2015
Tourette Syndrome: Bridging the Gap between Genetics and Biology
Richer P, Fernandez TV. Tourette Syndrome: Bridging the Gap between Genetics and Biology. Complex Psychiatry 2015, 1: 156-164. PMID: 26509143, PMCID: PMC4617782, DOI: 10.1159/000439085.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGenetic studiesNeuropsychiatric disordersGenetic complexityInvolvement of dopaminergicPrecise therapeutic targetsChildhood neuropsychiatric disordersAttention deficit hyperactivity disorderGenetic overlapGenetic alterationsBiologyDeficit hyperactivity disorderHistaminergic pathwayObsessive-compulsive disorderHigh comorbidityVocal ticsCurrent treatmentTherapeutic targetTourette syndromePhenotypeHyperactivity disorderImproved treatmentDisordersDiseaseTreatmentGenetics
2014
The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette syndrome: objectives and methods
Dietrich A, Fernandez TV, King RA, State MW, Tischfield JA, Hoekstra PJ, Heiman GA, the TIC Genetics Collaborative Group. The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette syndrome: objectives and methods. European Child & Adolescent Psychiatry 2014, 24: 141-151. PMID: 24771252, PMCID: PMC4209328, DOI: 10.1007/s00787-014-0543-x.Peer-Reviewed Original ResearchConceptsGenetic studiesSimilar genetic architectureGene discovery effortsMultiply affected pedigreesSingle major geneParent-child triosGenetic architectureMultigenic inheritanceDe novo mutationsMajor geneGenomic researchCollaborative Genetics StudyAffected pedigreesDiscovery effortsGenetic variantsGenetic contributionGenetics ConsortiumNovo mutationsGenesRare variantsBroader scientific communityGenetic riskRecent progressGeneticsVariants
2013
Genetic Susceptibility in Tourette Syndrome
Fernandez T, State M. Genetic Susceptibility in Tourette Syndrome. 2013, 137-155. DOI: 10.1093/med/9780199796267.003.0007.ChaptersRare copy number variantsCopy number variantsAssociation studiesGenome-wide association studiesGenome-wide detectionNumber variantsCommon complex traitsCandidate gene association studiesHuman genetic studiesComplex genetic contributionsRare variant studiesEtiology of TSCausative genetic lociGene association studiesComplex traitsNonparametric linkage analysisGene mappingDeleterious mutationsEarlier segregation analysisGenetic lociHDC genePathway analysisTS familyGenetic studiesLinkage analysis
2012
Genetics of Tourette syndrome and related disorders
Motlagh M, Fernandez T, Leckman J. Genetics of Tourette syndrome and related disorders. 2012, 336-346. DOI: 10.1017/cbo9781139025997.029.ChaptersPsychiatric geneticsGenome-wide association studiesGene expression studiesPsychiatric genetic studiesSpecific genesExpression studiesAssociation studiesGenetic studiesGenetic databasesGeneticsGenetic epidemiologyWorldwide distributionVaried rolesBrain developmentGenetic influencesEpigeneticsDevelopmental disordersGenesAlzheimer's diseaseDysregulationFamilyRelated disorders