2006
Effects of hypoglycemia on human brain activation measured with fMRI
Anderson AW, Heptulla RA, Driesen N, Flanagan D, Goldberg PA, Jones TW, Rife F, Sarofin H, Tamborlane W, Sherwin R, Gore JC. Effects of hypoglycemia on human brain activation measured with fMRI. Magnetic Resonance Imaging 2006, 24: 693-697. PMID: 16824963, DOI: 10.1016/j.mri.2006.03.013.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingBrain activationHuman brain activationPassive sensory stimulationCognitive tasksFMRI activityVisual stimuliEuglycemic clamp studiesBlood glucose levelsLevel-dependent contrastEffects of hypoglycemiaBOLD signalSensory stimulationHealthy human subjectsVisual stimulationMagnetic resonance imagingHyperinsulinemic hypoglycemicHealthy brainAcute hypoglycemiaGlucose levelsClamp studiesResonance imagingFractional signal changeHypoglycemiaEuglycemia
1993
Effect of caffeine on the recognition of and responses to hypoglycemia in humans.
Kerr D, Sherwin RS, Pavalkis F, Fayad PB, Sikorski L, Rife F, Tamborlane WV, During MJ. Effect of caffeine on the recognition of and responses to hypoglycemia in humans. Annals Of Internal Medicine 1993, 119: 799-804. PMID: 8379601, DOI: 10.7326/0003-4819-119-8-199310150-00005.Peer-Reviewed Original ResearchConceptsGlucose levelsHypoglycemic symptomsCaffeine consumptionCounter-regulatory hormone levelsHyperinsulinemic glucose clamp techniqueMiddle cerebral artery velocityLarge carbohydrate loadCerebral artery velocityAcute caffeine ingestionClinical Research CenterLevels of norepinephrineAwareness of hypoglycemiaCerebral blood flowDouble-blind designGlucose clamp techniqueLate postprandial periodPlasma glucose levelsLevels of epinephrineBrain glucose useCaffeine-free colaEffects of caffeineAcute ingestionSympathoadrenal activationArtery velocityPlasma glucose
1991
Opiate blockade enhances hypoglycemic counterregulation in normal and insulin-dependent diabetic subjects
Caprio S, Gerety G, Tamborlane WV, Jones T, Diamond M, Jacob R, Sherwin RS. Opiate blockade enhances hypoglycemic counterregulation in normal and insulin-dependent diabetic subjects. American Journal Of Physiology 1991, 260: e852-e858. PMID: 2058661, DOI: 10.1152/ajpendo.1991.260.6.e852.Peer-Reviewed Original ResearchConceptsInsulin-induced hypoglycemiaGlucose counterregulationIDDM patientsGlucose productionOpiate blockadeHormonal responsesInsulin-dependent diabetic subjectsCounterregulatory hormone releaseDefective glucose counterregulationInsulin clamp studiesAbsence of hypoglycemiaInsulin-dependent patientsVariable glucose infusionDefective counterregulationHypoglycemic counterregulationNaloxone studyGlucagon responseDiabetic subjectsEndogenous opiatesGlucoregulatory hormonesGlucoregulatory responsesHormone releaseGlucose infusionHealthy subjectsCortisol release
1985
Intensive insulin therapy reduces counterregulatory hormone responses to hypoglycemia in patients with type I diabetes.
Simonson DC, Tamborlane WV, DeFronzo RA, Sherwin RS. Intensive insulin therapy reduces counterregulatory hormone responses to hypoglycemia in patients with type I diabetes. Annals Of Internal Medicine 1985, 103: 184-90. PMID: 3893253, DOI: 10.7326/0003-4819-103-2-184.Peer-Reviewed Original ResearchConceptsCounterregulatory hormone responsesPump treatmentHormone responseCounterregulatory hormone releaseInsulin pump treatmentPerception of hypoglycemiaIntensive insulin therapyIntensive insulin treatmentInsulin clamp techniqueType IBlood glucose levelsCounterregulatory hormonesGlucose counterregulationInsulin therapyHypoglycemic stimulusHypoglycemic episodesGlucagon releaseHealthy controlsInsulin treatmentHormone releaseStudy groupGlucose levelsHypoglycemic periodNormal controlsHypoglycemia
1983
Effect of growth hormone on oral glucose tolerance and circulating metabolic fuels in man
Sherwin RS, Schulman GA, Hendler R, Walesky M, Belous A, Tamborlane W. Effect of growth hormone on oral glucose tolerance and circulating metabolic fuels in man. Diabetologia 1983, 24: 155-161. PMID: 6341144, DOI: 10.1007/bf00250154.Peer-Reviewed Original ResearchConceptsGrowth hormone excessNon-esterified fatty acidsGrowth hormoneHormone excessHigher plasma insulin concentrationsOral glucose toleranceInsulin antagonistic effectsGrowth hormone infusionHigher insulin levelsInfusion of cortisolPlasma insulin concentrationOral glucoseGlucose intoleranceGlucose toleranceSomatomedin concentrationsInsulin levelsFatty acidsHormone infusionPlasma glucoseHyperglycaemic responseInsulin concentrationsNormal suppressionGlucose curveGlucose levelsNormal subjects