2022
Type IV Pili Are a Critical Virulence Factor in Clinical Isolates of Paenibacillus thiaminolyticus
Hehnly C, Shi A, Ssentongo P, Zhang L, Isaacs A, Morton S, Streck N, Erdmann-Gilmore P, Tolstoy I, Townsend R, Limbrick D, Paulson J, Ericson J, Galperin M, Schiff S, Broach J. Type IV Pili Are a Critical Virulence Factor in Clinical Isolates of Paenibacillus thiaminolyticus. MBio 2022, 13: e02688-22. PMID: 36374038, PMCID: PMC9765702, DOI: 10.1128/mbio.02688-22.Peer-Reviewed Original ResearchConceptsPostinfectious hydrocephalusClinical isolatesVirulence factorsCritical virulence factorPotential virulence factorsPoor long-term outcomesPrevention of hydrocephalusLong-term outcomesBacterial pathogensDevastating sequelaeNeonatal sepsisMiddle-income countriesNeonatal infectionSurgical interventionReference strainsNovel bacterial pathogensAfrican cohortBeta-lactamase genesChildhood mortalityHydrocephalusTherapeutic targetInfectionVirulent strainDevastating diseaseWhole-genome sequencing
2020
Association of Undernutrition and Neonatal, Infant and Under-5 Mortality: Evidence from 62 Low-Income and Middle-Income Countries
Ssentongo P, Lewcun J, Ssentongo A, Ba D, Fronterre C, Ericson J, Gernand A, Wang M, Du P, Chinchilli V, Schiff S. Association of Undernutrition and Neonatal, Infant and Under-5 Mortality: Evidence from 62 Low-Income and Middle-Income Countries. Current Developments In Nutrition 2020, 4: nzaa053_116. PMCID: PMC7258382, DOI: 10.1093/cdn/nzaa053_116.Peer-Reviewed Original ResearchNeonatal mortalityRelative riskMiddle-income countriesChild mortalityInfant mortalityRepresentative cross-sectional surveyAssociation of undernutritionMultivariate Poisson regression modelEarly childhood undernutritionCross-sectional surveyUnder-5 MortalityPoisson regression modelsMean durationLive birthsMortality incidenceMillennium Development Goals eraMortality rateResults OverallMDG 4Country-level prevalenceChildhood undernutritionInfantsMortalityBreastfeedingNational Institute