2014
Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA
Rongvaux A, Jackson R, Harman CC, Li T, West AP, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan CY, Taniguchi T, Shadel GS, Chen ZJ, Iwasaki A, Flavell RA. Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA. Cell 2014, 159: 1563-1577. PMID: 25525875, PMCID: PMC4272443, DOI: 10.1016/j.cell.2014.11.037.Peer-Reviewed Original ResearchConceptsMitochondrial outer membrane permeabilizationCell deathOuter membrane permeabilizationType I interferonDNA-dependent activationCaspase-dependent mannerI interferonCGAS/STING pathwayMitochondrial DNAApoptotic caspasesMembrane permeabilizationActive caspasesProapoptotic caspasesMitochondriaCaspasesSTING pathwayIFN responseAntiviral immunityCentral roleDual controlPathwayProinflammatory typeInductionCellsActivation
2012
JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation
Han MS, Jung DY, Morel C, Lakhani SA, Kim JK, Flavell RA, Davis RJ. JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation. Science 2012, 339: 218-222. PMID: 23223452, PMCID: PMC3835653, DOI: 10.1126/science.1227568.Peer-Reviewed Original ResearchConceptsInsulin resistanceObesity-induced insulin resistancePro-inflammatory macrophage polarizationProtection of miceHigh-fat dietJNK-deficient miceMacrophage polarizationSimilar obesityTissue infiltrationInflammationMacrophagesMiceJNK deficiencyJNK expressionMetabolic responseRole of JNKObesityTerminal kinaseJNK