2018
A Brain–Heart Biomarker for Epileptogenesis
Bahari F, Ssentongo P, Schiff S, Gluckman B. A Brain–Heart Biomarker for Epileptogenesis. Journal Of Neuroscience 2018, 38: 8473-8483. PMID: 30150365, PMCID: PMC6158692, DOI: 10.1523/jneurosci.1130-18.2018.Peer-Reviewed Original ResearchConceptsBrain-heart interactionsBiomarkers of epileptogenesisDevelopment of epilepsyAutonomic cardiac activityIdentification of patientsPostinjury epilepsyPreventable sequelaeFirst seizureBrain insultsCortical dischargesMale miceEpileptogenesisMurine modelMouse modelCardiac rhythmReliable biomarkersEpilepsyChronic measurementTreatment developmentBiomarkersSuch treatmentCardiac activityTherapeutic purposesBrain activityPatients
2017
A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection
Ssentongo P, Robuccio A, Thuku G, Sim D, Nabi A, Bahari F, Shanmugasundaram B, Billard M, Geronimo A, Short K, Drew P, Baccon J, Weinstein S, Gilliam F, Stoute J, Chinchilli V, Read A, Gluckman B, Schiff S. A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection. Scientific Reports 2017, 7: 43652. PMID: 28272506, PMCID: PMC5341121, DOI: 10.1038/srep43652.Peer-Reviewed Original ResearchConceptsCerebral malariaAnimal modelsStrain combinationsPrevention of epilepsySuch animal modelsSubsequent epilepsyNeurological sequelaeAdjunctive therapyPathophysiological mechanismsMalaria infectionUnexpected deathMurine modelEpilepsyPreclinical researchSUDEPMalariaGenetic backgroundMultiple miceEpileptogenesisSequelaeTherapyInfectionMiceSurvivorsPrevention
2015
Role of Multiple-Scale Modeling of Epilepsy in Seizure Forecasting
Kuhlmann L, Grayden D, Wendling F, Schiff S. Role of Multiple-Scale Modeling of Epilepsy in Seizure Forecasting. Journal Of Clinical Neurophysiology 2015, 32: 220-226. PMID: 26035674, PMCID: PMC4455036, DOI: 10.1097/wnp.0000000000000149.Peer-Reviewed Original Research
2013
Synchronization and desynchronization in epilepsy: controversies and hypotheses
Jiruska P, de Curtis M, Jefferys J, Schevon C, Schiff S, Schindler K. Synchronization and desynchronization in epilepsy: controversies and hypotheses. The Journal Of Physiology 2013, 591: 787-797. PMID: 23184516, PMCID: PMC3591697, DOI: 10.1113/jphysiol.2012.239590.Peer-Reviewed Original ResearchConceptsNeuronal firingPathophysiology of epilepsyFunctional brain disordersEnd of seizureEpileptiform phenomenaLocal field potentialsLarge neuronal populationsNeuronal populationsNon-firing neuronsBrain disordersSeizuresSpecific inhibitoryEpilepsyExcitatory interactionsNeuronal networksRecent evidenceField potentialsHypersynchronous statesExcessive synchronizationFiring
2010
Controversies in epilepsy: Debates held during the Fourth International Workshop on Seizure Prediction
Frei MG, Zaveri HP, Arthurs S, Bergey GK, Jouny CC, Lehnertz K, Gotman J, Osorio I, Netoff TI, Freeman WJ, Jefferys J, Worrell G, Le Van Quyen M, Schiff SJ, Mormann F. Controversies in epilepsy: Debates held during the Fourth International Workshop on Seizure Prediction. Epilepsy & Behavior 2010, 19: 4-16. PMID: 20708976, PMCID: PMC2943379, DOI: 10.1016/j.yebeh.2010.06.009.Peer-Reviewed Original Research
2009
Advances in the Application of Technology to Epilepsy: The CIMIT/NIO Epilepsy Innovation Summit
Schachter S, Guttag J, Schiff S, Schomer D, Contributors S. Advances in the Application of Technology to Epilepsy: The CIMIT/NIO Epilepsy Innovation Summit. Epilepsy & Behavior 2009, 16: 3-46. PMID: 19780225, PMCID: PMC8118381, DOI: 10.1016/j.yebeh.2009.06.028.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnticonvulsantsBrain MappingChildDrug ResistanceElectric Stimulation TherapyElectroencephalographyEngineeringEpilepsyHumansMagnetic Resonance ImagingMedical Laboratory ScienceMicroelectrodesNanoparticlesNeuronsNeurosurgeryNeurotoxinsPredictive Value of TestsSeizuresSpectroscopy, Near-InfraredTomography, Emission-Computed, Single-PhotonTomography, OpticalTranscranial Magnetic StimulationConceptsTreatment systemEvaluation of patientsTreatment of patientsGroup of cliniciansEpilepsy surgeryEngineering technologyFurther technological developmentEpilepsySeizure onset detectionPatientsEngineersSeizure predictionTechnologyApplicationsOnset detectionSurgeryCliniciansPhysiciansUnmetDiagnosisSeizure entrainment with polarizing low-frequency electric fields in a chronic animal epilepsy model
Sunderam S, Chernyy N, Peixoto N, Mason J, Weinstein S, Schiff S, Gluckman B. Seizure entrainment with polarizing low-frequency electric fields in a chronic animal epilepsy model. Journal Of Neural Engineering 2009, 6: 046009. PMID: 19602730, PMCID: PMC3057918, DOI: 10.1088/1741-2560/6/4/046009.Peer-Reviewed Original ResearchConceptsField postsynaptic potentialsAnimal epilepsy modelsNeural activitySimultaneous recordingSpontaneous seizuresHippocampal epilepsyVentral hippocampusEpilepsy modelLocal field potentialsPostsynaptic potentialsNeuronal excitabilityNeuronal activityModulatory effectsAnimal modelsSeizuresStatistical significanceStimulationField potentialsMultiple presentationsAnimalsCharacteristic patternEpilepsyHippocampusRecordingsExcitability
2008
Multi-taper transfer function estimation for stimulation artifact removal from neural recordings
Chernyy N, Schiff S, Gluckman B. Multi-taper transfer function estimation for stimulation artifact removal from neural recordings. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2008, 2008: 2772-2776. PMID: 19163280, PMCID: PMC3547985, DOI: 10.1109/iembs.2008.4649777.Peer-Reviewed Original Research
2003
In Vivo Modulation of Hippocampal Epileptiform Activity with Radial Electric Fields
Richardson K, Gluckman B, Weinstein S, Glosch C, Moon J, Gwinn R, Gale K, Schiff S. In Vivo Modulation of Hippocampal Epileptiform Activity with Radial Electric Fields. Epilepsia 2003, 44: 768-777. PMID: 12790889, DOI: 10.1046/j.1528-1157.2003.35402.x.Peer-Reviewed Original ResearchMeSH KeywordsAmplifiers, ElectronicAnimalsDisease Models, AnimalElectric StimulationElectric Stimulation TherapyElectrodes, ImplantedElectronics, MedicalEpilepsyHippocampusHumansKainic AcidKindling, NeurologicMaleMembrane PotentialsMicroelectrodesRatsRats, Sprague-DawleySeizuresStereotaxic TechniquesConceptsElectric field modulationRadial electric fieldElectric fieldElectric field controlField modulationMicroelectrode pairsCharge deliveryControl systemElectrode geometryField controlSeizure onset detectionElectrodeElectric field stimulationElectronicsStimulation electrodesFieldFirst resultsNovel approachExperiments
2001
Early Seizure Detection
Jerger K, Netoff T, Francis J, Sauer T, Pecora L, Weinstein S, Schiff S. Early Seizure Detection. Journal Of Clinical Neurophysiology 2001, 18: 259-268. PMID: 11528297, DOI: 10.1097/00004691-200105000-00005.Peer-Reviewed Original ResearchAdaptive Electric Field Control of Epileptic Seizures
Gluckman B, Nguyen H, Weinstein S, Schiff S. Adaptive Electric Field Control of Epileptic Seizures. Journal Of Neuroscience 2001, 21: 590-600. PMID: 11160438, PMCID: PMC6763796, DOI: 10.1523/jneurosci.21-02-00590.2001.Peer-Reviewed Original Research
2000
Brain chirps: spectrographic signatures of epileptic seizures
Schiff S, Colella D, Jacyna G, Hughes E, Creekmore J, Marshall A, Bozek-Kuzmicki M, Benke G, Gaillard W, Conry J, Weinstein S. Brain chirps: spectrographic signatures of epileptic seizures. Clinical Neurophysiology 2000, 111: 953-958. PMID: 10825700, DOI: 10.1016/s1388-2457(00)00259-5.Peer-Reviewed Original Research
1998
Forecasting brain storms
Schiff S. Forecasting brain storms. Nature Medicine 1998, 4: 1117-1118. PMID: 9771736, DOI: 10.1038/2610.Peer-Reviewed Original ResearchPeriodic Orbits: A New Language for Neuronal Dynamics
So P, Francis J, Netoff T, Gluckman B, Schiff S. Periodic Orbits: A New Language for Neuronal Dynamics. Biophysical Journal 1998, 74: 2776-2785. PMID: 9635732, PMCID: PMC1299619, DOI: 10.1016/s0006-3495(98)77985-8.Peer-Reviewed Original Research
1996
Electric field suppression of epileptiform activity in hippocampal slices
Gluckman B, Neel E, Netoff T, Ditto W, Spano M, Schiff S. Electric field suppression of epileptiform activity in hippocampal slices. Journal Of Neurophysiology 1996, 76: 4202-4205. PMID: 8985916, DOI: 10.1152/jn.1996.76.6.4202.Peer-Reviewed Original Research
1995
Periodic pacing an in vitro epileptic focus
Jerger K, Schiff S. Periodic pacing an in vitro epileptic focus. Journal Of Neurophysiology 1995, 73: 876-879. PMID: 7760143, DOI: 10.1152/jn.1995.73.2.876.Peer-Reviewed Original Research
1994
Fast wavelet transformation of EEG
Schiff S, Aldroubi A, Unser M, Sato S. Fast wavelet transformation of EEG. Clinical Neurophysiology 1994, 91: 442-455. PMID: 7529683, DOI: 10.1016/0013-4694(94)90165-1.Peer-Reviewed Original ResearchConceptsFeature extractionWavelet transformOrdinary microprocessorsComputational demandsRedundant samplingComputational timeMultiresolution frameworkData window lengthReal timeWavelet transformationContinuous wavelet transformRapid algorithmWaveletsAnalysis of EEGExtractionWindow lengthBackground noiseTransformAlgorithmPolynomial splinesMicroprocessorFourier transform techniqueRecent workCertain advantagesNumerical techniques