2023
The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus
Robert S, Reeves B, Kiziltug E, Duy P, Karimy J, Mansuri M, Marlier A, Allington G, Greenberg A, DeSpenza T, Singh A, Zeng X, Mekbib K, Kundishora A, Nelson-Williams C, Hao L, Zhang J, Lam T, Wilson R, Butler W, Diluna M, Feinberg P, Schafer D, Movahedi K, Tannenbaum A, Koundal S, Chen X, Benveniste H, Limbrick D, Schiff S, Carter B, Gunel M, Simard J, Lifton R, Alper S, Delpire E, Kahle K. The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus. Cell 2023, 186: 764-785.e21. PMID: 36803604, PMCID: PMC10069664, DOI: 10.1016/j.cell.2023.01.017.Peer-Reviewed Original ResearchConceptsPost-infectious hydrocephalusTLR4-dependent immune responseBlood-cerebrospinal fluid barrierSmall molecule pharmacotherapyCell cross talkPharmacological immunomodulationCytokine stormNeuroimmune disordersBrain infectionDrug treatmentImmune responseAcquired hydrocephalusHydrocephalus modelChoroid plexusFluid barrierHydrocephalusEpithelial cellsCSFMulti-omics investigationsCross talkHypersecretionHemorrhagePharmacotherapyImmunomodulationPlexus
2022
Choroid plexus tissue perfusion and blood to CSF barrier function in rats measured with continuous arterial spin labeling
Lee H, Ozturk B, Stringer MS, Koundal S, MacIntosh BJ, Rothman D, Benveniste H. Choroid plexus tissue perfusion and blood to CSF barrier function in rats measured with continuous arterial spin labeling. NeuroImage 2022, 261: 119512. PMID: 35882269, PMCID: PMC9969358, DOI: 10.1016/j.neuroimage.2022.119512.Peer-Reviewed Original ResearchConceptsWater flowBlood perfusionLow-dose isofluraneCerebral blood flowClinical translational studiesAnti-diuretic hormoneContinuous arterial spinLevels of bloodMeasurement accuracyMagnetic resonance imagingArterial spin labelingCerebrospinal fluid productionAnesthetic regimensBalanced anesthesiaCerebral ventricleContinuous arterial spin labelingIsoflurane anesthesiaKey parametersSystemic administrationVentricular CSFImmune surveillanceArterial bloodBlood flowTissue perfusionChoroid plexus