1988
Reversible Synaptic Blockade Caused by Hypoxia of Moderate Degree in Hippocampal Tissues Slices
Schiff S, Somjen G. Reversible Synaptic Blockade Caused by Hypoxia of Moderate Degree in Hippocampal Tissues Slices. Advances In Behavioral Biology 1988, 35: 175-182. DOI: 10.1007/978-1-4684-5562-5_20.Peer-Reviewed Original ResearchArtificial cerebrospinal fluidHypoxic episodesIschemic brain infarctsModerate hypoxic episodesOrthodromic population spikesReversible synaptic blockadeExcitatory postsynaptic potentialsInterstitial potassium concentrationAfferent fiber volleysHippocampal tissue slicesImpairment of membraneTissue slicesPosthypoxic hyperexcitabilityBrain infarctsSynaptic blockadePopulation spikesReadmission of oxygenFiber volleyPostsynaptic potentialsCA1 regionPyramidal cellsRat hippocampusSynaptic transmissionCerebrospinal fluidCalcium levels
1987
The effect of graded hypoxia on the hippocampal slice: an in vitro model of the ischemic penumbra.
Schiff S, Somjen G. The effect of graded hypoxia on the hippocampal slice: an in vitro model of the ischemic penumbra. Stroke 1987, 18: 30-37. PMID: 3027927, DOI: 10.1161/01.str.18.1.30.Peer-Reviewed Original ResearchConceptsMild hypoxiaSynaptic transmissionModerate hypoxiaHippocampal slicesGrade of hypoxiaHypoxic brain tissueExtracellular DC potentialDegree of hypoxiaPosthypoxic hyperexcitabilityIschemic penumbraExtracellular calciumExtracellular potassiumSynaptic functionBrain tissueHypoxiaHyperexcitabilityExtracellular pHSlicesSevere depolarizationNeuronsDC potentialResponse