2017
Menthol disrupts nicotine’s psychostimulant properties in an age and sex-dependent manner in C57BL/6J mice
Fait BW, Thompson DC, Mose TN, Jatlow P, Jordt SE, Picciotto MR, Mineur YS. Menthol disrupts nicotine’s psychostimulant properties in an age and sex-dependent manner in C57BL/6J mice. Behavioural Brain Research 2017, 334: 72-77. PMID: 28743602, PMCID: PMC5580257, DOI: 10.1016/j.bbr.2017.07.027.Peer-Reviewed Original ResearchConceptsAdult male miceNicotine intakeMale micePsychostimulant effectsPsychostimulant propertiesHome cage locomotor activitySex-dependent mannerSex-dependent mechanismsBlood levelsAdolescent miceFemale miceLocomotor stimulationLocomotor activityNicotine sensitivityAge groupsE-cigarettesMiceIntakeSignificant decreaseNicotineAgeSexBehavioral changesAdultsSpecific mechanismsTransient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti‐inflammatory effects of eucalyptol
Caceres AI, Liu B, Jabba SV, Achanta S, Morris JB, Jordt S. Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti‐inflammatory effects of eucalyptol. British Journal Of Pharmacology 2017, 174: 867-879. PMID: 28240768, PMCID: PMC5387001, DOI: 10.1111/bph.13760.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Infective AgentsAnti-Inflammatory AgentsCyclohexanolsDose-Response Relationship, DrugEdemaEucalyptolFemaleHEK293 CellsHumansInflammationInflammation MediatorsMaleMiceMice, Inbred C57BLMice, KnockoutMonoterpenesRandom AllocationTransient Receptor Potential ChannelsTRPM Cation ChannelsConceptsAnti-inflammatory effectsComplete Freund's adjuvantTRPM8 channelsPulmonary inflammationLeukocyte infiltrationNovel anti-inflammatory agentsInflammatory pain responsesSelective TRPM8 agonistsAdministration of LPSAnti-inflammatory propertiesChannel-deficient miceAnti-inflammatory agentsEffect of eucalyptolProduction of TNFTRP cation channelsMechanical allodyniaChemokine levelsTRPM8 agonistMyeloperoxidase activityFootpad inflammationFreund's adjuvantPain responseIL-1βIL-6Inflammatory cytokines
2013
TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis
Liu B, Escalera J, Balakrishna S, Fan L, Caceres A, Robinson E, Sui A, McKay M, McAlexander M, Herrick C, Jordt S. TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis. The FASEB Journal 2013, 27: 3549-3563. PMID: 23722916, PMCID: PMC3752543, DOI: 10.1096/fj.13-229948.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisSubstance PScratching behaviorContact dermatitisSensory neuronsSP receptor antagonistTRPA1-deficient miceCommon skin diseaseChronic inflammatory responseTransient receptor potential (TRP) ion channelsNerve growth factorPotential ion channelsEndogenous pruritogensPruritic responsesPersistent pruritusCutaneous inflammationLeukocyte infiltrationInflammatory cytokinesSkin edemaReceptor antagonistAllergic responsesContact allergensInflammatory responseKeratinocyte hyperplasiaSP signaling
2011
Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants
Willis DN, Liu B, Ha MA, Jordt S, Morris JB. Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. The FASEB Journal 2011, 25: 4434-4444. PMID: 21903934, PMCID: PMC3236628, DOI: 10.1096/fj.11-188383.Peer-Reviewed Original ResearchConceptsTransient receptor potential ankyrin 1Irritation responseMenthol effectsCold-sensitive sensory neuronsSensory TRP channelsSmoking-related morbiditySensory irritation responseEffect of mentholTransient receptor potential melastatin 8 (TRPM8) ion channelActivation of TRPM8TRPM8 agonistTRPM8 antagonistsCapsaicin receptorRespiratory tractSensory neuronsAnkyrin 1Pharmacological actionsNicotine addictionSmoking behaviorRespiratory irritationTRP channelsAgonistsSmoke constituentsAvailable cigarettesCigarettes
2010
Role of Metabolic Activation and the TRPA1 Receptor in the Sensory Irritation Response to Styrene and Naphthalene
Lanosa M, Willis D, Jordt S, Morris J. Role of Metabolic Activation and the TRPA1 Receptor in the Sensory Irritation Response to Styrene and Naphthalene. Toxicological Sciences 2010, 115: 589-595. PMID: 20176620, PMCID: PMC2948824, DOI: 10.1093/toxsci/kfq057.Peer-Reviewed Original ResearchConceptsSensory irritation responseIrritation responseTransient receptor potential ankyrin 1 receptorMetabolic activationFemale C57BL/6J miceCytochrome P450 activationTRPA1 receptorsC57BL/6J miceCYP450 metabolitesPlethysmographic measurementsPpm styreneSensory irritationInhibitor metyraponeP450 activationPpm naphthaleneReceptorsMiceActivationCurrent studyCritical roleResponseMetyraponeIrritationRole
2007
The menthol receptor TRPM8 is the principal detector of environmental cold
Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 2007, 448: 204-208. PMID: 17538622, DOI: 10.1038/nature05910.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCold TemperatureFemaleGanglia, SensoryGene TargetingMaleMentholMiceMice, Inbred C57BLThermosensingTRPM Cation ChannelsConceptsMenthol receptor TRPM8TRPM8 knockout miceIntact nerve fibersDifferent ion channelsNerve fibersWhole animal testsKnockout miceNoxious coldCold stimuliCold sensationCold transducerInnocuous coolEnvironmental coldTRPM8MiceIon channelsAnimal testsCellular levelPhysiological importanceCold sensitivity