Health-Related Behaviors and Risk of Common Age-Related Brain Diseases Across Severities of Genetic Risk
Marini S, Kimball T, Mayerhofer E, Tack R, Senff J, Prapiadou S, Rivier C, Duskin J, Kourkoulis C, Falcone G, Yechoor N, Tanzi R, Rosand J, Singh S, Parodi L, Anderson C. Health-Related Behaviors and Risk of Common Age-Related Brain Diseases Across Severities of Genetic Risk. Neurology 2024, 103: e210014. PMID: 39504504, DOI: 10.1212/wnl.0000000000210014.Peer-Reviewed Original ResearchConceptsLate-life depressionGenetic riskDementia riskUK Biobank (UKBEffects of healthy lifestylesHealth-related behaviorsGenetic predispositionElevated genetic riskProspective cohort studyHazard of strokeCox proportional hazards modelsAge-related brain diseasesLifestyle behaviorsCare scoresUKB participantsProportional hazards modelHealthy lifestyleIncidence of strokeMultivariate Cox proportional hazards modelPolygenic scoresTargeted interventionsLifestyle adjustmentsAggregate risk estimatesRisk estimatesCohort studyLife's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, Hawkes M, de Havenon A, Schwamm L, Sheth K, Gill T, Falcone G. Life's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults. Neurology 2024, 103: e209990. PMID: 39442069, PMCID: PMC11498939, DOI: 10.1212/wnl.0000000000209990.Peer-Reviewed Original ResearchConceptsLife's Essential 8Poor cardiovascular healthCardiovascular healthBrain healthLife's Essential 8 scoreUnadjusted riskEssential 8Determinants of cardiovascular healthUK Biobank (UKBCardiovascular health profileModifiable cardiovascular risk factorsBrain health outcomesRisk factorsComposite outcomePublic health constructsPopulation studiesMiddle-aged adultsCox modelLate-life depressionCox proportional hazards modelsBrain health benefitsMultivariate Cox modelCardiovascular risk factorsFollow-up timeAoU participantsThe predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort
Singh S, Rivier C, Papier K, Chemali Z, Gutierrez-Martinez L, Parodi L, Mayerhofer E, Senff J, Clocchiatti-Tuozzo S, Nunley C, Newhouse A, Ouyang A, Westover M, Tanzi R, Lazar R, Pikula A, Ibrahim S, Brouwers H, Howard V, Howard G, Yechoor N, Littlejohns T, Sheth K, Rosand J, Fricchione G, Anderson C, Falcone G. The predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort. Frontiers In Psychiatry 2024, 15: 1373797. PMID: 39109366, PMCID: PMC11301016, DOI: 10.3389/fpsyt.2024.1373797.Peer-Reviewed Original ResearchIncident late-life depressionLate-life depressionBrain health outcomesCare scoresHealth outcomesHealthy lifestyle choicesOutcome of dementiaUK Biobank cohortRisk factorsComposite outcomeCox proportional hazards modelsCare providersBiobank cohortProportional hazards modelIncident casesMultivariate Cox proportional hazards modelRisk of strokeLifestyle changesClinical careLifestyle choicesDementiaBrain healthFuture depressionBaseline evaluationComplete dataAPOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study
Clocchiatti‐Tuozzo S, Szejko N, Rivier C, Renedo D, Huo S, Sheth K, Gill T, Falcone G. APOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study. Journal Of The American Geriatrics Society 2024, 72: 2989-2999. PMID: 38946154, PMCID: PMC11461103, DOI: 10.1111/jgs.19043.Peer-Reviewed Original ResearchRisk of dementiaOutcome of dementiaAssociated with lower riskOlder adultsRetirement StudySecondary analysisEffects of tested interventionsHealth and Retirement StudyClinical trials of older adultsApo E4Composite outcomePrimary analysisHigh riskLow riskCox proportional hazards modelsProportional hazards modelMultivariate Cox proportional hazards modelDementiaAPOE genotypeClinical trialsHazards modelDisabilityParticipantsFunctional outcomesHeart diseaseRadiomic Features of Acute Cerebral Hemorrhage on Non-Contrast CT Associated with Patient Survival
Zaman S, Dierksen F, Knapp A, Haider S, Karam G, Qureshi A, Falcone G, Sheth K, Payabvash S. Radiomic Features of Acute Cerebral Hemorrhage on Non-Contrast CT Associated with Patient Survival. Diagnostics 2024, 14: 944. PMID: 38732358, PMCID: PMC11083693, DOI: 10.3390/diagnostics14090944.Peer-Reviewed Original ResearchInternational Normalized RatioArea under the curveNational Institutes of Health Stroke ScaleIntracerebral hemorrhageRadiomic featuresAntihypertensive Treatment of Acute Cerebral Hemorrhage IINon-contrast head CT scanBaseline International Normalized RatioAssociated with worse survival outcomesAcute intracerebral hemorrhageSupratentorial intracerebral hemorrhageWorse survival outcomesKaplan-Meier analysisHead CT scanCox proportional hazards modelsPredictors of mortalityAcute cerebral hemorrhageReceiver Operating Characteristic (ROC) analysisFirst-order energyHigher mortality riskProportional hazards modelHealth Stroke ScaleCT radiomicsHematoma expansionPost-ICH