Novel aspects of glutamine synthetase in ammonia homeostasis
Zhou Y, Eid T, Hassel B, Danbolt NC. Novel aspects of glutamine synthetase in ammonia homeostasis. Neurochemistry International 2020, 140: 104809. PMID: 32758585, DOI: 10.1016/j.neuint.2020.104809.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidSevere liver diseaseElevated blood ammoniaAmmonia homeostasisInhibitory neurotransmitters glutamateUrea cycleEffects of hyperammonemiaPotassium bufferingNeurological sequelaeBrain edemaLiver diseaseBrain pathophysiologyUrea cycle pathwayBlood ammoniaExtrahepatic tissuesNeurotransmitter glutamateAmmonia clearanceAminobutyric acidComplete urea cycleCycle pathwayTwo-thirdsGlutamine synthetaseRecent studiesHomeostasisBody ammoniaCircadian-Like Rhythmicity of Extracellular Brain Glutamate in Epilepsy
Sandhu MRS, Dhaher R, Gruenbaum SE, Raaisa R, Spencer DD, Pavlova MK, Zaveri HP, Eid T. Circadian-Like Rhythmicity of Extracellular Brain Glutamate in Epilepsy. Frontiers In Neurology 2020, 11: 398. PMID: 32499751, PMCID: PMC7242976, DOI: 10.3389/fneur.2020.00398.Peer-Reviewed Original ResearchMesial temporal lobe epilepsyExtracellular brain glutamateSeizure onset regionTemporal lobe epilepsyType of epilepsyExcitatory neurotransmitter glutamateSeizure onset areaTranslational rodent modelEpileptogenic hippocampusLobe epilepsyIntracerebral microdialysisExtracellular glutamateBrain glutamateIndividual patientsRodent modelsControl animalsNeurotransmitter glutamateExtracellular levelsEpilepsySeizuresOnset areaCircadian-like rhythmGlutamateEssential modulatorPatients