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    Serena Susan Spudich, MD, MA

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    Gilbert H. Glaser Professor of Neurology
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    Additional Titles

    Division Chief, Neurological Infections & Global Neurology

    Co-Director, Yale Center for Brain & Mind Health

    Affiliated Faculty, Yale Institute for Global Health

    About

    Titles

    Gilbert H. Glaser Professor of Neurology

    Division Chief, Neurological Infections & Global Neurology; Co-Director, Yale Center for Brain & Mind Health; Affiliated Faculty, Yale Institute for Global Health

    Appointments

    Other Departments & Organizations

    Education & Training

    Fellow
    University of California at San Francisco (2004)
    Fellow
    Harvard Medical School (2003)
    Resident
    Harvard Medical School (2002)
    Resident
    University of Washington School of Medicine (1999)
    Intern
    University of Washington School of Medicine (1998)
    MD
    University of California at San Francisco (1997)
    MA
    Stanford University, Philosophy of Science (1992)
    BA
    Stanford University, Human Biology/Humanities (1991)
    Fellowship
    University of California - San Francisco, CA

    Research

    Overview

    Medical Research Interests

    Acquired Immunodeficiency Syndrome; Antiviral Agents; Biomarkers; Cerebrospinal Fluid; COVID-19; Dementia; HIV; Nervous System; Neurodegenerative Diseases; Neuroinflammatory Diseases; Neurology; Positron-Emission Tomography; Post-Acute COVID-19 Syndrome; Virology

    Public Health Interests

    COVID-19; Biomarkers; Viruses; HIV/AIDS; Immunology; Infectious Diseases

    Research at a Glance

    Publications Timeline

    A big-picture view of Serena Susan Spudich's research output by year.
    227Publications
    12,590Citations

    Publications

    2026

    2025

    • Neuroaxonal Injury in Acute HIV Infection and Following Immediate Antiretroviral Therapy
      Chan P, Sacdalan C, Pinyakorn S, Kroon E, Colby D, Promsena P, Sriplienchan S, Phanuphak N, Vasan S, Valcour V, Paul R, Gisslén M, Zetterberg H, Trautmann L, Spudich S. Neuroaxonal Injury in Acute HIV Infection and Following Immediate Antiretroviral Therapy. Journal Of Infectious Diseases 2025, jiaf583. PMID: 41254882, DOI: 10.1093/infdis/jiaf583.
      Peer-Reviewed Original Research
    • Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV
      Holroyd K, Chan P, Sacdalan C, Dumrongpisutikul N, Sriplienchan S, Promensa P, Sailasuta P, Pothisri M, Puttamaswin S, Vasan S, Valcour V, Trautmann L, Spudich S, Paul R, Bolzenius J. Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV. Neurology 2025, 105: e214445. PMID: 41172230, PMCID: PMC12817266, DOI: 10.1212/wnl.0000000000214445.
      Peer-Reviewed Original Research
    • Neurosymptomatic Cerebrospinal Fluid Escape Is a Central Nervous System–Focused Form of Antiretroviral Therapy Treatment Failure
      Kincer L, Dravid A, Zhou S, Vercesi R, Spudich S, Gisslén M, Price R, Cinque P, Joseph S. Neurosymptomatic Cerebrospinal Fluid Escape Is a Central Nervous System–Focused Form of Antiretroviral Therapy Treatment Failure. Open Forum Infectious Diseases 2025, 13: ofaf659. PMID: 41488692, PMCID: PMC12760783, DOI: 10.1093/ofid/ofaf659.
      Peer-Reviewed Original Research
    • Antiretroviral Therapy Intensification With Dolutegravir and/or Maraviroc Did Not Affect HIV-1 Cell-Associated DNA, RNA, and 2­–LTR Circles Over 12 Weeks
      Reed J, Hall L, McKhann A, Kwak G, Goecker E, Coombs R, Chen H, Roa J, Vecchio A, Daar E, Hunt P, Marra C, Campbell T, Ma Q, Swaminathan S, Macatangay B, Morse G, Miller T, Rusin D, Ha B, Alston-Smith B, Paul R, Letendre S, Spudich S, Greninger A. Antiretroviral Therapy Intensification With Dolutegravir and/or Maraviroc Did Not Affect HIV-1 Cell-Associated DNA, RNA, and 2­–LTR Circles Over 12 Weeks. Open Forum Infectious Diseases 2025, 12: ofaf594. PMID: 41141451, PMCID: PMC12548372, DOI: 10.1093/ofid/ofaf594.
      Peer-Reviewed Original Research
    • Cerebrospinal Fluid Immune Cell Alterations in Women With Neuropsychiatric Long COVID
      Orlinick B, Mehta S, McAlpine L, Khoshbakht S, Fertuzinhos S, Nelson A, Chiarella J, Das B, Patel V, Filippidis P, Corley M, Spudich S, Farhadian S. Cerebrospinal Fluid Immune Cell Alterations in Women With Neuropsychiatric Long COVID. Journal Of Infectious Diseases 2025, 233: e109-e117. PMID: 40920586, PMCID: PMC12811860, DOI: 10.1093/infdis/jiaf468.
      Peer-Reviewed Original Research
    • Olfactory Dysfunction After SARS-CoV-2 Infection in the RECOVER Adult Cohort
      Horwitz L, Becker J, Huang W, Akintonwa T, Hornig-Rohan M, Maranga G, Adams D, Albers M, Ayache M, Berry J, Brim H, Bryan T, Charney A, Clark R, Cortez M, D’Anza B, Davis H, Donohue S, Erdmann N, Flaherman V, Fong T, Frontera J, Goldberg M, Goldman J, Harkins M, Hodder S, Jacoby V, Jagannathan P, Jia X, Kelly J, Krishnan J, Kumar A, Laiyemo A, Levitan E, Martin J, McCaffrey K, McComsey G, Metz T, Murthy G, Nguyen H, Okumura M, Parry S, Parthasarathy S, Patterson T, Peluso M, Sorochinsky C, Walker T, Wiegand S, Wiley Z, Wisnivesky J, Ashktorab H, Foulkes A, Lee-Iannotti J, Han J, Marconi V, Ofotokun I, Patzer R, Walker T, Abraham R, Aguilar F, Ahmadi-Izad G, Ahmed D, Alvarez A, Anderson B, Asencios W, Beaty C, Bedi B, Berry J, Boone D, Bower M, Bremner J, Brent C, Brown-Smith K, Bull R, Capo G, Carl-Igwe K, Chitadze C, Chukwumerije N, Clyburn E, Collins S, Costello J, Couture G, Craft A, Cui X, del Rio C, Detelich J, Dixon C, Dow J, Doyle D, Elchommali J, Elsey I, Franks N, Gallini J, Gutter E, Harding J, Hernandez L, Holloway C, Ifejika C, Jasarevic R, Javia V, Jeter M, Joseph Y, Juarez M, Kirkpatrick C, Koumanelis A, Krishnan S, Leon J, Lew V, Maier C, Makkaoui N, Maroney M, Martin C, Mbogo L, McCaslin A, McIntyre J, Moanna A, Montoya M, Morales E, Moran C, Murray C, Nelson R, Nguyen T, Ojoawo B, Osinski E, Oviedo S, Paredes-Gaitan Y, Prude M, Ramakrishnan G, Rebolledo P, Roberts M, Robinson K, Rogers C, Rouphael N, Searles C, Segall M, Shah A, Silva R, Simpson C, Simpson-Derrell K, Sirajud-Deen T, Stroud J, Suthar M, Sylber C, Sylvera A, Teunis L, Thomas K, Titanji K, Toy C, Truong A, Vaccarino V, Varney K, Vyas K, Vyas K, Walkow M, Wesley T, Winston J, Winter T, Wongtrakool C, Cribbs S, Collins O, Fournier C, Francis A, Hang T, Ingram K, Lainez J, Rubinsztain L, Yeung H, Wiley Z, Ager A, Gray N, Grimes A, Gromer D, Hewitt L, Huerta C, Johnson B, Kelley C, Khalil L, Kleinhenz D, Koumanelis A, Kozoman R, Lee M, Lewis K, Litvack M, Maramba T, Mehta C, Panganiban B, Rahman K, Smith V, Stringer A, Tolbert M, Traenkner J, Unterberger K, Wang H, Wimberly E, Yang Q, Ryerson A, Hjortsberg R, Hudgins A, Martinez M, Neuman R, Thompson S, Agu C, Pemu P, Afani A, Ariri C, Dandy A, Harper K, Ibeawuchi C, Lawrence B, Morgan-Billingslea J, Ojemakinde E, Smith K, Levy B, Aikawa M, Baden L, Baslet G, Bennett L, Bhattacharyya S, Buring J, Cagnina R, Chen L, Clark C, Cohen P, Czeisler C, Estill P, Gay E, Hong J, Lamas D, Lay S, Levy-Carrick N, Manson J, Monafrared T, Redline S, Remis E, Schilkrut D, Sesso H, Solomon S, Sparks J, Spencer L, Systrom D, Thu P, Walt D, Washko G, Whittelsey M, Wiener R, Bassett I, Alba G, Aung T, Fitch K, Ginns L, Haas J, Hu Y, Juelg B, Kanjilal D, Kim A, Klerman E, Lewis G, Musa A, Ojikutu B, Perlis R, Rosand J, Wallace Z, Xerras D, Zionts D, Mullington J, Collier A, Fong T, Haack M, Hauser K, Maley J, Quintana Y, Shaughnessy L, Stephenson K, Thomas R, Torres R, Marathe J, Duffy E, Hamburg N, O'Connor G, Zhang H, John J, Ticotsky A, Ward H, Blazey-Martin D, Ghamloush M, Jordan M, Kogelman L, Marryshow T, Erdmann N, Levitan E, Tita A, Armstrong D, Binkley S, Blackwell K, Causey A, Cook F, Domingo J, Donahue C, Eady M, Edberg J, Forehand K, Frazier P, Garcia-McClaney N, Garner M, Gray B, Hall W, Hart C, Hebson C, Hidalgo B, Higgins B, Holtzapfel K, Horton G, Jinright A, Judd S, Kennedy T, Kirkwood L, Maier M, McCormack P, Mitchell K, Montgomery A, Nieters D, Peralta-Carcelen M, Pilco J, Powell L, Royster J, Shevin R, Skipworth S, Spurgeon L, Steele C, Vines J, Ware G, Wilson R, Woodruff D, Young B, Gillespie M, Daniel C, Hansel J, Wu J, Carton T, Miele L, Brown T, Sutherland E, Fuloria J, Datri P, Hagensee M, Leggio C, Perkins A, Trauth A, Trotter S, Van Deerlin A, Weiser S, Young M, Ashktorab H, Brim H, Laiyemo A, Sherif Z, Durrani S, Nezamloo A, Ngwa J, Njoku N, Gentil M, Mehari A, Solemani A, Chang L, Thuluvath P, Alemu M, Anderson J, Chauhan M, Cho S, Goodman K, Lanke G, Lebron R, Maheshwari A, Ok J, To C, Hodder S, Bardes J, Dominique-Villanueva D, Juskowich J, Reece R, Sarwari A, Shellito J, Greenway F, Kirwan J, Rodemann G, Rosen C, Arruda A, Brunet T, Emery I, Roelke T, Berger P, Black L, Hoover S, Tjarks B, Fonseca V, Gupta S, Longo M, Yang M, Shikuma C, Chow D, MarGangcuangco L, Castro M, Bengtson C, Howard T, Koontz B, Spikes L, Simmons C, Whiteheart S, Garvy B, Wood J, Marshall G, Garla V, Kuebler J, Nandi U, Vasey A, Warren D, Dickinson J, VanWagoner T, Bogie A, Heyanka D, James J, Scott J, Sukhera F, Luciano Roman C, Perez Frontera S, Santana Bagur J, Klein J, Krishnan J, Lin J, Muramatsu N, Prabhakar B, Prendergast H, Vanden Hoek T, Adams D, Baker A, Barbera S, Basu S, Bleasdale S, Boyd A, Breiter T, Buhimschi I, Carrithers M, Chalamalla R, Chestek D, Cook J, Darbar D, Dasgupta R, Davis Blakley F, DeLisa J, Diviak K, Donlon M, Dworkin M, Ellison A, Flanigan C, Freedman M, Gerald L, Giles W, Gordon H, Hammad B, Hasek S, Hasse W, Hryniewicka M, Illendula S, Ismail N, Jain A, Jennette K, Kadubek G, Kent D, Kent D, Kim K, Kotini-Shah P, Large L, Lash J, Lu J, Mahamed A, Malchenko S, Martinez M, Mauntel-Medici C, McCauley M, Menchaca M, Mermelstein R, Moreno D, Morrissy L, Musick H, Norwick L, Novak R, Ortiz M, Patel K, Perez N, Pliskin N, Pope S, Prasad B, Predki B, Quigley J, Ramchandran R, Ramirez A, Rappe S, Rehman J, Rowley M, Rudraraju G, Rutherfoord M, Sculley J, Smith-Mack J, Sun J, Tartt N, Villanueva L, Warfield Kelly S, Yazici C, Certa M, Chessier E, Everett E, Kindred E, Harris P, Sudhindra P, Olds L, Aponte-Soto L, Del Rios M, Diaz M, Ibanez A, Rolon C, Cranford S, Brown D, Dixon J, Gale L, Hammerl S, Hartwig K, Madineni A, Swearingen P, Hendrickson M, Noland S, Terlinde T, Hobbs B, Stewart de Ramirez S, Bolliger D, Boyineni J, Chebrolu P, Curry H, Donohue S, Edmonds S, Kelly S, Maholovich P, Sader S, Thompson T, Welter H, Woolley B, Hafner J, Hanson K, Hutton R, Charney A, Kovatch P, Merad M, Nadkarni G, Wisnivesky J, Aberg J, Ascolillo S, Bagiella E, Bartram L, Becker J, Beckmann N, Bendl A, Chen B, Civil A, Crawford G, Dhar K, Evo-Ortega L, Fierer D, Gallagher E, Garcia-Sastre A, Gnjatic S, Gray I, Guliyeva S, Harvey-Ingram L, Herrera-Moreno J, Hill M, Horowitz C, Jackson R, Kastrat D, Lala-Trindade A, Lin J, Macaluso N, Marcon K, Meyer D, Morinigo J, Natelson B, Nussenzweig M, Padua T, Putrino D, Richardson L, Russo S, Seifert A, Serri A, Walker J, Yee M, Bateman L, Hess R, Truong D, Alekhina N, Barlocker J, Brown J, Cortez M, Donohue D, Facelli J, Gouripeddi R, Hermansen J, Johnny J, Lindsay A, Lloyd J, Lu Y, Medina J, Morimoto S, Pace L, Rius D, Scholand M, Shah K, Sharareh N, Spivak A, Stringham C, Trinity J, Velinder M, Weaver L, West J, Vernon S, Deakyne Davies S, Gardner E, Buck K, Gonzalez Rivas E, Hawkins K, Oakes J, Sanchez Vazquez W, Horne B, Knowlton K, Woller S, Aguirre B, Anderson J, Bair T, Bosh L, Evans L, Garrett C, Harris D, Herrera K, Iverson L, Jensen M, Juan J, Knight S, Leither L, Maestas H, May H, Zubal S, Erlandson K, Sokol R, Brightman M, Davis D, Feuerriegel E, Fudge H, Garg L, Higgins J, Jolley S, Lockie T, McCandless S, Pitch C, Reusch J, Thurman B, Tran H, West S, Friedman N, Ludwig K, Decker L, Raissy H, Adolphi N, Archuleta D, Bradfute S, Brito R, Elifritz J, Garcia-Soberanez N, Gentry F, Harkins M, Martinez N, Montoya L, Parada A, Quinn D, Ramos A, Sheehan E, Treacher I, McComsey G, Adams C, Andrefsky J, Atieh O, Baissary J, Boldt N, Chemali K, Ciborek E, Conrad A, D’Anza B, Daher J, DiFrancesco K, Foster (Rodgers) T, Gallagher M, Gupta A, Harrill J, Harris P, Jacono F, Kelly J, Koberssy Z, Kumar R, Labbato D, Lim J, Pettinato K, Rodgers M, Rosolia B, Roy A, Sattiraju S, Scott S, Smith B, Tejani V, Tribout M, Yendewa G, Singer N, Ayache M, Barnboym E, Brown A, Chesnick H, Edminston M, Greenwood C, Haghiac M, Kaufman E, Lengu K, Lowenthal R, Malakooti S, Oleson C, Pearman A, Rizea A, Smith C, Washington M, Weinberger E, Heath J, Brennan C, Edmark R, Gutierrez V, Hadlock J, Li S, Magis A, McDonald C, Murray K, Rowen L, Yuan D, Chen P, Banitaba A, Caudill A, Chopra T, Dahlke L, Diaz M, Gudipudi L, Jackman S, Mattison B, Modes M, Nelson C, Nwafor C, Parimon T, Pascual E, Salinas N, Torbati S, Watson S, Tuttle K, Alicic R, Baxter J, Emerson S, Hood S, Kuykendall K, White S, Wilcox L, Goldman J, Algren H, Del Alcazar J, Duven A, Kaneko J, Kim C, Manner P, Mason C, Okada A, Poussier R, Satira R, Wallick J, Chu H, Elias-Warren A, Harteloo A, Logue J, McCaffrey K, Nguyen H, Nambiar A, Patterson T, Potter J, Salehi M, Sharma K, Verduzco-Gutierrez M, Anderson R, Arellanes A, Barajas R, Chauhan S, Clarke G, Farner C, Fischer M, Goldberg M, Hastings G, Heard P, Hernandez J, Herrera I, Infante E, Johnson H, Jones J, Kellogg D, Kraig E, Longoria L, Okafor E, Patterson J, Pinones A, Reeves W, Scholler I, Seshadri S, Shah P, Shah D, Smith M, Soileau B, Solis P, Stoebner C, Sullivan M, Taylor B, Tragus R, Tsevat J, Hasbani K, Saade G, Hernandez Martinez G, Recabarren C, Sharma K, Paredes C, Alvarado S, Kumar A, Maldonado Y, Utz P, Blish C, Go M, Jagannathan P, Singh U, Ahuja N, Blomkalns A, Bonilla H, Brotherton R, Clinton K, Dingankar V, Geng L, Haddad F, Jamero C, Jee K, Jia X, Khurana N, Miglis M, O'Conor E, Olszewski K, Pathak D, Quintero O, Saperia C, Scott J, Urdaneta A, Varkey M, Nikolich J, Parthasarathy S, Ernst K, Esquivel D, Harris D, Harris S, Hernandez M, Hsu H, James M, Karnafel M, Knox K, Koleski A, LaFleur B, Lambert B, LaRue S, Lutrick K, Merchant N, Morton C, Mosier J, Olorunnisola T, Peralta J, Pilling W, Pogreba-Brown K, Rischard F, Ryan L, Smith T, Snyder M, Subbian V, Suhr K, Reiman E, Lee-Iannotti J, Autry L, Beydoun H, Borwege S, Copeland J, DiLise-Russo M, Fadden S, Gomez I, Grischo G, Hartley W, Hillier L, Ismail H, Iusim S, Kala M, Kim D, Murthy G, Unzek S, Vadovicky S, Veres S, Bime C, Hansen L, Hughes T, Khalid S, Lieberman D, Soto F, Wilson C, Zapien A, Deeks S, Kelly J, Martin J, Peluso M, Anderson G, Anglin K, Argueta U, Asare K, Buitrago M, Chang Song C, Clark A, Conway E, Del Castillo N, Deswal M, Durstenfeld M, Eilkhani E, Eun A, Fehrman E, Figueroa T, Flores D, Grebe H, Henrich T, Hoh R, Hsue P, Huang B, Ibrahim R, Kerbleski M, Kirtikar R, Lew M, Lombardo J, Lopez M, Luna M, Marquez C, Munter S, Ngo L, Pineda-Ramirez J, Prather A, Rhoads K, Rodriguez A, Romero J, Ryder D, So M, Somsouk M, Tai V, Tran B, Uy J, Valdivieso D, Verma D, Williams M, Zamora A, Flaherman V, Jacoby V, Araya N, Arellano-Mechor C, Basi Y, Chang A, Christopher L, De La Torre I, Gade S, Guerreros E, Laleau V, Martin Herz S, Monzon V, Oceguera Barragan Y, Rait M, Salem M, Tolentino M, Metz T, Lamb D, Mcfarland E, Nelsen A, Phillips K, Schlater S, Sharma J, Sowles A, Valencia Vazquez J, Zaldivar M, Rouse D, Allard D, Beati L, DeMartino A, Lefebvre H, Milano J, Miller E, Hoffman M, Kitto C, Vanneman A, Reddy U, Bousleiman S, Eccheveri S, Gutierrez Y, Loffredo M, Perez A, Ravi R, Zork N, Hughes B, Ferrara J, Longo M, Mitchell M, Esplin M, Palatnik A, Karasti M, Peterson Z, Saffian E, Wiegand S, Fennig K, Snow E, Skupski D, Pao R, Patel R, Zaw H, Plunkett B, Anglemire K, Kapogiannis C, Kearns K, Suresh S, Yee L, Brinson M, Jones^ D, Kominiarek M, Mallett G, Reynolds T, Williams E, Palomares K, Beche I, Graziano-Carrete D, Perez C, Clifton R, Barrett K, Mullowney C, Sandoval G, Weiner S, Gibson K, Dalton W, Desantis B, Gill-Jones P, Pierse A, Polito L, Rosolowski B, Sweet E, Costantine M, Bartholomew A, Cackovic B, Dembroski C, Grobman W, Klopfenstein B, Mast D, McDaniel K, Paglione M, Rigsby C, Hackney^ D, Tita A, Armstrong D, Burrell N, Casey B, Dunn D, Mann M, Hoffman M, Docter O, Fischer L, Phipers J, Thorp J, Clark K, Leatherland M, Timlin S, Parry S, Filipczak A, Long E, McCabe M, Pizzi C, Simhan H, Bauer E, Boyce J, Facco F, Hankle S, Hines R, Hohn M, Muthukrishnan A, Sciurba F, Vargo J, Pacheco L, Cornwell J, DeVolder J, Nounes A, Salazar A, Thibodeaux L, Mendez-Figueroa H, Ortiz F, Rugerio J, Treadway J, Beamon C, Dufresne I, Grinnan C, Phillips H, Pettker C, Perley L, Rink L, Newman L, Abella J, Barnette Q, Bevc C, Beverly J, Ceger P, Croxford J, Cunningham E, Enger M, Fain K, Farris T, Hanlon S, Hines D, Johnson-Lawrence V, Jordan K, Lefebvre C, Linas B, Luukinen B, Mandal M, McKoy N, Nance S, Oakland A, Pasquarelli D, Quiner C, Sembajwe R, Shaw G, Thornburg V, Tosco K, Wright H, Gross R, Hochman J, Horwitz L, Katz S, Troxel A, Adler L, Akinbo P, Almenana R, Bello O, Bhuiyan S, Blachman N, Branski R, Briscoe J, Brosnahan S, Bueler E, Burgos Y, Caplin N, Chaplin D, Chen Y, Cheng S, Choe P, Choi J, Chung A, Church R, Cobos S, Croft N, Cruz Irving A, Del Boccio P, Díaz I, Doshi V, Ebel S, Faustin A, Febres E, Fine J, Fink S, Frontera J, Gallagher R, Gonzalez-Duarte A, Hasson D, Hill S, Islam S, Johnson S, Kansal N, Kenney R, Kewlani D, Lamendola-Essel M, Laynor G, Leon T, Lewczak Z, Linton J, Logan M, Malik N, Mamistvalova L, Mandel H, Maranga G, Mathews P, Mattoo A, Mei T, Mendelsohn A, Mercier E, Millar Vernetti P, Miller M, Mitchell M, Moreira A, Mudumbi P, Nahin E, Nair N, Nekulak J, Owens K, Parent B, Patibandla N, Petrov P, Postelnicu R, Randall I, Rao P, Rapkiewicz A, Rizzo J, Rosas J, Rose C, Saint-Jean C, Santacatterina M, Shah B, Shaukat A, Simon N, Simsir A, Stinson M, Tang W, Tatapudi V, Thawani S, Thomas M, Thorpe L, Tom M, Treiha E, Truong J, Udosen M, Velazquez-Perez J, Vernetti P, Vidal C, Viswanathan A, Wong C, Wood M, Wuller S, Yin S, Young C, Zaretsky J, Zavlunova S, Foulkes A, Karlson E, Murphy S, Ahirwar S, Ahmed S, Ainsworth L, Atchley-Challenner R, Avilach P, Balan T, Benik N, Benoit B, Bind M, Bonaventura W, Boutin N, Brion B, Cagan A, Cai T, Cao T, Castro V, Cerretani X, Chan J, Cheng D, Chibnik L, Ciriello M, Costenbader K, Dimitrov D, Estiri H, Fayad M, Feldman C, Gainer V, Ghosh B, Gollub R, Guan Z, Harris A, Helmer K, Hendrix A, Holzbach A, Huang W, Kaufman D, Keogh D, Kerr J, Klann J, Krishnamoorthy A, Lasky-Su J, Liao K, MacFadden D, Maram A, Martel M, Mendis M, Metta R, Monteiro J, Morales E, Morse R, Nazaire M, Neils G, Nguyen A, Norman J, Paik H, Pant D, Park H, Rabideau D, Reeder H, Rossi-Roh K, Santacroce L, Schlepphorst K, Schulte C, Selvaggi C, Shinnick D, Simons W, Simpson L, St. Jean Flanders M, Strasser Z, Thakrar M, Thaweethai T, Thorn M, Trewett P, Van Fleet D, Wagholikar K, Wang T, Wattanasin N, Weber G, Williams M, Zhang R, Cicek M, Flotte T, Boysen E, Chang N, Ellingworth E, Frisch E, Welch G, Yusuf A, Zahnle N, Cerda M, Clash V, Taylor B, Zissis M, Akintonwa T, Blancero F, Brown H, Carmilani M, Copeland D, Hall Y, kondo K, Lerma L, Lindsay J, Marti H, Maughan C, Minor T, Vincent H, Burns J, Spudich S, Bailey C, Cortez M, Foulkes A, Goff D, Lasky-Su J, Ofotokun I, Stockwell M, Stone J, Taylor B, Utz P, Williams N, Warburton D, Davis H, Erdmann N, Gage Witvliet M, Jain M, Martinez T, McGrath R, Rutter J, Bishof K, Dumitriu D, Goepfert P, Goldman S, Hewitt S, Huentelman M, Karp B, Lachowicz-Scroggins M, Nikolich-Zugich J, Perlowski A, Reeves B, Salazar J, Valantine H, Waldrop D, Anderson K, Aragon L, Azor-Sterlin M, Bander B, Basu L, Bolecek J, Burke C, Carignan E, Castro Baucom L, Chen H, Clash V, Cohen A, Cole S, Coombs K, Copeland V, Covington L, Cox W, Crawford S, Debrosse A, DeRosa R, Diggs M, Doster J, Douglas J, Dunn M, Edwards B, Evans L, Fisher L, Fisher K, Fitzgerald M, Fleming D, Gage Witliet M, Garbutt C, Ghormley T, Godwin T, Gressley A, Gustafson T, Hanlon W, Hassey T, Holmes V, Hornig M, Hornig M, Huff-Davis A, Jackson Love J, Jain N, Jones J, Kaleponi G, Karwowsky J, La Londe-Pinkston J, Lam J, Letts R, Lewis J, Lima J, Lindsay D, Martinez A, McCorkell L, McCray N, McNulty M, Nguyen K, Nichols L, Noriega E, Nunes P, O'Brien L, Ortiz G, Owen S, Page J, Peddie A, Phillips-Lorenzo E, Prentiss L, Raytselis N, Regino L, Rockwell M, Saldino R, Sapunar L, Savage S, Seibert E, Sekar A, Souder A, Spier E, Stanislawczyk M, Stein-Seroussi D, Sullivan C, Taylor E, Taylor K, Terry D, Wallace A, Warner J, White B, Wilensky R, Williams M, Williams N, Williams-Dawson K, Wylam A. Olfactory Dysfunction After SARS-CoV-2 Infection in the RECOVER Adult Cohort. JAMA Network Open 2025, 8: e2533815. PMID: 40996759, PMCID: PMC12464792, DOI: 10.1001/jamanetworkopen.2025.33815.
      Peer-Reviewed Original Research
    • Blood pressure and metabolic outcomes after efavirenz‐ or dolutegravir‐based therapy started in acute HIV infection
      Chan P, Moreland S, Sacdalan C, Colby D, Ocampo F, Promsena P, Sriplienchan S, Wattana J, Intasan J, Phanuphak N, Vasan S, Paul R, Trautmann L, Spudich S, Kroon E, Team T. Blood pressure and metabolic outcomes after efavirenz‐ or dolutegravir‐based therapy started in acute HIV infection. HIV Medicine 2025, 26: 1619-1625. PMID: 41047593, DOI: 10.1111/hiv.70085.
      Peer-Reviewed Original Research
    • Inside out: TNFa-RII and sexualized drug use in acute HIV predicts persistent depressive symptoms despite antiretroviral therapy
      Chavez J, Bolzenius J, Chan P, Cho K, Mannarino J, Sacdalan C, Farhadian S, Trautmann L, Ndhlovu L, Tipsuk S, Crowell T, Krebs S, Slike B, Suttichom D, Colby D, Phanuphak N, Kroon E, Vasan S, Sriplienchan S, Spudich S, Paul R, Carrico A. Inside out: TNFa-RII and sexualized drug use in acute HIV predicts persistent depressive symptoms despite antiretroviral therapy. Brain Behavior & Immunity - Health 2025, 48: 101079. PMID: 40808976, PMCID: PMC12345309, DOI: 10.1016/j.bbih.2025.101079.
      Peer-Reviewed Original Research
    • Characterizing Long COVID Symptoms During Early Childhood
      Gross R, Thaweethai T, Salisbury A, Kleinman L, Mohandas S, Rhee K, Snowden J, Tantisira K, Warburton D, Wood J, Kinser P, Milner J, Rosenzweig E, Irby K, Flaherman V, Karlson E, Chibnik L, Pant D, Krishnamoorthy A, Gallagher R, Lamendola-Essel M, Hasson D, Katz S, Yin S, Dreyer B, Blancero F, Carmilani M, Coombs K, Fitzgerald M, Letts R, Peddie A, Foulkes A, Stockwell M, Darden P, Dixon L, Evans D, Garbe C, Hobart-Porter L, Howard L, Hummel K, Krehbiel H, Spradlin H, Yount P, Adam G, Angal J, Barber M, Clark K, Dos Reis C, Freesemann M, Friedrich C, Hockett C, Johannsen R, Johnson-Vonk E, Kaiser C, Kruse A, Lang J, Lim P, McCoy M, Miller L, Petereit (Cerkovnik) S, RiChard (Werpy) J, Seiler J, Sundleaf B, Svendsen J, Trosper B, Vermeulen O, Young S, Dabney S, Fahrner M, Gallagher T, Martini K, McNally M, Vivensi Stiverson S, Balaraman V, Cheung J, Hong T, Kalua S, Minami E, Siu A, Tong M, Dantas M, Kasmarcak T, Milks K, Ikomi C, Meyer M, Nguyen C, Pellicciotti G, Phan T, Ravin K, 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Archuleta D, Brito R, Campbell R, Chavez J, Dehority W, Garcia-Soberanez N, Gronert E, Kadish M, Larrabee J, Lovato D, Luo K, Martinez N, Merlino A, Reese E, Ward S, Wilson K, Brown R, Butchee R, Fergeson G, McKee R, Mohler B, Moore T, Owens V, Stubbs S, VanWagoner T, Bethel M, Chassereau L, Lahiri T, Lake L, Moffett K, Polak E, Stutler S, Workman C, Carpenter E, Dhindsa I, Mejia S, Moghadam N, Mulder C, O'Neil S, Osornio A, Rios A, Rosen S, Smith A, Tabibi D, Tang S, Teame A, Stockwell M, Anderson B, Aquino T, Berg E, Caddle S, Catallozzi M, Chung W, Connors T, De A, Diaz Perez A, DiLorenzo M, Dumitriu D, Farooqi K, Fremed M, Goldman S, Kaplan K, Krishnan U, Layton A, Lignelli-Dipple A, McClaren S, Overdevest J, Rodriguez M, Selman J, Silver W, Silverio R, Valdez de Romero A, Vargas C, Caputo D, Leggieri C, Pretsch P, Davis K, Griffith M, Harris D, Macario E, Steffes J, Torres A, Day C, Howell K, Mains M, Bean E, DeFelice C, El Chebib H, Herbst K, Lesmes S, Santos M, Schulman N, Brooks-Greien A, Colin K, Juarez-Colunga A, Manning B, Shields J, York D, Griswold J, Lee D, Nowakowski A, Riordan M, Aamir R, Abuzahrieh M, Bangalore N, Brown A, Dalton W, Fortuna S, Minium J, Rosolowski B, Ahmed A, Braniecki S, Contreras M, Jain S, Kaseta S, Messer Z, Ramirez A, Singh A, WIlliams R, Akerlundh A, Akshoomoff N, Arroyo M, Barrientos W, Bhattacharjee R, Chao B, Diaz M, Garcia S, Garcia S, Gomez G, Herrera T, Holguin M, Khare M, Kiernan E, Landeo Gutierrez J, Matta I, Reyes S, Ryu J, Sanchez C, Schreck A, Warner M, Cerracchio L, Folnagy A, Gzemski S, Hao Y, Li S, Moroso S, Ness-Cochinwala M, Patel A, Richlin B, Sharma H, Soto D, Suarez C, Vargas Forero B, Ricciardi E, Trespalacios V, Kluko M, Rhee K, Tantisira K, Acosta Valle D, Chao B, Choudhary A, Glenn-Arroyo M, Kiernan E, Landeo-Gutierrez J, Madan A, McConnaughey K, Ramos Vallejo L, Sanchez C, Suarez M, Caldas S, Castro Ovalle T, Chung A, Farkas J, Isidoro-Chino M, Kesebir D, Kim E, Quarless A, Schlechter A, Srinivasan R, Barry F, Burton P, Cano Lorente R, Cummins C, Wehbe S, Espinoza J, Moyer S, Rider A, Russell S, Schecter M, Stevenson L, Burns J, Spudich S, Bailey C, Cicek M, Cortez M, Davis Blakley F, Goff D, Lasky-Su J, Newman L, Ofotokun I, Seshadri S, Stone J, Taylor B, Utz P, Williams N, Abella J, Barnette Q, Bevc C, Beverly J, Ceger P, Croxford J, Cunningham E, Enger M, Fain K, Farris T, Hanlon S, Hines D, Johnson-Lawrence V, Jordan K, Lefebvre C, Linas B, Luukinen B, Mandal M, McKoy N, Nance S, Oakland A, Pasquarelli D, Quiner C, Sembajwe R, Shaw G, Thornburg V, Tosco K, Wright H, Hochman J, Horwitz L, Katz S, Troxel A, Adler L, Akinbo P, Almenana R, Bello O, Bhuiyan S, Blachman N, Branski R, Briscoe J, Brosnahan S, Bueler E, Burgos Y, Caplin N, Chaplin D, Chen Y, Cheng S, Choe P, Choi J, Chung A, Church R, Cobos S, Croft N, Cruz Irving A, Del Boccio P, Díaz I, Doshi V, Ebel S, Faustin A, Febres E, Fine J, Fink S, Frontera J, Gonzalez-Duarte A, Hill S, Islam S, Johnson S, Kansal 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Hendrix A, Holzbach A, Huang W, Kaufman D, Keogh D, Kerr J, Klann J, Lasky-Su J, Liao K, MacFadden D, Maram A, Martel M, Mendis M, Metta R, Monteiro J, Morales E, Nazaire M, Neils G, Norman J, Paik H, Park H, Qian Z, Rossi-Roh K, Santacroce L, Selvaggi C, Simons W, Simpson L, Strasser Z, Tariq A, Thorn M, Trewett P, Van Fleet D, Wagholikar K, Wang H, Wang T, Wattanasin N, Weber G, Williams M, Flotte T, Boysen E, Chang N, Ellingworth E, Frisch E, Welch G, Yusuf A, Zahnle N, Cerda M, Clash V, Taylor B, Zissis M, Akintonwa T, Brown H, Copeland D, Hall Y, kondo K, Lerma L, Lindsay J, Marti H, Maughan C, Minor T, Vincent H, Blomkalns A, Bassett I, Clifton R, Davis H, Erdmann N, Gage Witvliet M, Goldberg M, Guan Z, Jain M, Klein J, Martinez T, McGrath R, Parthasarathy S, Pemu P, Rutter J, Aschner J, Atz A, Banerjee D, Bogie A, Bukulmez H, Clouser K, Cottrell L, Cowan K, D’Sa V, Dozor A, Elliott A, Faustino E, Fiks A, Gaur S, Gennaro M, Gordon S, Hasan U, Hester C, Hogan A, Hsia D, Kaelber D, Kosut J, Krishnan S, McCulloh R, Michelow I, Nolan S, Oliveira C, Olson L, Pace W, Palumbo P, Raissy H, Reyes A, Ross J, Salazar J, Selvarangan R, Stein C, Stevenson M, Teufel R, Werzberger A, Westfall J, Zani K, Zempsky W, Zimmerman E, Bind M, Chan J, Guan Z, Morse R, Reeder H, Metz T, Newburger J, Truong D. 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      Investigations in CNS HIV Reservoirs and HIV Cure

      01/01/2013 - PresentResearch
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      Effects of Acute HIV Infection in the Central Nervous System

      01/01/2011 - PresentResearch

    Clinical Care

    Overview

    Serena Spudich, MD, MA, is one of only a few neurologists in the United States with specialized training in infections of the nervous system and a clinical practice focusing on neurological issues in patients with HIV.

    She primarily cares for patients with HIV who suffer from such neurological problems as cognitive disturbances, memory loss and infections. “Many of these are directly related to HIV,” she says. In addition, she consults with patients who have such infections of the nervous system as Lyme disease and West Nile virus, and those with general neurological disorders.

    A professor of neurology at Yale School of Medicine and division chief of neurological infections and global neurology, Dr. Spudich strongly believes patients can lead longer and healthier lives when HIV is diagnosed and treated early. “The example that one patient has proven to be cured of HIV, which was previously thought to be an ‘incurable’ disease, brings hope to the 37 million people worldwide infected with HIV, and to those with other chronic infections that impact the brain,” she says.

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    Neurology; HIV & AIDs Medicine; Infectious Diseases

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    • Neuroinfectious Disease Research Program

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      135 College Street, Fl 3

      New Haven, CT 06510

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