2022
Interplay of Lymphocytes with the Intestinal Microbiota in Children with Nonalcoholic Fatty Liver Disease
Liang T, Li D, Zunong J, Li M, Amaerjiang N, Xiao H, Khattab N, Vermund S, Hu Y. Interplay of Lymphocytes with the Intestinal Microbiota in Children with Nonalcoholic Fatty Liver Disease. Nutrients 2022, 14: 4641. PMID: 36364902, PMCID: PMC9657134, DOI: 10.3390/nu14214641.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseFatty liver diseaseHigher lymphocyte countsLymphocyte countGut microbiotaLiver diseaseHealthy childrenGut microbiota dysbiosisEffect of lymphocytesProinflammatory bacteriaMicrobiota dysbiosisRisk factorsIntestinal microbiotaAbundance of BacteroidetesLymphocytesMicrobiotaChildrenOpportunistic pathogenDiseaseCountMetagenomic sequencingLow numberHigher numberDysbiosisGroup
2020
Public Health and Clinical Implications of Nutrition-Infection Interactions
Vermund S, Scott M, Humphries D. Public Health and Clinical Implications of Nutrition-Infection Interactions. Nutrition And Health 2020, 459-481. DOI: 10.1007/978-3-030-56913-6_16.Peer-Reviewed Original ResearchInfectious agentsNutritional statusClinical implicationsRole of obesityDefinitive risk factorsSeverity of malariaSuboptimal nutritional statusMajor infectious agentsHealth of personsClinical courseClinical managementRisk factorsClinical nutritionHigh mortalityInfectious diseasesCOVID-19ObesityPublic healthInfectionDiseaseSeverityNutritionHealthBacterial diseasesStatusHIV Seroconversion and Types of Relationships Among Men Who Have Sex With Men: A Cohort Study in China.
Sun X, Wang C, Zhao K, Zhang L, Li M, Sun D, Shu W, Ruan Y, Zhang J, Vermund SH, Li D, Hu Y. HIV Seroconversion and Types of Relationships Among Men Who Have Sex With Men: A Cohort Study in China. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2020, 83: 365-372. PMID: 31913999, PMCID: PMC7055498, DOI: 10.1097/qai.0000000000002264.Peer-Reviewed Original ResearchConceptsHIV seroconversionSeroconversion riskHIV seroconversion ratesHIV seroconversion riskMultivariable Cox regressionHIV-negative menIncident HIV infectionRegular sexual partnersRelative excess riskUnprotected anal sexSexual behaviorLast sexual encounterUnsafe sexual behaviorSafer sex educationSeroconversion ratesCohort studyHIV infectionRisky sexual behaviorHIV statusCox regressionExcess riskRisk factorsRegular partnersLow educational attainmentCasual partners
2019
Syphilis associated with recreational drug use, depression and high-risk sexual behaviour in men who have sex with men: a case–control study in China
Wu H, Xiu C, Fu X, Li M, Wang Z, Li X, Wu J, Vermund SH, Hu Y. Syphilis associated with recreational drug use, depression and high-risk sexual behaviour in men who have sex with men: a case–control study in China. Sexually Transmitted Infections 2019, 95: 267-272. PMID: 30842346, PMCID: PMC11093516, DOI: 10.1136/sextrans-2018-053878.Peer-Reviewed Original ResearchConceptsRecreational drug useHigh-risk sexual behaviorCase-control studyDrug useSyphilis infectionToluidine red unheated serum testUnmatched case-control studyRed unheated serum testMultivariable logistic regressionPotential risk factorsMultiple drug useSexual behaviorPrior STIFrequent methamphetamine useSyphilis prevalenceSyphilis testingRisk factorsSerum testHealth workersDepression scoresSelf-administrated questionnaireRecreational drugsLogistic regressionSyphilisMethamphetamine use
2018
Surveillance of Maternal Syphilis in China: Pregnancy Outcomes and Determinants of Congenital Syphilis
Zhang X, Yu Y, Yang H, Xu H, Vermund SH, Liu K. Surveillance of Maternal Syphilis in China: Pregnancy Outcomes and Determinants of Congenital Syphilis. Medical Science Monitor 2018, 24: 7727-7735. PMID: 30370903, PMCID: PMC6216479, DOI: 10.12659/msm.910216.Peer-Reviewed Original ResearchConceptsAdverse pregnancy outcomesPregnancy outcomesCongenital syphilisPregnant womenFirst antenatal care visitEligible pregnant womenPrevention of motherAntenatal care visitsIndependent risk factorMultivariable regression analysisLogistic regression analysisRegression analysisChild transmissionMaternal syphilisAntenatal careCare visitsNeonatal asphyxiaNeonatal deathFirst trimesterRisk womenAntibody titersAntenatal testingEpidemiological characteristicsRisk factorsSyphilis diagnosis
2017
Effects of depression and anxiety on antiretroviral therapy adherence among newly diagnosed HIV-infected Chinese MSM
Tao J, Qian HZ, Kipp AM, Ruan Y, Shepherd BE, Amico KR, Shao Y, Lu H, Vermund SH. Effects of depression and anxiety on antiretroviral therapy adherence among newly diagnosed HIV-infected Chinese MSM. AIDS 2017, 31: 401-406. PMID: 27677168, PMCID: PMC5233466, DOI: 10.1097/qad.0000000000001287.Peer-Reviewed Original ResearchConceptsImperfect ART adherenceEffect of depressionART adherenceAntiretroviral therapyHIV infectionChinese MSMHIV treatment outcomesAntiretroviral therapy adherenceEnd of studyMixed-effects logistic regressionHIV diagnosisOne-unit increaseProspective studyTherapy adherenceHospital AnxietyRisk factorsTreatment outcomesDepression ScaleSignificant associationIntensive interventionLogistic regressionMSMAnxiety scoresAdherenceInfection
2016
Substance use and HIV-risk behaviors among HIV-positive men who have sex with men in China: repeated measures in a cohort study design
Zhang C, Liu Y, Sun X, Wang J, Lu HY, He X, Zhang H, Ruan YH, Shao Y, Vermund SH, Qian HZ. Substance use and HIV-risk behaviors among HIV-positive men who have sex with men in China: repeated measures in a cohort study design. AIDS Care 2016, 29: 644-653. PMID: 27832699, PMCID: PMC5350012, DOI: 10.1080/09540121.2016.1255709.Peer-Reviewed Original ResearchConceptsHIV risk behaviorsCohort study designSubstance useStudy designHIV-positive MSMHIV-positive menGeneralized Estimating Equation modelsFemale sex partnersRapid HIV transmissionMale sexual partnersRigorous study designsSexual risk behaviorsCurrent studySeronegative counterpartsSeropositive menSeropositive partnersHIV transmissionMean agePotential confoundersRisk factorsHigh riskRisk populationsSex partnersUnprotected sexRisk behaviorsRisk Factors for Loss to Follow-Up among People Who Inject Drugs in a Risk Reduction Program at Karachi, Pakistan. A Case-Cohort Study
Samo RN, Agha A, Shah SA, Altaf A, Memon A, Blevins M, Qian HZ, Vermund SH. Risk Factors for Loss to Follow-Up among People Who Inject Drugs in a Risk Reduction Program at Karachi, Pakistan. A Case-Cohort Study. PLOS ONE 2016, 11: e0147912. PMID: 26840414, PMCID: PMC4739707, DOI: 10.1371/journal.pone.0147912.Peer-Reviewed Original ResearchConceptsCase-cohort studyMale PWIDHarm reduction programsRisk reduction programsRisk factorsReduction programsNeedle/syringe exchangeProspective cohort studyMultivariable logistic regressionResource-limited settingsHistory of incarcerationCohort studyMedian ageIncidence rateSyringe exchangePWIDMale peopleYounger ageLogistic regressionYoung menMonthsKarachiMenActive outreachProgrammatic challengesC-107 Stigma and depression among newly diagnosed HIV infected MSM in China
Tao J, Wang L, Kipp A, Qian H, Yin L, Ruan Y, Shao Y, Lu H, Vermund S. C-107 Stigma and depression among newly diagnosed HIV infected MSM in China. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2016, 71: 49. DOI: 10.1097/01.qai.0000479593.51216.ff.Peer-Reviewed Original ResearchInternalized stigmaRisk factorsStigma scoresRandomized clinical trialsAntiretroviral therapyHIV acquisitionPotential social isolationHIV diagnosisHospital AnxietyCare continuumClinical trialsDepression ScaleChinese MSMHigh riskHIVExploratory factor analysisStigma ScaleLogistic regressionMedian scoreBaseline surveyMSMStrong associationDepressionSocial isolationScores
2015
Implementation and Operational Research
Kapambwe S, Sahasrabuddhe VV, Blevins M, Mwanahamuntu MH, Mudenda V, Shepherd BE, Chibwesha CJ, Pfaendler KS, Hicks ML, Vermund SH, Stringer JS, Parham GP. Implementation and Operational Research. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2015, 70: e20-e26. PMID: 26322673, PMCID: PMC4791059, DOI: 10.1097/qai.0000000000000685.Peer-Reviewed Original ResearchConceptsUnknown HIV serostatusHIV serostatusYoung womenCervical cancerOlder womenHIV/AIDS care programsCervical cancer prevention programsInvasive cervical cancer casesRisk of ICCHIV-seronegative womenHIV-seropositive womenIndependent risk factorCancer prevention programsCervical cancer casesMultivariable logistic regressionAIDS care programsLifetime sexual partnersHIV infectionSaharan AfricaRisk factorsCancer casesAge 35High riskICC casesCare programNatural history and epidemiology of respiratory syncytial virus infection in the Middle East: Hospital surveillance for children under age two in Jordan
Halasa N, Williams J, Faouri S, Shehabi A, Vermund SH, Wang L, Fonnesbeck C, Khuri-Bulos N. Natural history and epidemiology of respiratory syncytial virus infection in the Middle East: Hospital surveillance for children under age two in Jordan. Vaccine 2015, 33: 6479-6487. PMID: 26314623, PMCID: PMC7115487, DOI: 10.1016/j.vaccine.2015.08.048.Peer-Reviewed Original ResearchMeSH KeywordsEpidemiological MonitoringFemaleHospitalsHumansInfantInfant, NewbornJordanMaleMass SpectrometryNasal MucosaPharynxPrevalenceProspective StudiesReal-Time Polymerase Chain ReactionRespiratory Syncytial Virus InfectionsRespiratory Tract InfectionsReverse Transcriptase Polymerase Chain ReactionRisk FactorsVitamin DConceptsRespiratory syncytial virusRSV-positive childrenVitamin D levelsD levelsRespiratory virusesRisk factorsMedical conditionsBurden of RSVOxygen useMedian vitamin D levelNasal/throat swabsRespiratory syncytial virus infectionCause of bronchiolitisHeel stick bloodSyncytial virus infectionLack of breastfeedingSupplemental oxygen useHigh viral loadFuture RSV vaccinesYoung childrenReal-time RT-PCRRSV hospitalizationRespiratory symptomsRSV vaccineAntiviral therapyPrevalence and risk factors of cervical squamous intraepithelial lesions among HIV-infected women in Dar es Salaam, Tanzania
Liu E, McCree R, Mtisi E, Fawzi WW, Aris E, Lema IA, Hertzmark E, Chalamilla G, Li N, Vermund SH, Spiegelman D. Prevalence and risk factors of cervical squamous intraepithelial lesions among HIV-infected women in Dar es Salaam, Tanzania. International Journal Of STD & AIDS 2015, 27: 219-225. PMID: 25957324, PMCID: PMC11340030, DOI: 10.1177/0956462415584466.Peer-Reviewed Original ResearchConceptsCervical squamous intraepithelial lesionsSquamous intraepithelial lesionsHIV disease stageCell countIntraepithelial lesionsDisease stageHigh-grade squamous intraepithelial lesionsAdvanced HIV disease stageCervical cancer prevention servicesLow CD4 cell countsCD4 cell countCancer prevention servicesCross-sectional studyResource-limited settingsCervical inflammationLow CD4Median CD4HIV careMedian ageCervical screeningPapanicolaou smearsRisk factorsTreatment clinicsPrevention servicesHIV
2014
Helminth prevalence among adults in rural Kenya: a stool survey for soil-transmitted helminths and schistosomiasis in Nyanza province
Andereck JW, Kipp AM, Ondiek M, Vermund SH. Helminth prevalence among adults in rural Kenya: a stool survey for soil-transmitted helminths and schistosomiasis in Nyanza province. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 2014, 108: 804-809. PMID: 25359321, DOI: 10.1093/trstmh/tru164.Peer-Reviewed Original ResearchConceptsSTH prevalenceRisk factorsSoil-transmitted helminth prevalenceHelminth prevalenceNyanza ProvinceOut-patient departmentMultivariable regression modelsSoil-transmitted helminthsStool concentration techniqueLow education levelFemale sexStool samplesStool surveyCommunity outreach eventsTrichuris trichiuraSame villagePrevalence dataOlder agePrevalenceSchistosoma mansoniSmall hospitalsShort questionnaireAdultsRural KenyaAnthelmintic drugsHIV and syphilis prevalence trends among men who have sex with men in Guangxi, China: yearly cross-sectional surveys, 2008–2012
Wang X, Lan G, Shen Z, Vermund SH, Zhu Q, Chen Y, Khoshnood K, Wu Z, Tang Z. HIV and syphilis prevalence trends among men who have sex with men in Guangxi, China: yearly cross-sectional surveys, 2008–2012. BMC Infectious Diseases 2014, 14: 367. PMID: 24993252, PMCID: PMC4091643, DOI: 10.1186/1471-2334-14-367.Peer-Reviewed Original ResearchConceptsYears of ageSyphilis prevalenceCross-sectional surveyCurrent syphilisHIV prevalencePrevalence trendsSexual intercourseIncident HIV casesAnnual cross-sectional surveyRisk factor dataSignificant predictorsRisk of HIVNational sentinel surveillanceYearly cross-sectional surveysHIV/AIDSSyphilis infectionHIV infectionHIV casesSentinel surveillanceRisk factorsBlood samplesHIVKey populationsMSMPrevalencePediatric Malignancies, Treatment Outcomes and Abandonment of Pediatric Cancer Treatment in Zambia
Slone JS, Chunda-Liyoka C, Perez M, Mutalima N, Newton R, Chintu C, Kankasa C, Chipeta J, Heimburger DC, Vermund SH, Friedman DL. Pediatric Malignancies, Treatment Outcomes and Abandonment of Pediatric Cancer Treatment in Zambia. PLOS ONE 2014, 9: e89102. PMID: 24586527, PMCID: PMC3931678, DOI: 10.1371/journal.pone.0089102.Peer-Reviewed Original ResearchConceptsUniversity Teaching HospitalPediatric oncology wardOncology wardTreatment abandonmentRisk factorsTreatment outcomesRetrospective cohort studyAbandonment of treatmentMode of diagnosisCohort of childrenClinical medical recordsStudy time periodCohort studyOncologic treatmentTreatment regimenMultivariable analysisMedical recordsTeaching hospitalInclusion criteriaLower riskCancerChildrenTreatmentWardsDiagnosisRisk Factors for Delayed Initiation of Combination Antiretroviral Therapy in Rural North Central Nigeria
Aliyu MH, Blevins M, Parrish DD, Megazzini KM, Gebi UI, Muhammad MY, Ahmed ML, Hassan A, Shepherd BE, Vermund SH, Wester CW. Risk Factors for Delayed Initiation of Combination Antiretroviral Therapy in Rural North Central Nigeria. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 65: e41-e49. PMID: 23727981, PMCID: PMC3818360, DOI: 10.1097/qai.0b013e31829ceaec.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyAntiretroviral therapyDate of enrollmentART initiationCD4 countFunctional statusInitiation of ARTMedian CD4 countHigher CD4 countsLower functional statusMonths of enrollmentBody mass indexART eligibility criteriaAdults/adolescentsRural North-Central NigeriaHIV/AIDSQuality improvement effortsEligible HIVEligible patientsPatient characteristicsART uptakeMass indexRisk factorsTimely initiationDelayed initiation
2013
High HIV Incidence among Persons Who Inject Drugs in Pakistan: Greater Risk with Needle Sharing and Injecting Frequently among the Homeless
Samo RN, Altaf A, Agha A, Pasha O, Rozi S, Memon A, Azam S, Blevins M, Vermund SH, Shah SA. High HIV Incidence among Persons Who Inject Drugs in Pakistan: Greater Risk with Needle Sharing and Injecting Frequently among the Homeless. PLOS ONE 2013, 8: e81715. PMID: 24358123, PMCID: PMC3864804, DOI: 10.1371/journal.pone.0081715.Peer-Reviewed Original ResearchConceptsIncidence of HIVHIV seroconversionIncidence rateMultivariable Cox regression analysisNeedle/syringe exchangeCohort of PWIDHIV-seronegative personsHigh HIV incidenceOpiate substitution therapyCox regression analysisHIV incidence ratesHIV risk reductionSharing of syringesRisk reductionSubstance abuse treatmentSeronegative personsCohort studyRisk reduction programsHIV incidencePerson yearsSubstitution therapyDaily injectionsNeedle sharingRisk factorsPrevalence ratesImpact of HIV drug resistance on virologic and immunologic failure and mortality in a cohort of patients on antiretroviral therapy in China
Liao L, Xing H, Su B, Wang Z, Ruan Y, Wang X, Liu Z, Lu Y, Yang S, Zhao Q, Vermund SH, Chen RY, Shao Y. Impact of HIV drug resistance on virologic and immunologic failure and mortality in a cohort of patients on antiretroviral therapy in China. AIDS 2013, 27: 1815-1824. PMID: 23803794, PMCID: PMC3694318, DOI: 10.1097/qad.0b013e3283611931.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyHIV drug resistanceImmunologic failureHigh mortalityVirologic failureAntiretroviral therapyEmergence of HIVDRBaseline CD4 cell countDrug resistanceCD4 cell countCohort of patientsSecond-line drugsEnd of studyProportional hazards modelRural Chinese countiesHIVDR mutationsMedian timePatient adherenceKaplan-MeierChinese patientsRisk factorsHazards modelPatientsCell countMortality
2012
Increased Prevalence of Asthma Symptoms in Nigerian Children with Sickle Cell Disease Compared to Children without Sickle Cell Disease
Galadanci N, Liang W, Aliyu M, Jibir B, Karaye I, Inusa B, Vermund S, DeBaun M. Increased Prevalence of Asthma Symptoms in Nigerian Children with Sickle Cell Disease Compared to Children without Sickle Cell Disease. Blood 2012, 120: 4760. DOI: 10.1182/blood.v120.21.4760.4760.Peer-Reviewed Original ResearchAsthma-like symptomsSickle cell diseaseMurtala Mohammed Specialist HospitalMode of deliveryAsthma symptomsCell diseaseGestational agePhysician diagnosisRisk factorsHigh prevalenceParental historyNigerian childrenAmerican Thoracic Society DivisionLung Disease QuestionnaireHistory of coughPrevalence of asthmaDiagnosis of asthmaShortness of breathCase-control study designCause of morbidityDemographic informationRoutine medical careWilcoxon rank sum testChi-square testHigh rateTreatment outcomes of pediatric oncology patients in Zambia.
Slone J, Chunda-Liyoka C, Perez M, Mutalima N, Newton R, Chintu C, Kankasa C, Chipeta J, Heimburger D, Vermund S, Friedman D. Treatment outcomes of pediatric oncology patients in Zambia. Journal Of Clinical Oncology 2012, 30: 9558-9558. DOI: 10.1200/jco.2012.30.15_suppl.9558.Peer-Reviewed Original ResearchUniversity Teaching HospitalAbandonment of treatmentPediatric oncology careLow-middle income countriesOncology careCohort of patientsMajority of patientsMedical record reviewPalliative regimensCommon diagnosisRecord reviewDecreased riskRetrospective studyTreatment abandonmentHistopathological diagnosisRisk factorsKaposi's sarcomaTeaching hospitalTreatment outcomesInclusion criteriaAverage ageDiagnosisCohortWilms tumorCommon outcome