1994
Comparison of the metabolic effects of recombinant human insulin-like growth factor-I and insulin. Dose-response relationships in healthy young and middle-aged adults.
Boulware SD, Tamborlane WV, Rennert NJ, Gesundheit N, Sherwin RS. Comparison of the metabolic effects of recombinant human insulin-like growth factor-I and insulin. Dose-response relationships in healthy young and middle-aged adults. Journal Of Clinical Investigation 1994, 93: 1131-1139. PMID: 8132753, PMCID: PMC294058, DOI: 10.1172/jci117065.Peer-Reviewed Original ResearchConceptsRecombinant human insulin-like growth factorInsulin-like growth factorHuman insulin-like growth factorMiddle-aged subjectsC-peptideYoung subjectsBasal IGF-I levelsHealthy middle-aged subjectsGlucose uptakeGrowth factorAdverse metabolic changesFree fatty acid levelsIGF-I levelsRelative insulin deficiencyEuglycemic clamp studiesFat oxidation rateDose-response relationshipFatty acid levelsInsulin-induced stimulationMiddle-aged adultsBasal insulinInsulin deficiencyMetabolic effectsClamp studiesRhIGF
1988
Insulin Resistance and Hyperinsulinemia in Patients with Thalassemia Major Treated by Hypertransfusion
Merkel PA, Simonson DC, Amiel SA, Plewe G, Sherwin RS, Pearson HA, Tamborlane WV. Insulin Resistance and Hyperinsulinemia in Patients with Thalassemia Major Treated by Hypertransfusion. New England Journal Of Medicine 1988, 318: 809-814. PMID: 3281000, DOI: 10.1056/nejm198803313181303.Peer-Reviewed Original ResearchConceptsInsulin resistanceInsulin levelsThalassemia majorInsulin-stimulated glucose metabolismC-peptide levelsDevelopment of diabetesOral glucose administrationPlasma insulin levelsHypertransfusion therapyPubertal patientsPrepubertal patientsDiabetes mellitusGlucose toleranceInsulin deficiencyPubertal childrenGlucose administrationInsulin secretionIron overloadPrepubertal childrenChelation therapyPubertal subjectsGlucose metabolismBeta cellsHyperglycemic stimulusPatients