2009
Conserved Telomere Maintenance Component 1 Interacts with STN1 and Maintains Chromosome Ends in Higher Eukaryotes
Surovtseva Y, Churikov D, Boltz K, Song X, Lamb J, Warrington R, Leehy K, Heacock M, Price C, Shippen D. Conserved Telomere Maintenance Component 1 Interacts with STN1 and Maintains Chromosome Ends in Higher Eukaryotes. Molecular Cell 2009, 36: 207-218. PMID: 19854131, PMCID: PMC2768651, DOI: 10.1016/j.molcel.2009.09.017.Peer-Reviewed Original ResearchMeSH KeywordsAnaphaseArabidopsisArabidopsis ProteinsCell Line, TumorChromosomal Proteins, Non-HistoneChromosomes, PlantConserved SequenceEukaryotic CellsGenomic InstabilityHumansIn Situ Hybridization, FluorescenceMutationNucleic Acid ConformationProtein BindingRecombination, GeneticTelomereTelomere-Binding ProteinsConceptsG-overhangsOB-fold domainDNA damage responseArabidopsis mutantsMulticellular organismsHigher eukaryotesTEN1 (CST) complexChromosome endsHuman CTC1Telomere integrityTelomere maintenanceDiverse speciesDamage responseEnd fusionsChromatin bridgesTelomere lossRNAi triggersDevelopmental defectsCTC1Stn1PlantsEukaryotesOrthologsVertebratesMutants
2008
STN1 protects chromosome ends in Arabidopsis thaliana
Song X, Leehy K, Warrington R, Lamb J, Surovtseva Y, Shippen D. STN1 protects chromosome ends in Arabidopsis thaliana. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 19815-19820. PMID: 19064932, PMCID: PMC2604966, DOI: 10.1073/pnas.0807867105.Peer-Reviewed Original ResearchConceptsChromosome end protectionEnd chromosome fusionsOligonucleotide/oligosaccharideSignificant sequence similarityDNA repair machineryDouble-strand breaksDistinct subcomplexesMulticellular eukaryotesTelomere capChromosome fusionsArabidopsis thalianaTelomere proteinsChromosome endsSubtelomeric DNASchizosaccharomyces pombeShelterin componentsTelomere integrityVertebrate telomeresRepair machinerySequence similarityNucleolytic attackTelomere recombinationEnd protectionDevelopmental defectsStn1
2007
Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance
Surovtseva Y, Shakirov E, Vespa L, Osbun N, Song X, Shippen D. Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance. The EMBO Journal 2007, 26: 3653-3661. PMID: 17627276, PMCID: PMC1949013, DOI: 10.1038/sj.emboj.7601792.Peer-Reviewed Original ResearchConceptsTelomere length regulationLength regulationChromosome end protectionSingle-copy geneNovel accessory factorTelomerase RNPTelomere proteinsTelomere maintenanceSequence similarityTelomeric DNAAccessory factorsEnd protectionTelomerase enzymeGenetic analysisSame pathwayUnsynchronized cellsS phaseRapid evolutionTelomerase activityTelomeraseTelomeresGenesProteinRegulationPOT1
2005
The Arabidopsis Pot1 and Pot2 Proteins Function in Telomere Length Homeostasis and Chromosome End Protection
Shakirov E, Surovtseva Y, Osbun N, Shippen D. The Arabidopsis Pot1 and Pot2 Proteins Function in Telomere Length Homeostasis and Chromosome End Protection. Molecular And Cellular Biology 2005, 25: 7725-7733. PMID: 16107718, PMCID: PMC1190295, DOI: 10.1128/mcb.25.17.7725-7733.2005.Peer-Reviewed Original ResearchConceptsChromosome end protectionTelomere length homeostasisEnd protectionLength homeostasisGenome instabilityWild typePot1-like proteinsSevere growth defectOligonucleotide/oligosaccharideMassive genome instabilityBulk telomeresTransgenic plantsGrowth defectProtein functionPositive regulationN-terminusBinding proteinAnalogous regionMutantsArabidopsisPlantsLength controlCorresponding regionPOT1Protein
2004
A C-terminal Myb Extension Domain Defines a Novel Family of Double-strand Telomeric DNA-binding Proteins in Arabidopsis *
Karamysheva Z, Surovtseva Y, Vespa L, Shakirov E, Shippen D. A C-terminal Myb Extension Domain Defines a Novel Family of Double-strand Telomeric DNA-binding Proteins in Arabidopsis *. Journal Of Biological Chemistry 2004, 279: 47799-47807. PMID: 15364931, DOI: 10.1074/jbc.m407938200.Peer-Reviewed Original ResearchConceptsPlant telomeric DNATelomeric DNA bindingDNA bindingTelomeric DNASingle Myb-like domainTelomeric DNA-binding proteinMyb-like domainDistinct gene familiesGenome data baseDNA-binding proteinsSearch of genesRegion C-terminalFamily 2Isolated C-terminal fragmentFamily 1Plant telomeresMyb domainArabidopsis genesGene familyC-terminal fragmentImmunoprecipitation experimentsC-terminusRecombinant proteinsC-terminalProtein composition