2024
Assessment of a screening tool to aid home-based identification of adolescents (aged 10–14) living with HIV in Zambia and South Africa: HPTN 071 (PopART) study
Chaila M, Mcleod D, Vermund S, Mbolongwe-Thornicroft M, Mbewe M, Mubekapi-Musadaidzwa C, Harper A, Schaap A, Floyd S, Hoddinott G, Hayes R, Fidler S, Ayles H, Shanaube K, Team O. Assessment of a screening tool to aid home-based identification of adolescents (aged 10–14) living with HIV in Zambia and South Africa: HPTN 071 (PopART) study. PLOS ONE 2024, 19: e0266573. PMID: 38363733, PMCID: PMC10871489, DOI: 10.1371/journal.pone.0266573.Peer-Reviewed Original ResearchConceptsScreening toolUniversal testingCommunity HIV-care providersCombination HIV prevention packageHIV-care providersHIV-positiveHIV prevention packageRapid HIV testingHIV test resultsRapid HIV test resultsHistory of hospital admissionIdentification of adolescentsPopART interventionUndiagnosed HIVHIV testingPrevention packageDoor-to-doorPoor healthHIV interventionsCommunity settingsConsented adolescentsHospital admissionSelf-reportSouth AfricaPopART
2023
Brief Report: How Do We Reach Men? Offering HIV Testing in Evenings and Weekends in the HPTN 071 (PopART) Community-Based Trial in South Africa
Yang B, Sloot R, Floyd S, Awoniyi D, Griffith S, Ayles H, Fidler S, Hayes R, Vermund S, Bock P, team H. Brief Report: How Do We Reach Men? Offering HIV Testing in Evenings and Weekends in the HPTN 071 (PopART) Community-Based Trial in South Africa. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2023, 93: 300-304. PMID: 37001128, PMCID: PMC10313787, DOI: 10.1097/qai.0000000000003197.Peer-Reviewed Original ResearchConceptsHIV testingHousehold visitsWeekday shiftsNumber of menCommunity HIV care providersCommunity-based HIV testingHIV care providersHPTN 071 (PopART) trialUnknown HIV statusHigh-burden settingsAntiretroviral treatment coverageCommunity-based trialHigh-risk behaviorsCommunity-based servicesPopART interventionHIV statusHIV epidemicTreatment coverageCare providersLinear regression analysisStudy questionnaireMore menRecruitment of menVisitsWomenCombination HIV prevention during pregnancy and the post‐partum period in Malawi and Zambia: a mathematical modelling analysis
Powers K, Mutale W, Rosenberg N, Graybill L, Mollan K, Freeborn K, Saidi F, Maman S, Mulenga P, Jahn A, Nyirenda R, Stringer J, Vermund S, H. B. Combination HIV prevention during pregnancy and the post‐partum period in Malawi and Zambia: a mathematical modelling analysis. Journal Of The International AIDS Society 2023, 26: e26128. PMID: 37403422, PMCID: PMC10320044, DOI: 10.1002/jia2.26128.Peer-Reviewed Original ResearchConceptsFemale HIV transmissionMaternal HIV acquisitionMaternal HIV incidenceHIV prevention strategiesPost-partum periodAntiretroviral therapyHIV transmissionMale partnersHIV acquisitionHIV incidenceANC patientsPrevention strategiesCombination HIV prevention strategiesCombination HIV prevention interventionSuppressive antiretroviral therapyPre-exposure prophylaxisVertical HIV transmissionAntenatal care programsCombination HIV preventionHIV prevention interventionsANC initiationART initiationUnsuppressed HIVIncident infectionsUndiagnosed HIV
2022
Projected outcomes of universal testing and treatment in a generalised HIV epidemic in Zambia and South Africa (the HPTN 071 [PopART] trial): a modelling study
Probert W, Sauter R, Pickles M, Cori A, Bell-Mandla N, Bwalya J, Abeler-Dörner L, Bock P, Donnell D, Floyd S, Macleod D, Piwowar-Manning E, Skalland T, Shanaube K, Wilson E, Yang B, Ayles H, Fidler S, Hayes R, Fraser C, Team H, Hayes R, Fidler S, Beyers N, Ayles H, Bock P, El-Sadr W, Cohen M, Eshleman S, Agyei Y, Piwowar-Manning E, Bond V, Hoddinott G, Donnell D, Floyd S, Wilson E, Emel L, Noble H, Macleod D, Burns D, Fraser C, Cori A, Sista N, Griffith S, Moore A, Headen T, White R, Miller E, Hargreaves J, Hauck K, Thomas R, Limbada M, Bwalya J, Pickles M, Sabapathy K, Schaap, Dunbar R, Shanaube K, Yang B, Simwinga M, Smith P, Vermund S, Mandla N, Makola N, van Deventer A, James A, Jennings K, Kruger J, Phiri M, Kosloff B, Mwenge L, Kanema S, Sauter R, Probert W, Kumar R, Sakala E, Silumesi A, Skalland T, Yuhas K. Projected outcomes of universal testing and treatment in a generalised HIV epidemic in Zambia and South Africa (the HPTN 071 [PopART] trial): a modelling study. The Lancet HIV 2022, 9: e771-e780. PMID: 36332654, PMCID: PMC9646978, DOI: 10.1016/s2352-3018(22)00259-4.Peer-Reviewed Original ResearchConceptsStandard of careHome-based testingCluster-randomised trialHigh-prevalence communitiesHIV incidenceHIV epidemicNational guidelinesNational InstituteUniversal testingHIV care cascadeAntiretroviral therapy uptakeUS President's Emergency PlanGeneralised HIV epidemicPresident's Emergency PlanPopART interventionCare cascadeART eligibilityArm BTherapy uptakeTrial interventionTrial dataInfectious diseasesAIDS ReliefIntervention impactDrug abuse
2021
Community-based health workers implementing universal access to HIV testing and treatment: lessons from South Africa and Zambia—HPTN 071 (PopART)
Viljoen L, Mainga T, Casper R, Mubekapi-Muzadaidzwa C, Wademan D, Bond V, Pliakas T, Bwalya C, Stangl A, Phiri M, Yang B, Shanaube K, Bock P, Fidler S, Hayes R, Ayles H, Hargreaves J, Hoddinott G, Seeley J, Donnell D, Floyd S, Mandla N, Bwalya J, Sabapathy K, Eshleman S, Macleod D, Moore A, Vermund S, Hauck K, Shanaube K. Community-based health workers implementing universal access to HIV testing and treatment: lessons from South Africa and Zambia—HPTN 071 (PopART). Health Policy And Planning 2021, 36: 881-890. PMID: 33963387, PMCID: PMC8227454, DOI: 10.1093/heapol/czab019.Peer-Reviewed Original ResearchConceptsCommunity-based health workersHIV testingHealth workersHIV prevention packageHPTN 071 (PopART) trialHIV epidemic controlPopulation health benefitsPopART interventionCHW interventionPrevention packageTreatment servicesIntervention staffTrial outcomesBaseline quantitative dataReferral servicesCHW retentionHealth benefitsIntervention packageProcess evaluationEpidemic controlGroup discussionsInterventionTrialsKey informant interviewsEmotional support
2020
Integrating and Interpreting Findings from the Latest Treatment as Prevention Trials
Brault MA, Spiegelman D, Abdool Karim SS, Vermund SH. Integrating and Interpreting Findings from the Latest Treatment as Prevention Trials. Current HIV/AIDS Reports 2020, 17: 249-258. PMID: 32297219, PMCID: PMC7260110, DOI: 10.1007/s11904-020-00492-4.Peer-Reviewed Original ResearchMeasuring child survival for the Millennium Development Goals in Africa: what have we learned and what more is needed to evaluate the Sustainable Development Goals?
Brault MA, Mwinga K, Kipp AM, Kennedy SB, Maimbolwa M, Moyo P, Ngure K, Haley CA, Vermund SH. Measuring child survival for the Millennium Development Goals in Africa: what have we learned and what more is needed to evaluate the Sustainable Development Goals? Global Health Action 2020, 13: 1732668. PMID: 32114967, PMCID: PMC7067162, DOI: 10.1080/16549716.2020.1732668.Peer-Reviewed Original ResearchConceptsSustainable Development Goal periodMillennium Development GoalsDevelopment GoalsGoal periodAreas of governanceMillennium Development Goal periodKey global health challengeSustainable Development GoalsChild mortalityCountry‐specific goalsQualitative data collectionPolicy documentsNational contextsRegion nationsCountries—KenyaQualitative interviewsSub-Saharan AfricaMethodological opportunitiesInternational goalsFamiliar themesValuable lessonsCountriesCase studyChild survivalQuantitative indicators
2019
Effect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART)
Hayes RJ, Donnell D, Floyd S, Mandla N, Bwalya J, Sabapathy K, Yang B, Phiri M, Schaap A, Eshleman SH, Piwowar-Manning E, Kosloff B, James A, Skalland T, Wilson E, Emel L, Macleod D, Dunbar R, Simwinga M, Makola N, Bond V, Hoddinott G, Moore A, Griffith S, Deshmane Sista N, Vermund SH, El-Sadr W, Burns DN, Hargreaves JR, Hauck K, Fraser C, Shanaube K, Bock P, Beyers N, Ayles H, Fidler S. Effect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART). New England Journal Of Medicine 2019, 381: 207-218. PMID: 31314965, PMCID: PMC6587177, DOI: 10.1056/nejmoa1814556.Peer-Reviewed Original ResearchConceptsHIV-positive participantsViral suppressionHIV infectionGroup BGroup AGroup CMonth 12Universal testingPrevention interventionsPopulation cohortHuman immunodeficiency virus (HIV) infectionHome-based HIV testingBaseline HIV prevalenceCombination prevention interventionsImmunodeficiency virus infectionHIV-positive adultsPopulation-level incidenceNew HIV infectionsAdjusted rate ratiosCommunity-randomized trialLack of effectHIV carePrevious trial resultsStandard careART adherence
2017
Differences in health-related quality of life between HIV-positive and HIV-negative people in Zambia and South Africa: a cross-sectional baseline survey of the HPTN 071 (PopART) trial
Thomas R, Burger R, Harper A, Kanema S, Mwenge L, Vanqa N, Bell-Mandla N, Smith P, Floyd S, Bock P, Ayles H, Beyers N, Donnell D, Fidler S, Hayes R, Hauck K, Team H, Hargreaves J, Watson-Jones D, Godfrey-Faussett P, Cori A, Pickles M, Mandla N, Yang B, James A, Vermaak R, Makola N, Hoddinott G, Naidoo V, Bond V, Simwinga M, Mwinga A, Kosloff B, Limbada M, Bwalya J, Ngulube C, Fraser C, Eshleman S, Agyei Y, Cummings V, Catalano D, Emel L, Bunts L, Noble H, Burns D, Kouda A, Sista N, Moore A, White R, Headen T, Miller E, Hinson K, Vermund S, Barnes M, Horn L, Mwango A, Baldwin M, Wolf S, Hughes E. Differences in health-related quality of life between HIV-positive and HIV-negative people in Zambia and South Africa: a cross-sectional baseline survey of the HPTN 071 (PopART) trial. The Lancet Global Health 2017, 5: e1133-e1141. PMID: 28964756, PMCID: PMC5640509, DOI: 10.1016/s2214-109x(17)30367-4.Peer-Reviewed Original ResearchConceptsHIV-negative peopleHIV-positive individualsHIV-negative individualsAntiretroviral therapyHealth-related qualityHIV careHRQoL scoresHIV statusHerpes simplex virus type-2 statusNational InstituteHPTN 071 (PopART) studyHPTN 071 (PopART) trialLaboratory-confirmed HIVType 2 statusCross-sectional baseline surveyLarge cross-sectional surveyRecreational drug useCross-sectional surveyPresident's Emergency PlanGeneral population sampleHRQoL informationBetter HRQoLHIV-negativeHIV progressionHRQoL dataStrengthening and expanding the capacity of health worker education in Zambia
Michelo C, Zulu JM, Simuyemba M, Andrews B, Katubulushi M, Chi B, Njelesani E, Vwalika B, Bowa K, Maimbolwa M, Chipeta J, Goma F, Nzala S, Banda S, Mudenda J, Ahmed Y, Hachambwa L, Wilson C, Vermund S, Mulla Y. Strengthening and expanding the capacity of health worker education in Zambia. Pan African Medical Journal 2017, 27: 92. PMID: 28819513, PMCID: PMC5554665, DOI: 10.11604/pamj.2017.27.92.6860.Peer-Reviewed Original ResearchConceptsMEPI programClinical skills laboratoryStaff development programsQuality of trainingNew postgraduate programHealth worker educationStudent enrollmentSpecialized curriculumSkills laboratoryMedical educationPostgraduate programsAcademic environmentInternational partnershipsWorker educationDevelopment programsDocumentary reviewThematic approachMoodleInitiative ProgramEducationFacultyNew partnershipsTraining processWork motivationProgram
2016
Improving access to child health services at the community level in Zambia: a country case study on progress in child survival, 2000–2013
Kipp AM, Maimbolwa M, Brault MA, Kalesha-Masumbu P, Katepa-Bwalya M, Habimana P, Vermund SH, Mwinga K, Haley CA. Improving access to child health services at the community level in Zambia: a country case study on progress in child survival, 2000–2013. Health Policy And Planning 2016, 32: 603-612. PMID: 28453711, PMCID: PMC5964895, DOI: 10.1093/heapol/czw141.Peer-Reviewed Original ResearchConceptsMNCH servicesCountry case studiesChild survivalMillennium Development GoalsCommunity health strategyOngoing reformsDevelopment GoalsKey informantsNational commitmentNational documentsHealth servicesMDG periodFinancing limitationsQualitative dataAfrican countriesCountry studiesNational Health Strategic PlansCommunity levelExternal partnersBasic transportationCommunity health workersChild health servicesUniversal accessFunding increasesCommunity women
2015
The Effect of Cryotherapy on Human Papillomavirus Clearance Among HIV-Positive Women in Lusaka, Zambia
Katundu K, Bateman AC, Pfaendler KS, Mwanahamuntu MH, Kapambwe S, Vermund SH, Sahasrabuddhe VV, Msadabwe SC, Stringer JS, Parham GP, Chibwesha CJ. The Effect of Cryotherapy on Human Papillomavirus Clearance Among HIV-Positive Women in Lusaka, Zambia. Journal Of Lower Genital Tract Disease 2015, 19: 301-306. PMID: 26125097, PMCID: PMC4583804, DOI: 10.1097/lgt.0000000000000131.Peer-Reviewed Original ResearchConceptsHIV-positive womenWeeks of treatmentHrHPV infectionHrHPV typesHigh-risk HPV cervical infectionHigh HIV burden settingsHIV burden settingsHPV cervical infectionHuman papillomavirus clearancePrevalence of hrHPVCommon HPV typesHuman papillomavirus infectionRoche Linear ArrayEffects of cryotherapyHPV vaccinationMedian CD4Antiretroviral therapyCervical infectionCohort studyPapillomavirus infectionBurden settingsCervical diseaseHPV typesMedian ageCervical screeningImplementation and Operational Research
Kapambwe S, Sahasrabuddhe VV, Blevins M, Mwanahamuntu MH, Mudenda V, Shepherd BE, Chibwesha CJ, Pfaendler KS, Hicks ML, Vermund SH, Stringer JS, Parham GP. Implementation and Operational Research. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2015, 70: e20-e26. PMID: 26322673, PMCID: PMC4791059, DOI: 10.1097/qai.0000000000000685.Peer-Reviewed Original ResearchConceptsUnknown HIV serostatusHIV serostatusYoung womenCervical cancerOlder womenHIV/AIDS care programsCervical cancer prevention programsInvasive cervical cancer casesRisk of ICCHIV-seronegative womenHIV-seropositive womenIndependent risk factorCancer prevention programsCervical cancer casesMultivariable logistic regressionAIDS care programsLifetime sexual partnersHIV infectionSaharan AfricaRisk factorsCancer casesAge 35High riskICC casesCare programPopulation-Level Scale-Up of Cervical Cancer Prevention Services in a Low-Resource Setting: Development, Implementation, and Evaluation of the Cervical Cancer Prevention Program in Zambia
Parham GP, Mwanahamuntu MH, Kapambwe S, Muwonge R, Bateman AC, Blevins M, Chibwesha CJ, Pfaendler KS, Mudenda V, Shibemba AL, Chisele S, Mkumba G, Vwalika B, Hicks ML, Vermund SH, H. BH, Stringer JS, Sankaranarayanan R, Sahasrabuddhe VV. Population-Level Scale-Up of Cervical Cancer Prevention Services in a Low-Resource Setting: Development, Implementation, and Evaluation of the Cervical Cancer Prevention Program in Zambia. PLOS ONE 2015, 10: e0122169. PMID: 25885821, PMCID: PMC4401717, DOI: 10.1371/journal.pone.0122169.Peer-Reviewed Original ResearchConceptsCervical cancer prevention programsCancer prevention programsHistopathologic evaluationCervical intraepithelial neoplasia grade 2Cervical cancer prevention servicesPrevention programsHIV-negative womenInvasive cervical cancerCancer prevention servicesCervical cancer preventionExpert physician opinionHIV/AIDS programsElectronic medical recordsLow-resource countriesProportion of womenSame-day servicesLow-resource settingsUnscreened womenEvaluable dataCervical diseaseCervical cancerScreening servicesMedical recordsCancer preventionCervical precancer
2014
Clinical Performance of Digital Cervicography and Cytology for Cervical Cancer Screening in HIV-Infected Women in Lusaka, Zambia
Bateman AC, Parham GP, Sahasrabuddhe VV, Mwanahamuntu MH, Kapambwe S, Katundu K, Nkole T, Mulundika J, Pfaendler KS, Hicks ML, Shibemba A, Vermund SH, Stringer JS, Chibwesha CJ. Clinical Performance of Digital Cervicography and Cytology for Cervical Cancer Screening in HIV-Infected Women in Lusaka, Zambia. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 67: 212-215. PMID: 24977474, PMCID: PMC4162769, DOI: 10.1097/qai.0000000000000270.Peer-Reviewed Original ResearchConceptsClinical performanceDigital cervicographyCervical intraepithelial neoplasia grade 2High-grade squamous intraepithelial lesionsCervical cancer screeningSquamous intraepithelial lesionsIntraepithelial lesionsCancer screeningCervicographyGrade 2HIVCytologyWomenLesionsVisual inspectionSpecificityMonitoring the performance of “screen‐and‐treat” cervical cancer prevention programs
Mwanahamuntu MH, Sahasrabuddhe VV, Blevins M, Kapambwe S, Shepherd BE, Chibwesha C, Pfaendler KS, Mkumba G, Vwalika B, Hicks ML, Vermund SH, Stringer JSA, Parham GP. Monitoring the performance of “screen‐and‐treat” cervical cancer prevention programs. International Journal Of Gynecology & Obstetrics 2014, 126: 88-89. PMID: 24810795, PMCID: PMC4123629, DOI: 10.1016/j.ijgo.2014.01.006.Peer-Reviewed Original ResearchPediatric Malignancies, Treatment Outcomes and Abandonment of Pediatric Cancer Treatment in Zambia
Slone JS, Chunda-Liyoka C, Perez M, Mutalima N, Newton R, Chintu C, Kankasa C, Chipeta J, Heimburger DC, Vermund SH, Friedman DL. Pediatric Malignancies, Treatment Outcomes and Abandonment of Pediatric Cancer Treatment in Zambia. PLOS ONE 2014, 9: e89102. PMID: 24586527, PMCID: PMC3931678, DOI: 10.1371/journal.pone.0089102.Peer-Reviewed Original ResearchConceptsUniversity Teaching HospitalPediatric oncology wardOncology wardTreatment abandonmentRisk factorsTreatment outcomesRetrospective cohort studyAbandonment of treatmentMode of diagnosisCohort of childrenClinical medical recordsStudy time periodCohort studyOncologic treatmentTreatment regimenMultivariable analysisMedical recordsTeaching hospitalInclusion criteriaLower riskCancerChildrenTreatmentWardsDiagnosisHPTN 071 (PopART): Rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment – a study protocol for a cluster randomised trial
Hayes R, Ayles H, Beyers N, Sabapathy K, Floyd S, Shanaube K, Bock P, Griffith S, Moore A, Watson-Jones D, Fraser C, Vermund SH, Fidler S, The HPTN 071 (PopART) Study Team. HPTN 071 (PopART): Rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment – a study protocol for a cluster randomised trial. Trials 2014, 15: 57. PMID: 24524229, PMCID: PMC3929317, DOI: 10.1186/1745-6215-15-57.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnti-HIV AgentsCircumcision, MaleClinical ProtocolsCost-Benefit AnalysisDrug Administration ScheduleFemaleHealth Care CostsHIV InfectionsHumansIncidenceMaleMass ScreeningPredictive Value of TestsPrevalenceResearch DesignSouth AfricaTime FactorsTreatment OutcomeYoung AdultZambiaConceptsImmediate antiretroviral treatmentAntiretroviral treatmentHIV incidenceHIV testingCombination HIV prevention packageHIV combination prevention interventionsHome-based HIV testingUniversal testingCombination prevention interventionsHIV prevention packageHPTN 071 (PopART) trialUniversal HIV testingHIV-negative menCluster-randomised trialCurrent national guidelinesStandard of careMedical male circumcisionPublic health problemThree-arm designPotential adverse effectsART initiationHPTN 071Testing HIVSecondary outcomesArm BHPTN 071 (PopART): A Cluster-Randomized Trial of the Population Impact of an HIV Combination Prevention Intervention Including Universal Testing and Treatment: Mathematical Model
Cori A, Ayles H, Beyers N, Schaap A, Floyd S, Sabapathy K, Eaton JW, Hauck K, Smith P, Griffith S, Moore A, Donnell D, Vermund SH, Fidler S, Hayes R, Fraser C, . HPTN 071 (PopART): A Cluster-Randomized Trial of the Population Impact of an HIV Combination Prevention Intervention Including Universal Testing and Treatment: Mathematical Model. PLOS ONE 2014, 9: e84511. PMID: 24454728, PMCID: PMC3893126, DOI: 10.1371/journal.pone.0084511.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyArm AHIV incidenceHIV transmissionThree-arm cluster-randomized trialHIV combination prevention interventionsPopulation-level HIV incidenceCombination prevention interventionsCombination prevention packageHPTN 052 trialHPTN 071 (PopART) trialPopulation-level incidenceHIV-positive individualsHeterosexual HIV transmissionUptake of testingNational surveillance dataCluster-randomized trialImpact of treatmentLarge population clustersART retentionHPTN 071Primary endpointArm BPrevention packageControl arm
2013
Utilization of Cervical Cancer Screening Services and Trends in Screening Positivity Rates in a ‘Screen-And-Treat’ Program Integrated with HIV/AIDS Care in Zambia
Mwanahamuntu MH, Sahasrabuddhe VV, Blevins M, Kapambwe S, Shepherd BE, Chibwesha C, Pfaendler KS, Mkumba G, Vwalika B, Hicks ML, Vermund SH, Stringer JS, Parham GP. Utilization of Cervical Cancer Screening Services and Trends in Screening Positivity Rates in a ‘Screen-And-Treat’ Program Integrated with HIV/AIDS Care in Zambia. PLOS ONE 2013, 8: e74607. PMID: 24058599, PMCID: PMC3776830, DOI: 10.1371/journal.pone.0074607.Peer-Reviewed Original ResearchConceptsCervical cancer screening servicesCancer screening servicesHIV-seronegative womenHIV serostatusScreening servicesHIV/AIDS care programsCervical cancer prevention programsCervical cancer prevention servicesCervical cancer screening programsHIV/AIDS careHIV-seropositive womenCancer prevention servicesCancer prevention programsCancer screening programsAIDS care programsProportion of womenPatterns of utilizationHIV-seropositiveCervical cancerSaharan AfricaTest positivityPositivity rateAIDS careScreening programMultivariable modeling