Featured Publications
Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea
Zinchuk AV, Jeon S, Koo BB, Yan X, Bravata DM, Qin L, Selim BJ, Strohl KP, Redeker NS, Concato J, Yaggi HK. Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea. Thorax 2017, 73: 472. PMID: 28935698, PMCID: PMC6693344, DOI: 10.1136/thoraxjnl-2017-210431.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedCardiovascular DiseasesCluster AnalysisCross-Sectional StudiesFemaleHumansIschemic Attack, TransientLongitudinal StudiesMaleMiddle AgedMortalityPhenotypePolysomnographyProportional Hazards ModelsRisk AssessmentSeverity of Illness IndexSleep Apnea, ObstructiveStrokeConceptsObstructive sleep apnoeaCardiovascular outcomesPolysomnographic featuresSleep apnoeaPolysomnographic dataIncident transient ischemic attackUS Veteran cohortTransient ischemic attackAcute coronary syndromeAdverse cardiovascular outcomesPeriodic limb movementsOSA severity classificationPolysomnographic phenotypeCoronary syndromeIschemic attackCardiovascular implicationsOSA phenotypesOSA evaluationPathophysiological domainsPoor sleepMild/Patient clustersVeteran cohortSurvival analysisCombined outcome
2024
Association of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality
Zinchuk A, Srivali N, Qin L, Jeon S, Ibrahim A, Sands S, Koo B, Yaggi H. Association of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality. Journal Of The American Heart Association 2024, 13: e031630. PMID: 38240208, PMCID: PMC11056155, DOI: 10.1161/jaha.123.031630.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesHumansNocturnal Myoclonus SyndromePolysomnographySleepSleep Apnea, ObstructiveConceptsPeriodic limb movement indexApnea-hypopnea indexObstructive sleep apneaPeriodic limb movementsSleep apneaIncident cardiovascular diseasePrimary outcomeCardiovascular diseaseAssociation of apnea-hypopnea indexIncreased risk of primary outcomeIncreased riskRisk factorsRisk of primary outcomeAssociated with primary outcomeMedian follow-upBaseline risk of mortalityCox proportional hazards regressionRisk of cardiovascular diseaseLimb movement indexCharlson Comorbidity IndexFramingham risk scoreProportional hazards regressionRisk of mortalityCardiovascular disease eventsFollow-up
2017
The Yale Fitness Intervention Trial in female cancer survivors: Cardiovascular and physiological outcomes
Knobf MT, Jeon S, Smith B, Harris L, Thompson S, Stacy MR, Insogna K, Sinusas AJ. The Yale Fitness Intervention Trial in female cancer survivors: Cardiovascular and physiological outcomes. Heart & Lung 2017, 46: 375-381. PMID: 28803675, PMCID: PMC6129386, DOI: 10.1016/j.hrtlng.2017.06.001.Peer-Reviewed Original ResearchConceptsFemale cancer survivorsCancer survivorsCenter interventionMET-minutes/weekStable insulin levelsMetabolic risk factorsResistance exercise programExercise stress testCardiovascular disease riskPhysical activity groupImproved insulin resistanceHeart rate recoveryMinutes/weekRisk reduction interventionsMajority of subjectsAdjuvant chemotherapyPremature menopauseExercise programInsulin levelsInsulin resistanceIntervention trialsRisk factorsCardiovascular functionBreast cancerRate recovery