFemaleGenetic Predisposition to DiseaseGlutathione S-Transferase piGlutathione TransferaseHumansIsoenzymesMaleMiddle AgedOdds RatioPolymerase Chain ReactionPolymorphism, GeneticRisk FactorsStomach NeoplasmsUnited StatesConceptsGastric adenocarcinomaOdds ratioGastric cardia adenocarcinomaEsophageal adenocarcinomaCardia adenocarcinomaElevated riskConfidence intervalsVal genotypePopulation-based case-control studyCYP1A1 Val/ValGSTP1 Val/Val genotypeNoncardia gastric adenocarcinomaEpidemiologic risk factorsRespective odds ratiosRisk of esophagealIle/Val genotypeVal/Val genotypeCase-control studyVal/ValN-acetyltransferase 1Same catchment areaHistologic subgroupsIncident casesRisk factorsGSTT1 genotype
2006
A Functional Polymorphism of Toll-Like Receptor 4 Gene Increases Risk of Gastric Carcinoma and Its Precursors
Hold GL, Rabkin CS, Chow W, Smith MG, Gammon MD, Risch HA, Vaughan TL, McColl KE, Lissowska J, Zatonski W, Schoenberg JB, Blot WJ, Mowat NA, Fraumeni JF, El–Omar E. A Functional Polymorphism of Toll-Like Receptor 4 Gene Increases Risk of Gastric Carcinoma and Its Precursors. Gastroenterology 2006, 132: 905-912. PMID: 17324405, DOI: 10.1053/j.gastro.2006.12.026.Peer-Reviewed Original ResearchMeSH KeywordsAchlorhydriaCarcinomaCase-Control StudiesCohort StudiesEuropeFemaleGastritis, AtrophicGene Expression Regulation, NeoplasticGene FrequencyGenetic Predisposition to DiseaseGenotypeHelicobacter InfectionsHelicobacter pyloriHumansLogistic ModelsMaleOdds RatioPhenotypePolymorphism, GeneticPopulation SurveillancePrecancerous ConditionsRegistriesRisk AssessmentRisk FactorsStomach NeoplasmsToll-Like Receptor 4United StatesConceptsH pylori infectionGastric carcinoma patientsNoncardia gastric carcinomaOdds ratioGastric carcinomaCardia carcinomaGastric atrophyCarcinoma patientsPylori infectionG polymorphismPopulation-based case-control studyUpper gastrointestinal tract cancerSevere gastric atrophyFrequency-matched controlsGastric acid outputGastrointestinal tract cancerGastric cancer patientsGastric cardia carcinomaCase-control studyEsophageal squamous cellsPotential confounding factorsGastric carcinoma casesGastric changesTract cancerAcid outputCarbonated Soft Drink Consumption and Risk of Esophageal Adenocarcinoma
Mayne ST, Risch HA, Dubrow R, Chow WH, Gammon MD, Vaughan TL, Borchardt L, Schoenberg JB, Stanford JL, West AB, Rotterdam H, Blot WJ, Fraumeni JF. Carbonated Soft Drink Consumption and Risk of Esophageal Adenocarcinoma. Journal Of The National Cancer Institute 2006, 98: 72-75. PMID: 16391374, DOI: 10.1093/jnci/djj007.Peer-Reviewed Original ResearchConceptsCSD consumptionEsophageal adenocarcinomaCarbonated soft drinksRisk factorsOdds ratioPopulation-based case-control studyEsophageal adenocarcinoma incidenceEsophageal adenocarcinoma riskCase-control studySoft drink consumptionGastric cancer subtypesCarbonated soft drink consumptionU.S. multicenterGastroesophageal refluxAdenocarcinoma incidenceAdenocarcinoma riskIncidence rateLowest quartileGastric cancerDrink consumptionCancer subtypesAdenocarcinomaRiskSoft drinksIntake
2005
Demographic and lifestyle predictors of survival in patients with esophageal or gastric cancers
Trivers KF, de Roos AJ, Gammon MD, Vaughan TL, Risch HA, Olshan AF, Schoenberg JB, Mayne ST, Dubrow R, Stanford JL, Abrahamson P, Rotterdam H, West AB, Fraumeni JF, Chow WH. Demographic and lifestyle predictors of survival in patients with esophageal or gastric cancers. Clinical Gastroenterology And Hepatology 2005, 3: 225-230. PMID: 15765441, DOI: 10.1016/s1542-3565(04)00613-5.Peer-Reviewed Original ResearchConceptsBody mass indexEsophageal squamous cell carcinomaGastric cancerHazard ratioLonger survivalNonsteroidal anti-inflammatory drug usePopulation-based case-control studyAnti-inflammatory drug usePrediagnosis body mass indexAdjusted hazard ratioGastroesophageal reflux diseaseSquamous cell carcinomaConfidence intervalsGastric cancer survivalCase-control studyEsophageal adenocarcinoma patientsLocalized diseaseReflux diseaseMass indexAlcohol intakeCigarette smokingDecreased riskIncident casesAdenocarcinoma patientsCell carcinoma
2004
Nonsteroidal Anti-inflammatory Drug Use Associated with Reduced Incidence of Adenocarcinomas of the Esophagus and Gastric Cardia that Overexpress Cyclin D1A Population-Based Study
Gammon MD, Terry MB, Arber N, Chow WH, Risch HA, Vaughan TL, Schoenberg JB, Mayne ST, Stanford JL, Dubrow R, Rotterdam H, West AB, Fraumeni JF, Weinstein IB, Hibshoosh H. Nonsteroidal Anti-inflammatory Drug Use Associated with Reduced Incidence of Adenocarcinomas of the Esophagus and Gastric Cardia that Overexpress Cyclin D1A Population-Based Study. Cancer Epidemiology Biomarkers & Prevention 2004, 13: 34-39. PMID: 14744730, DOI: 10.1158/1055-9965.epi-03-0198.Peer-Reviewed Original ResearchConceptsCyclin D1 statusOdds ratioCyclin D1NSAID useGastric cardiaRisk factorsCase groupD1 tumorsNonsteroidal anti-inflammatory drug usePopulation-based case-control studyAnti-inflammatory drug useMultivariate-adjusted odds ratioEsophageal squamous cell carcinomaNoncardia gastric adenocarcinomaUse of aspirinSquamous cell carcinomaGastric cancer patientsCase-control studyGastric cardia adenocarcinomaCigarette smokingCell carcinomaCancer patientsGastric adenocarcinomaEsophageal adenocarcinomaReduced incidence
2003
Population Attributable Risks of Esophageal and Gastric Cancers
Engel LS, Chow W, Vaughan TL, Gammon MD, Risch HA, Stanford JL, Schoenberg JB, Mayne ST, Dubrow R, Rotterdam H, West AB, Blaser M, Blot WJ, Gail MH, Fraumeni JF. Population Attributable Risks of Esophageal and Gastric Cancers. Journal Of The National Cancer Institute 2003, 95: 1404-1413. PMID: 13130116, DOI: 10.1093/jnci/djg047.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAlcohol DrinkingBody Mass IndexCarcinoma, Squamous CellCardiaCase-Control StudiesConfounding Factors, EpidemiologicEnzyme-Linked Immunosorbent AssayEsophageal NeoplasmsFeeding BehaviorFemaleFruitGastroesophageal RefluxHumansLife StyleMaleMiddle AgedNitritesObesityRisk AssessmentRisk FactorsSmokingStomach NeoplasmsStomach UlcerUnited StatesVegetablesConceptsCombined population attributable riskPopulation attributable riskNoncardia gastric adenocarcinomaEsophageal squamous cell carcinomaSquamous cell carcinomaGastric cardia adenocarcinomaBody mass indexGastric adenocarcinomaRisk factorsCell carcinomaCardia adenocarcinomaGastroesophageal refluxMass indexPylori infectionAttributable riskEsophageal adenocarcinomaGastric cancerVegetable consumptionMulticenter population-based case-control studyPopulation-based case-control studyPrevalence of smokingH. pylori infectionHelicobacter pylori infectionCase-control studyLow fruitRe: Cancer Risks in BRCA1 Carriers: Time for the Next Generation of Studies
Risch HA, Narod SA. Re: Cancer Risks in BRCA1 Carriers: Time for the Next Generation of Studies. Journal Of The National Cancer Institute 2003, 95: 758-758. PMID: 12759395, DOI: 10.1093/jnci/95.10.758.Peer-Reviewed Original ResearchIncreased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms
El-Omar EM, Rabkin CS, Gammon MD, Vaughan TL, Risch HA, Schoenberg JB, Stanford JL, Mayne ST, Goedert J, Blot WJ, Fraumeni JF, Chow WH. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology 2003, 124: 1193-1201. PMID: 12730860, DOI: 10.1016/s0016-5085(03)00157-4.Peer-Reviewed Original ResearchConceptsProinflammatory cytokine gene polymorphismsNoncardia gastric cancerUpper gastrointestinal cancerCytokine gene polymorphismsGastric cancerIL-10Gastrointestinal cancerReceptor antagonistGene polymorphismsPopulation-based case-control studyCytokine genesTumor necrosis factor AAnti-inflammatory cytokine genesIL-1 receptor antagonistGastric H. pylori infectionEsophageal squamous cell carcinomaHelicobacter pylori-related gastric cancerTumor necrosis factor alphaNoncardia gastric adenocarcinomaIL-1 gene clusterFrequency-matched controlsSquamous cell carcinomaH. pylori infectionGastric cardia cancerCase-control study