JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation
Han MS, Jung DY, Morel C, Lakhani SA, Kim JK, Flavell RA, Davis RJ. JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation. Science 2012, 339: 218-222. PMID: 23223452, PMCID: PMC3835653, DOI: 10.1126/science.1227568.Peer-Reviewed Original ResearchConceptsInsulin resistanceObesity-induced insulin resistancePro-inflammatory macrophage polarizationProtection of miceHigh-fat dietJNK-deficient miceMacrophage polarizationSimilar obesityTissue infiltrationInflammationMacrophagesMiceJNK deficiencyJNK expressionMetabolic responseRole of JNKObesityTerminal kinaseJNK