Characterization of Plasmodium developmental transcriptomes in Anopheles gambiae midgut reveals novel regulators of malaria transmission
Akinosoglou K, Bushell E, Ukegbu C, Schlegelmilch T, Cho J, Redmond S, Sala K, Christophides G, Vlachou D. Characterization of Plasmodium developmental transcriptomes in Anopheles gambiae midgut reveals novel regulators of malaria transmission. Cellular Microbiology 2014, 17: 254-268. PMID: 25225164, PMCID: PMC4371638, DOI: 10.1111/cmi.12363.Peer-Reviewed Original ResearchConceptsTranscriptional programsOokinete developmentRodent malaria parasite Plasmodium bergheiMalaria parasite Plasmodium bergheiDistinct transcriptional programsMosquito midgut invasionMalaria parasite populationsDevelopmental transcriptomeAnopheles gambiae mosquitoesPenetrant lossFunction phenotypesMidgut invasionHomologous recombinationGamete releasePlasmodium developmentMutant parasitesDevelopmental processesDNA microarraysGranular localizationInfection phenotypesEstablishment of infectionMosquito midgutShort polypeptidesParasite populationsParasite development