2009
Phenotypic Integration Among Trabecular and Cortical Bone Traits Establishes Mechanical Functionality of Inbred Mouse Vertebrae*
Tommasini SM, Hu B, Nadeau JH, Jepsen KJ. Phenotypic Integration Among Trabecular and Cortical Bone Traits Establishes Mechanical Functionality of Inbred Mouse Vertebrae*. Journal Of Bone And Mineral Research 2009, 24: 606-620. PMID: 19063678, PMCID: PMC2659510, DOI: 10.1359/jbmr.081224.Peer-Reviewed Original ResearchConceptsQuantitative trait lociBody sizeBone traitsPhenotypic integrationTrait covariationComplex traitsTrait lociMultiple traitsGenetic analysisDifferent traitsEnvironmental perturbationsSkeletal traitsTrabecular traitsAXB/BXAC57BL/6J genomeRI panelNonrandom setTraitsCompensatory interactionsGenetic variantsAdaptive responseB6 genomeRelative amountsGenomeCompositional traits
2005
Genetic Variation in Structure‐Function Relationships for the Inbred Mouse Lumbar Vertebral Body*
Tommasini SM, Morgan TG, van der Meulen MCh, Jepsen KJ. Genetic Variation in Structure‐Function Relationships for the Inbred Mouse Lumbar Vertebral Body*. Journal Of Bone And Mineral Research 2005, 20: 817-827. PMID: 15824855, DOI: 10.1359/jbmr.041234.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsBiomechanical PhenomenaBone and BonesFemaleGenetic VariationLumbar VertebraeMiceMice, Inbred C3HMice, Inbred C57BLMice, Inbred StrainsModels, AnatomicModels, BiologicalModels, GeneticMultivariate AnalysisPhenotypeSpecies SpecificityStress, MechanicalStructure-Activity RelationshipTensile StrengthTomography, X-Ray ComputedConceptsMechanical propertiesBone mechanical propertiesTrabecular bone tissueWhole bone mechanical propertiesMeasure of ductilityTotal deformationFailure loadVertebral mechanical propertiesBone tissueIsotropic voxel sizeBiomechanical analysisImaging systemPropertiesDuctilityStructure-function relationshipsVoxel sizeDeformationBV/TVStiffness