2022
Improving Infant Hydrocephalus Outcomes in Uganda: A Longitudinal Prospective Study Protocol for Predicting Developmental Outcomes and Identifying Patients at Risk for Early Treatment Failure after ETV/CPC
Vadset T, Rajaram A, Hsiao C, Katungi M, Magombe J, Seruwu M, Nsubuga B, Vyas R, Tatz J, Playter K, Nalule E, Natukwatsa D, Wabukoma M, Perez L, Mulondo R, Queally J, Fenster A, Kulkarni A, Schiff S, Grant P, Kabachelor E, Warf B, Sutin J, Lin P. Improving Infant Hydrocephalus Outcomes in Uganda: A Longitudinal Prospective Study Protocol for Predicting Developmental Outcomes and Identifying Patients at Risk for Early Treatment Failure after ETV/CPC. Metabolites 2022, 12: 78. PMID: 35050201, PMCID: PMC8781620, DOI: 10.3390/metabo12010078.Peer-Reviewed Original ResearchCerebral blood flowTreatment failureETV/CPCEarly treatment failureProspective study protocolCerebral tissue oxygenationProgression of hydrocephalusVentriculoperitoneal shunt placementLong-term outcomesEvidence-based guidelinesPost-operative careEndoscopic third ventriculostomyCerebral metabolic rateMulti-center trialChoroid plexus cauterizationGlobal health burdenCURE Children's HospitalYears of agePost-operative measurementsHydrocephalus outcomesNeurodevelopmental outcomesSurgical treatmentNeurodevelopmental assessmentShunt placementChildren's Hospital
2017
Endoscopic Treatment versus Shunting for Infant Hydrocephalus in Uganda
Kulkarni A, Schiff S, Mbabazi-Kabachelor E, Mugamba J, Ssenyonga P, Donnelly R, Levenbach J, Monga V, Peterson M, MacDonald M, Cherukuri V, Warf B. Endoscopic Treatment versus Shunting for Infant Hydrocephalus in Uganda. New England Journal Of Medicine 2017, 377: 2456-2464. PMID: 29262276, PMCID: PMC5784827, DOI: 10.1056/nejmoa1707568.Peer-Reviewed Original ResearchConceptsETV-CPCPostinfectious hydrocephalusUgandan infantsTreatment failureCognitive outcomesBrain volumeSingle-center studyEndoscopic third ventriculostomyChoroid plexus cauterizationMajor health problemSignificant differencesLanguage scoresSecondary outcomesEndoscopic treatmentPrimary outcomeVentricular sizeThird ventriculostomyInfant hydrocephalusComputed tomographyTreatment groupsAlternative treatmentLate failureBayley ScalesBrain growthConventional treatment