2022
Voluntary Medical Male Circumcision to Reduce HIV Acquisition and Transmission
Vermund S. Voluntary Medical Male Circumcision to Reduce HIV Acquisition and Transmission. Current HIV/AIDS Reports 2022, 19: 471-473. PMID: 36478080, PMCID: PMC10767716, DOI: 10.1007/s11904-022-00631-z.Peer-Reviewed Original ResearchConceptsHIV acquisitionVoluntary medical male circumcisionHIV infection acquisitionVoluntary medical male circumcision (VMMC) programsMinor surgical interventionsMale circumcision programsHIV incidence ratesHigh HIV prevalenceMedical male circumcisionFirst clinical trialUninfected menHIV incidenceHIV prevalenceInfection acquisitionSaharan AfricaSurgical interventionCircumcision programsClinical trialsIncidence ratePreventive benefitsHIV riskCircumcision ratesRecent FindingsSinceMale circumcisionHealth section
2020
Incident HIV among pregnant and breast-feeding women in sub-Saharan Africa: a systematic review and meta-analysis.
Graybill LA, Kasaro M, Freeborn K, Walker JS, Poole C, Powers KA, Mollan KR, Rosenberg NE, Vermund SH, Mutale W, Chi BH. Incident HIV among pregnant and breast-feeding women in sub-Saharan Africa: a systematic review and meta-analysis. AIDS 2020, 34: 761-776. PMID: 32167990, PMCID: PMC7275092, DOI: 10.1097/qad.0000000000002487.Peer-Reviewed Original ResearchConceptsBreast-feeding womenMaternal HIV incidenceHIV incidenceHIV acquisitionIncidence rateHIV preventionSystematic reviewHigh HIV incidencePartner's HIV statusHIV incidence ratesCombination HIV preventionNonpregnant periodsIncident HIVTreatment landscapeHIV statusSaharan AfricaElevated riskSummary estimatesRelevant conferencesIncidenceAverage incidenceLimited evidenceWomenCalendar timePrevention
2019
Treatment as Prevention: Concepts and Challenges for Reducing HIV Incidence
Brault MA, Spiegelman D, Hargreaves J, Nash D, Vermund SH. Treatment as Prevention: Concepts and Challenges for Reducing HIV Incidence. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 82: s104-s112. PMID: 31658196, PMCID: PMC6820703, DOI: 10.1097/qai.0000000000002168.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyHIV transmissionHIV plasma loadReducing HIV IncidenceHIV prevention trialsCommunity-level interventionsDeployable vaccineViral suppressionHIV testingHIV incidencePrevention trialsUninfected personsChronic conditionsHIV investmentsEarly treatmentTreat strategySexual partnersViral expressionTransmission riskHIVTrialsTreatmentInconsistent findingsPreventionSaharan AfricaPromoting progress in child survival across four African countries: the role of strong health governance and leadership in maternal, neonatal and child health
Haley CA, Brault MA, Mwinga K, Desta T, Ngure K, Kennedy SB, Maimbolwa M, Moyo P, Vermund SH, Kipp AM, Kabaka S, Sergon K, Clarke A, Duworko M, Kalesha-Masumbu P, Katepa-Bwalya M, Madzima B, Kanyowa T, Habimana P. Promoting progress in child survival across four African countries: the role of strong health governance and leadership in maternal, neonatal and child health. Health Policy And Planning 2019, 34: 24-36. PMID: 30698696, PMCID: PMC6479825, DOI: 10.1093/heapol/czy105.Peer-Reviewed Original ResearchConceptsChild survivalChild mortalityChild healthWorld Health Organization (WHO) African RegionCoordination of servicesSaharan AfricaHealth governanceMortalityDevelopment GoalsCurrent sustainable development goalsStudy countriesSurvivalMNCHPace of reductionTwo-thirdsHealth leadershipSustainable Development GoalsMillennium Development GoalsCross-country analysisAfrican regionFour-country studyTop national priorityHealthSufficient humanIndividual case studies
2015
Implementation and Operational Research
Kapambwe S, Sahasrabuddhe VV, Blevins M, Mwanahamuntu MH, Mudenda V, Shepherd BE, Chibwesha CJ, Pfaendler KS, Hicks ML, Vermund SH, Stringer JS, Parham GP. Implementation and Operational Research. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2015, 70: e20-e26. PMID: 26322673, PMCID: PMC4791059, DOI: 10.1097/qai.0000000000000685.Peer-Reviewed Original ResearchConceptsUnknown HIV serostatusHIV serostatusYoung womenCervical cancerOlder womenHIV/AIDS care programsCervical cancer prevention programsInvasive cervical cancer casesRisk of ICCHIV-seronegative womenHIV-seropositive womenIndependent risk factorCancer prevention programsCervical cancer casesMultivariable logistic regressionAIDS care programsLifetime sexual partnersHIV infectionSaharan AfricaRisk factorsCancer casesAge 35High riskICC casesCare programIdentification of invasive Salmonella enterica serovar Typhimurium ST313 in ambulatory HIV-infected adults in Mozambique
Moon TD, Johnson M, Foster MA, Silva WP, Buene M, Valverde E, Morais L, Williams JV, Vermund SH, Brentlinger PE. Identification of invasive Salmonella enterica serovar Typhimurium ST313 in ambulatory HIV-infected adults in Mozambique. Journal Of Global Infectious Diseases 2015, 7: 139-142. PMID: 26751031, PMCID: PMC4693304, DOI: 10.4103/0974-777x.170496.Peer-Reviewed Original ResearchMultilocus sequence typingAmbulatory HIVINTS diseaseInvasive non-typhoidal salmonella (iNTS) diseaseTyphimurium ST313Non-typhoidal salmonella diseaseS. Typhimurium ST313Multiple sub-Saharan African countriesBlood isolatesSalmonella diseaseMozambican adultsPredominant causeTreatment initiativesTyphimurium ST19Salmonella enterica serovar TyphimuriumST313Vulnerable populationsSequence typingDiseaseEnterica serovar TyphimuriumHIVPositive controlSub-Saharan African countriesSequence typesSaharan Africa
2014
HIV and Noncommunicable Disease Comorbidities in the Era of Antiretroviral Therapy
Narayan KM, Miotti PG, Anand NP, Kline LM, Harmston C, Gulakowski R, Vermund SH. HIV and Noncommunicable Disease Comorbidities in the Era of Antiretroviral Therapy. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 67: s2-s7. PMID: 25117958, DOI: 10.1097/qai.0000000000000267.Peer-Reviewed Original ResearchConceptsNoncommunicable diseasesChronic immune activationMedication side effectsAntiretroviral therapy programsSubstance use disordersNCD comorbidityAntiretroviral therapyMiddle-income countriesPulmonary diseaseImmune activationGenitourinary diseasesBone disordersDisease comorbiditiesSide effectsUse disordersTherapy programHIVDiseaseComorbiditiesInvestigator teamNutritional aspectsDisordersSaharan AfricaAging processCoinfection
2013
Utilization of Cervical Cancer Screening Services and Trends in Screening Positivity Rates in a ‘Screen-And-Treat’ Program Integrated with HIV/AIDS Care in Zambia
Mwanahamuntu MH, Sahasrabuddhe VV, Blevins M, Kapambwe S, Shepherd BE, Chibwesha C, Pfaendler KS, Mkumba G, Vwalika B, Hicks ML, Vermund SH, Stringer JS, Parham GP. Utilization of Cervical Cancer Screening Services and Trends in Screening Positivity Rates in a ‘Screen-And-Treat’ Program Integrated with HIV/AIDS Care in Zambia. PLOS ONE 2013, 8: e74607. PMID: 24058599, PMCID: PMC3776830, DOI: 10.1371/journal.pone.0074607.Peer-Reviewed Original ResearchConceptsCervical cancer screening servicesCancer screening servicesHIV-seronegative womenHIV serostatusScreening servicesHIV/AIDS care programsCervical cancer prevention programsCervical cancer prevention servicesCervical cancer screening programsHIV/AIDS careHIV-seropositive womenCancer prevention servicesCancer prevention programsCancer screening programsAIDS care programsProportion of womenPatterns of utilizationHIV-seropositiveCervical cancerSaharan AfricaTest positivityPositivity rateAIDS careScreening programMultivariable modelingPhysician Emigration from Sub-Saharan Africa to the United States: Analysis of the 2011 AMA Physician Masterfile
Tankwanchi AB, Özden Ç, Vermund SH. Physician Emigration from Sub-Saharan Africa to the United States: Analysis of the 2011 AMA Physician Masterfile. PLOS Medicine 2013, 10: e1001513. PMID: 24068894, PMCID: PMC3775724, DOI: 10.1371/journal.pmed.1001513.Peer-Reviewed Original ResearchConceptsPhysician MasterfileAmerican Medical Association Physician MasterfileAMA Physician MasterfileYears of practicePhysician emigrationPhysician dataPhysiciansActive physiciansLength of timeEditors' SummarySSA countriesMasterfilePhysician workforceSaharan AfricaWorkforce statisticsUnited StatesImplementation yearResidency dataYearsHigh-income nationsSub-Saharan AfricaUS entryGreat needTranslation of Biomedical Prevention Strategies for HIV
Vermund SH, Tique JA, Cassell HM, Pask ME, Ciampa PJ, Audet CM. Translation of Biomedical Prevention Strategies for HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2013, 63: s12-s25. PMID: 23673881, PMCID: PMC3725750, DOI: 10.1097/qai.0b013e31829202a2.Peer-Reviewed Original ResearchConceptsPrevention of motherPrevention strategiesClean injection equipmentChild HIV transmissionBiomedical approachBiomedical prevention strategiesRisk of acquisitionHIV prevention strategiesBehavioral risk reductionHigh-prevalence regionsRisk of transmissionCircumcision of menBlood product safetyChild transmissionHIV transmissionAntiretroviral drugsPrevalence regionsHIV preventionHIVFamily planningMore childrenPreventionRisk reductionInjection equipmentSaharan Africa
2011
Enrolment and programmatic trends and predictors of antiretroviral therapy initiation from President's Emergency Plan for AIDS Relief (PEPFAR)-supported public HIV care and treatment sites in rural Mozambique
Moon TD, Burlison JR, Blevins M, Shepherd BE, Baptista A, Sidat M, Vergara AE, Vermund SH. Enrolment and programmatic trends and predictors of antiretroviral therapy initiation from President's Emergency Plan for AIDS Relief (PEPFAR)-supported public HIV care and treatment sites in rural Mozambique. International Journal Of STD & AIDS 2011, 22: 621-627. PMID: 22096045, DOI: 10.1258/ijsa.2011.010442.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyART initiationAntiretroviral therapy initiationHIV treatment programsCells/μLContinuous drug supplyPresident's Emergency PlanHIV careTherapy initiationHIV testingMedian ageSaharan AfricaTreatment expansionZambézia ProvinceRoutine dataPatient record systemPatientsTreatment programOlder ageAIDS ReliefHealth manpowerCells/Drug supplyRecord systemTreatment sites
2009
Adult combination antiretroviral therapy in sub-Saharan Africa: lessons from Botswana and future challenges
Wester CW, Bussmann H, Koethe J, Moffat C, Vermund S, Essex M, Marlink RG. Adult combination antiretroviral therapy in sub-Saharan Africa: lessons from Botswana and future challenges. HIV Therapy 2009, 3: 501-526. PMID: 20161344, PMCID: PMC2774911, DOI: 10.2217/hiv.09.35.Peer-Reviewed Original ResearchCombination antiretroviral therapyAntiretroviral therapyUse of cARTFirst-line combination antiretroviral therapyHIV-1-infected adultsPrimary HIV-1 infectionMonths of treatmentHIV-1 infectionResource-rich settingsHigh mortality rateImmunologic recoveryVirologic suppressionHIV infectionHealthcare utilizationSaharan AfricaAdherence ratesLifelong monitoringPROGRESS trialTreatment outcomesMortality rateCART programClinical servicesImpressive declineTherapyInfection
2004
Antiretroviral therapy in sub-Saharan Africa: adherence lessons from tuberculosis and leprosy
Reid SE, Reid CA, Vermund SH. Antiretroviral therapy in sub-Saharan Africa: adherence lessons from tuberculosis and leprosy. International Journal Of STD & AIDS 2004, 15: 713-716. PMID: 15537453, DOI: 10.1258/0956462042395195.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyInfected personsAntiretroviral treatment programAntiretroviral drug therapyHuman immunodeficiency virusResource-limited settingsAdherence strategiesImmunodeficiency virusSaharan AfricaAdequate adherenceDrug therapyDrug costsLeprosy controlTreatment programTherapyTuberculosisLeprosyAdherenceControl programs
2002
Transmission of HIV
Kristensen S, Sinkala M, Vermund S. Transmission of HIV. 2002, 217-230. DOI: 10.1007/0-306-47817-x_13.Peer-Reviewed Original ResearchSafe male circumcisionSustained antiretroviral therapyTransmission of HIVProportion of infectionsSexual partner numberAntiretroviral therapyHIV vaccineSexual exposureHIV preventionSTD treatmentHuman studiesMale circumcisionCondom useMale partnersBehavioral interventionsPartner numbersEmployment-related exposureInterventionHIVAdditional strategiesLower ratesHigh rateLimited valueSaharan AfricaExposure
2000
Cost-Effective Use of Nevirapine to Prevent Vertical HIV Transmission in Sub-Saharan Africa
Stringer J, Rouse D, Vermund S, Goldenberg R, Sinkala M, Stinnett A. Cost-Effective Use of Nevirapine to Prevent Vertical HIV Transmission in Sub-Saharan Africa. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 24: 369-377. DOI: 10.1097/00042560-200008010-00012.Peer-Reviewed Original ResearchConceptsVertical HIV transmissionHIV transmissionPrenatal carePrevention strategiesEffects of NVPModest clinical efficacyOptimal prevention strategiesGreater health gainsDecision analysis modelNevirapine administrationNVP administrationPrenatal visitPreventive therapyStandard therapyClinical efficacySaharan AfricaMass therapyPrenatal strategiesClinical assessmentPrior enrollmentTherapyCost-effective useHealth gainsWomenSerostatusCost-Effective Use of Nevirapine to Prevent Vertical HIV Transmission in Sub-Saharan Africa
Stringer J, Rouse D, Vermund S, Goldenberg R, Sinkala M, Stinnett A. Cost-Effective Use of Nevirapine to Prevent Vertical HIV Transmission in Sub-Saharan Africa. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 24: 369-377. DOI: 10.1097/00126334-200008010-00010.Peer-Reviewed Original ResearchVertical HIV transmissionHIV transmissionPrenatal carePrevention strategiesEffects of NVPModest clinical efficacyOptimal prevention strategiesGreater health gainsDecision analysis modelNevirapine administrationNVP administrationPrenatal visitPreventive therapyStandard therapyClinical efficacySaharan AfricaMass therapyPrenatal strategiesClinical assessmentPrior enrollmentTherapyCost-effective useHealth gainsWomenSerostatusCost-effective use of nevirapine to prevent vertical HIV transmission in sub-Saharan Africa.
Stringer J, Rouse D, Vermund S, Goldenberg R, Sinkala M, Stinnett A. Cost-effective use of nevirapine to prevent vertical HIV transmission in sub-Saharan Africa. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 24: 369-77. PMID: 11015154, DOI: 10.1097/00126334-200008010-00012.Peer-Reviewed Original ResearchConceptsVertical HIV transmissionHIV transmissionPrenatal carePrevention strategiesEffects of NVPModest clinical efficacyOptimal prevention strategiesSaharan AfricaGreater health gainsDecision analysis modelNevirapine administrationNVP administrationPrenatal visitPreventive therapyStandard therapyClinical efficacyMass therapyPrenatal strategiesClinical assessmentPrior enrollmentTherapyCost-effective useHealth gainsWomenSerostatus