2002
Biological significance of insulin-like growth factor binding proteins
Weinzimer S, Cohen P. Biological significance of insulin-like growth factor binding proteins. NeuroImmune Biology 2002, 2: 37-65. DOI: 10.1016/s1567-7443(02)80007-2.Peer-Reviewed Original ResearchInsulin-like growth factorGrowth factorFree insulin-like growth factorIGF/IGFBP axisCleavage of IGFBPsIGF-dependent actionsIGF-independent actionsPotent mitogenic agentsIGFBP axisIGFBP proteasesIGF receptorInflammatory diseasesIGFBPsGrowth disordersMitogenic agentsCellular proliferationCell growthSomatic growthHigh affinityPathophysiologyCancerProteinFactorsDiseaseBiological significance
2001
Transferrin Is an Insulin-Like Growth Factor-Binding Protein-3 Binding Protein1
Weinzimer S, Gibson T, Collett-Solberg P, Khare A, Liu B, Cohen P. Transferrin Is an Insulin-Like Growth Factor-Binding Protein-3 Binding Protein1. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 1806-1813. PMID: 11297622, DOI: 10.1210/jcem.86.4.7380.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsApoptosisCarrier ProteinsCell DivisionCells, CulturedDose-Response Relationship, DrugFluorescent Antibody TechniqueHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Binding ProteinsIronKineticsMaleMicroscopy, ConfocalMuscle, SmoothProstatic NeoplasmsSheepTissue DistributionTransferrinUrinary BladderYeastsConceptsIGFBP-3IGFBP-3-induced apoptosisInsulin-like growth factorBladder smooth muscle cellsHuman liver complementary DNA libraryProstate cancer cellsSmooth muscle cellsImportant physiological effectsIGF actionBinding proteinProteins/receptorsMuscle cellsProtein 3Growth factorCancer cellsCell proliferationTF treatmentPhysiological effectsNegligible affinityHuman serumTransferrin Is an Insulin-Like Growth Factor-Binding Protein-3 Binding Protein
Weinzimer SA. Transferrin Is an Insulin-Like Growth Factor-Binding Protein-3 Binding Protein. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 1806-1813. DOI: 10.1210/jc.86.4.1806.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsApoptosisCarrier ProteinsCell DivisionCells, CulturedDose-Response Relationship, DrugFluorescent Antibody TechniqueHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Binding ProteinsIronKineticsMaleMicroscopy, ConfocalMuscle, SmoothProstatic NeoplasmsSheepTissue DistributionTransferrinUrinary BladderYeastsConceptsIGFBP-3IGFBP-3-induced apoptosisInsulin-like growth factorBladder smooth muscle cellsHuman liver complementary DNA libraryProstate cancer cellsSmooth muscle cellsImportant physiological effectsIGF actionBinding proteinProteins/receptorsMuscle cellsProtein 3Growth factorCancer cellsCell proliferationTF treatmentPhysiological effectsNegligible affinityHuman serum
1999
Serum IGF‐I and IGFBP‐3 concentrations do not accurately predict growth hormone deficiency in children with brain tumours
Weinzimer S, Homan S, Ferry R, Moshang T. Serum IGF‐I and IGFBP‐3 concentrations do not accurately predict growth hormone deficiency in children with brain tumours. Clinical Endocrinology 1999, 51: 339-345. PMID: 10469014, DOI: 10.1046/j.1365-2265.1999.00804.x.Peer-Reviewed Original ResearchConceptsIGF-binding protein-3Hypothalamic/chiasmatic gliomaIGFBP-3 levelsGrowth hormone deficiencyBody mass indexPrimitive neuroectodermal tumorHypothalamic-chiasmatic gliomaProvocative GH testingIGFBP-3 concentrationsIGF-I levelsGH deficiencyGH testingHormone deficiencySerum IGFBrain tumorsPubertal stageTumor typesLower IGFBP-3 levelsNormal IGF-1 levelsLow IGF-I levelsGrowth factor insulin-like growth factorInsulin-like growth factorIGF-1 levelsRetrospective case reviewBone age delayCellular Actions of Insulin-Like Growth Factor Binding Proteins
Ferry R, Katz L, Grimberg A, Cohen P, Weinzimer S. Cellular Actions of Insulin-Like Growth Factor Binding Proteins. Hormone And Metabolic Research 1999, 31: 192-202. PMID: 10226802, PMCID: PMC4151550, DOI: 10.1055/s-2007-978719.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorFree insulin-like growth factorInsulin-like growth factor binding proteinGrowth factorCleavage of IGFBPsIGF-dependent actionsGrowth factor binding proteinFactor binding proteinPotent mitogenic agentsIGFBP proteasesIGF axisIGF receptorIGFBPsCellular actionsMitogenic agentsModulate levelsCellular proliferationCell growthBinding proteinSomatic growthHigh affinityProteinReceptors