The Utility of Screening in the Design of Trials for Symptom Management in Cancer
Jeon S, Given CW, Sikorskii A, Given B. The Utility of Screening in the Design of Trials for Symptom Management in Cancer. Journal Of Pain And Symptom Management 2009, 38: 606-614. PMID: 19699052, PMCID: PMC2761530, DOI: 10.1016/j.jpainsymman.2009.02.233.Peer-Reviewed Original ResearchConceptsSymptom managementIntervention contactsSeverity scoreClinical trialsCancer symptom management trialsLikelihood ratioUtility of screeningSeverity of symptomsDesign of trialsSymptom management trialsPost-test probabilityReceipt of interventionTrial entryCancer patientsPatientsTrial designSymptomsDiscriminative accuracyRating ScaleTrialsSeverityCharacteristic curveManagement trialsCancerInterventionResponse analysis for multiple symptoms revealed differences between arms of a symptom management trial
Sikorskii A, Given CW, You M, Jeon S, Given BA. Response analysis for multiple symptoms revealed differences between arms of a symptom management trial. Journal Of Clinical Epidemiology 2009, 62: 716-724. PMID: 19124223, PMCID: PMC2743381, DOI: 10.1016/j.jclinepi.2008.09.007.Peer-Reviewed Original ResearchConceptsSymptom management trialsIntervention contactsMultiple symptomsCancer-related symptomsProportional hazards modelManagement trialsScore of severityCancer painClinical improvementPoor appetiteSymptom managementCognitive-behavioral interventionsDisease characteristicsCancer patientsHazards modelPatientsSymptomsStudy designTrialsSeverityGood responseMarginal proportional hazards modelInterventionArmResponse