2024
Multi-Omics Analysis of Gut Microbiota and Host Transcriptomics Reveal Dysregulated Immune Response and Metabolism in Young Adults with Irritable Bowel Syndrome
Chen J, Zhao T, Li H, Xu W, Maas K, Singh V, Chen M, Dorsey S, Starkweather A, Cong X. Multi-Omics Analysis of Gut Microbiota and Host Transcriptomics Reveal Dysregulated Immune Response and Metabolism in Young Adults with Irritable Bowel Syndrome. International Journal Of Molecular Sciences 2024, 25: 3514. PMID: 38542485, PMCID: PMC10970623, DOI: 10.3390/ijms25063514.Peer-Reviewed Original ResearchMeSH KeywordsFecesFirmicutesGastrointestinal MicrobiomeGene Expression ProfilingHumansImmunityIrritable Bowel SyndromeMultiomicsYoung AdultConceptsGut microbiotaIrritable bowel syndrome subjectsHost transcriptomeIrritable bowel syndromeMetabolic pathways of gut microbiotaTranscriptome profilingAnalysis of gut microbiotaDysbiosis of gut microbiotaDysregulated immune responseRNA-seq dataHealthy controlsMulti-omics analysisImmune responseImmune system processRNA-seqGene OntologyBowel syndromeIBS participantsMulti-omicsMicrobiotaMetabolic pathwaysPathways of antigen processingPeripheral blood samplesGutStool samples
2022
Somatosensory Profiles Differentiate Pain and Psychophysiological Symptoms Among Young Adults With Irritable Bowel Syndrome
Chen J, Zhang Y, Barandouzi Z, Xu W, Feng B, Chon K, Santos M, Starkweather A, Cong X. Somatosensory Profiles Differentiate Pain and Psychophysiological Symptoms Among Young Adults With Irritable Bowel Syndrome. The Clinical Journal Of Pain 2022, 38: 492-501. PMID: 35686579, PMCID: PMC9205184, DOI: 10.1097/ajp.0000000000001046.Peer-Reviewed Original ResearchMeSH KeywordsCluster AnalysisHumansIrritable Bowel SyndromeNociceptive PainPain MeasurementPain ThresholdYoung AdultConceptsIrritable bowel syndromeIrritable bowel syndrome patientsHealthy controlsPain intensityPain thresholdBowel syndromeIBS-related painSomatic pain perceptionQuantitative sensory testingIncreased pain thresholdYoung adultsRandomized clinical trialsSelf-management interventionsSomatosensory profilesDifferentiate painPain perceptionPsychophysiological symptomsFollow-upClinical trialsPainNormal thresholdsIncreased thresholdSensory thresholdsSevere symptomsPatientsThe effect of self-management online modules plus nurse-led support on pain and quality of life among young adults with irritable bowel syndrome: A randomized controlled trial
Chen J, Zhang Y, Barandouzi Z, Lee J, Zhao T, Xu W, Chen M, Feng B, Starkweather A, Cong X. The effect of self-management online modules plus nurse-led support on pain and quality of life among young adults with irritable bowel syndrome: A randomized controlled trial. International Journal Of Nursing Studies 2022, 132: 104278. PMID: 35640500, PMCID: PMC10588769, DOI: 10.1016/j.ijnurstu.2022.104278.Peer-Reviewed Original ResearchMeSH KeywordsChronic PainHumansIrritable Bowel SyndromeNurse's RoleQuality of LifeSelf-ManagementYoung AdultConceptsQuality of lifeImprove quality of lifeNurse-led interventionNurse-ledIntervention groupIntervention effectsPain interferenceOnline modulesImprove qualitySelf-managementNurse-led self-management programIrritable bowel syndromeYoung adultsSelf-efficacyNurse-led supportEffects of self-managementLife-long self-managementSelf-management programReducing pain interferenceSelf-reported painFollow-upIncreased quality of lifeBaseline data collectionIncreased self-efficacyDecreased pain intensityAssociations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome
Barandouzi Z, Lee J, del Carmen Rosas M, Chen J, Henderson W, Starkweather A, Cong X. Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome. Scientific Reports 2022, 12: 1648. PMID: 35102266, PMCID: PMC8803858, DOI: 10.1038/s41598-022-05756-0.Peer-Reviewed Original ResearchConceptsEmotional distressNeurotransmitter levelsHealthy controlsIrritable bowel syndrome groupIrritable bowel syndromeRegulation of neurotransmittersDepressive symptomsSerotonin levelsGut-brain axisEmotional symptomsHC groupPlasma neurotransmittersDistressGut microbiome profilesNeurotransmitterGut microbiomeNorepinephrine levelsBowel syndromeMicrobiome profilesPersonsNorepinephrineNested case-control studySymptomsCase-control studySerotoninPsychosocial and Sensory Factors Contribute to Self-Reported Pain and Quality of Life in Young Adults with Irritable Bowel Syndrome
Chen J, Barandouzi Z, Lee J, Xu W, Feng B, Starkweather A, Cong X. Psychosocial and Sensory Factors Contribute to Self-Reported Pain and Quality of Life in Young Adults with Irritable Bowel Syndrome. Pain Management Nursing 2022, 23: 646-654. PMID: 35074280, PMCID: PMC9300766, DOI: 10.1016/j.pmn.2021.12.004.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal PainCross-Sectional StudiesFatigueFemaleHumansIrritable Bowel SyndromeMaleQuality of LifeSelf ReportYoung AdultConceptsSelf-reported painQuality of lifePressure pain thresholdBrief Pain InventoryPsychosocial factorsSelf-efficacyPain interferenceIBS-QOLIrritable bowel syndromeAssociated with pain interferenceCross-sectional analysis of baseline dataPain thresholdAnalysis of baseline dataYoung adultsImprove pain managementMediation analysisCross-sectional analysisSensory factorsRandomized controlled trialsPain InventoryPain managementIntervention studiesAlcohol intakeCold pain thresholdGeneral community
2018
Pain self‐management plus nurse‐led support in young adults with irritable bowel syndrome: Study protocol for a pilot randomized control trial
Cong X, Ramesh D, Perry M, Xu W, Bernier K, Young E, Walsh S, Starkweather A. Pain self‐management plus nurse‐led support in young adults with irritable bowel syndrome: Study protocol for a pilot randomized control trial. Research In Nursing & Health 2018, 41: 121-130. PMID: 29388674, PMCID: PMC6415297, DOI: 10.1002/nur.21862.Peer-Reviewed Original ResearchConceptsQuality of lifeSM interventionsHealth outcomesSelf-managementIrritable bowel syndromeNurse-led supportSM behaviorSelf-management instructionsLongitudinal pilot studyYoung adultsPreliminary effectivenessPain neurophysiologyPhone consultationsDistressing symptomsEarly adult yearsBowel syndromePrimary outcomeStudy protocolVideo modulesWell-beingSeverity of symptomsPilot studyAdult yearsInterventionPain
2017
Effects of Self-Management Interventions in Patients With Irritable Bowel Syndrome: Systematic Review
Cong X, Perry M, Bernier K, Young E, Starkweather A. Effects of Self-Management Interventions in Patients With Irritable Bowel Syndrome: Systematic Review. Western Journal Of Nursing Research 2017, 40: 1698-1720. PMID: 28854852, PMCID: PMC5794643, DOI: 10.1177/0193945917727705.Peer-Reviewed Original ResearchMeSH KeywordsCognitive Behavioral TherapyExerciseHumansIrritable Bowel SyndromeQuality of LifeSelf-ManagementConceptsSelf-management interventionsEffectiveness of self-management interventionsQuality of lifeIrritable bowel syndromeSymptom self-management strategiesSystematic reviewExercise-based interventionsMeasures of quality of lifeSelf-management strategiesHealth care providersTracking long-term outcomesImprove quality of lifeSymptom measuresSymptom managementCare providersGroup interventionCognitive-behavioral therapyBowel syndromeImprove qualityInterventionWeb-basedPediatric populationCost conditionsLong-term outcomesSymptoms