2023
Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions
Kaffe E, Roulis M, Zhao J, Qu R, Sefik E, Mirza H, Zhou J, Zheng Y, Charkoftaki G, Vasiliou V, Vatner D, Mehal W, AlcHepNet, Kluger Y, Flavell R. Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions. Cell 2023, 186: 3793-3809.e26. PMID: 37562401, PMCID: PMC10544749, DOI: 10.1016/j.cell.2023.07.017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEndothelial CellsFibrosisHepatocytesHumansKupffer CellsLiverMiceNon-alcoholic Fatty Liver DiseaseConceptsMetabolic functionsSpecies-specific interactionsKey metabolic functionsCell-autonomous mechanismsNon-alcoholic fatty liver diseaseMajor metabolic hubNon-parenchymal cellsMetabolic hubHuman hepatocytesMicroenvironmental regulationHuman diseasesHuman-specific aspectsHuman pathologiesHomeostatic processesSpecies mismatchCholesterol uptakeFatty liver diseaseParacrine mannerHuman immuneBile acid conjugationSinusoidal endothelial cellsHepatic metabolic functionMouse liverEndothelial cellsCells
2000
The liver as a site of T‐cell apoptosis: graveyard, or killing field?
Crispe I, Dao T, Klugewitz K, Mehal W, Metz D. The liver as a site of T‐cell apoptosis: graveyard, or killing field? Immunological Reviews 2000, 174: 47-62. PMID: 10807506, DOI: 10.1034/j.1600-0528.2002.017412.x.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAntigensApoptosisCD8-Positive T-LymphocytesCell AdhesionEndothelium, VascularFas ReceptorHepatitis CHumansImmune ToleranceImmunophenotypingIntestinal AbsorptionKiller Cells, NaturalKupffer CellsLiverLiver CirculationLiver TransplantationLymphocyte ActivationLymphocyte SubsetsMiceMice, TransgenicModels, ImmunologicalPortal VeinConceptsT cellsNatural killerT cell trappingNK T cellsPeripheral immune responsePortal vein infusionApoptotic T cellsT cell apoptosisNormal mouse liverPhenomenon of toleranceApoptotic CD8Liver allograftsOral toleranceHepatitis C.Lymphocyte populationsAntigenic cellsImmune responseLiver pathogensVein infusionClearance phaseLiver resultsLiverDirect perfusionMouse liverCell populations
1999
Selective retention of activated CD8+ T cells by the normal liver.
Mehal W, Juedes A, Crispe I. Selective retention of activated CD8+ T cells by the normal liver. The Journal Of Immunology 1999, 163: 3202-10. PMID: 10477588, DOI: 10.4049/jimmunol.163.6.3202.Peer-Reviewed Original Research