2024
Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival
Zaman S, Gorelick F, Chrobrutskiy A, Chobrutskiy B, Desir G, Blanck G. Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival. Oncotarget 2024, 15: 550-561. PMID: 39102218, PMCID: PMC11299663, DOI: 10.18632/oncotarget.28633.Peer-Reviewed Original ResearchConceptsT cell receptorOverall survivalT cellsAssociated with improved overall survivalT-cell receptor CDR3sPromote T cell activationImproved overall survivalSurvival of melanomaPancreatic cancer patientsT cell activationT cell receptor recognitionTumor-residentTumor rejectionMelanoma patientsMelanoma growthMelanoma survivalImmune signature genesSurvival associationsCancer patientsMelanomaSignature genesAmino acid sequenceSurvivalPatientsExpression levels
2023
Bacterial Sequencing Reads in Blood Exome Files from Melanoma and Cervical Cancer Patients are Associated with Cancer Recurrence
Quach J, Diaz M, Huda T, Kinskey J, Zaman S, Desantis J, Cios K, Blanck G. Bacterial Sequencing Reads in Blood Exome Files from Melanoma and Cervical Cancer Patients are Associated with Cancer Recurrence. Molecular Biotechnology 2023, 65: 1476-1484. PMID: 36653589, DOI: 10.1007/s12033-023-00663-9.Peer-Reviewed Original ResearchConceptsCervical cancer casesCervical cancer patientsCancer patientsExome filesCancer recurrenceCancer casesDisease-free survival probabilityImmunocompromised Cancer PatientsOverall survival resultsCancer clinical outcomesBacterial blood infectionsLower DFSClinical outcomesCervical cancerPrimary tumorSurvival resultsMelanoma casesBlood infectionSolid tumorsGreater riskPatientsBacteroides fragilisBloodPresence of bacteriaBacteroides species
2020
MP14-03 DENSITY OF T-BET POSITIVE T LYMPHOCYTES WITHIN THE TUMOR MICROENVIRONMENT IS ASSOCIATED WITH A FAVORABLE RESPONSE TO IMMUNOTHERAPY IN PATIENTS WITH METASTATIC RENAL CELL CARCINOMA
Hajiran* A, Aydin A, Kim Y, Zemp L, McCarthy S, Segura C, Nguyen J, Falasiri S, Zaman S, Spiess P, Kohli M, Mulé J, Manley B. MP14-03 DENSITY OF T-BET POSITIVE T LYMPHOCYTES WITHIN THE TUMOR MICROENVIRONMENT IS ASSOCIATED WITH A FAVORABLE RESPONSE TO IMMUNOTHERAPY IN PATIENTS WITH METASTATIC RENAL CELL CARCINOMA. Journal Of Urology 2020, 203 DOI: 10.1097/ju.0000000000000839.03.Peer-Reviewed Original ResearchPD39-06 POOR RESPONSE TO IMMUNOTHERAPY IS ASSOCIATED WITH HIGH EXPRESSION OF A NOVEL EPIDERMAL GROWTH FACTOR RECEPTOR SPLICE VARIANT IN PATIENTS WITH RENAL CELL CARCINOMA
Hajiran* A, Kim Y, Zaman S, Madanyake T, Robinson T, Falasiri S, Spiess P, Kohli M, Boyle T, Mulé J, Teer J, Manley B. PD39-06 POOR RESPONSE TO IMMUNOTHERAPY IS ASSOCIATED WITH HIGH EXPRESSION OF A NOVEL EPIDERMAL GROWTH FACTOR RECEPTOR SPLICE VARIANT IN PATIENTS WITH RENAL CELL CARCINOMA. Journal Of Urology 2020, 203 DOI: 10.1097/ju.0000000000000918.06.Peer-Reviewed Original Research
2019
MP71-03 COMPARISON OF NOVEL DNA-BASED TOOLS FOR BACTERIAL DETECTION IN PATIENTS WITH CHRONIC URINARY TRACT INFECTION (CUTI)
Coba G, Koo T, Zaman S, Stefil M, Dixon M, Ni L, McDonald M, Mouraviev* V. MP71-03 COMPARISON OF NOVEL DNA-BASED TOOLS FOR BACTERIAL DETECTION IN PATIENTS WITH CHRONIC URINARY TRACT INFECTION (CUTI). Journal Of Urology 2019, 201 DOI: 10.1097/01.ju.0000557115.69479.1b.Peer-Reviewed Original ResearchAn age-based, RNA expression paradigm for survival biomarker identification for pediatric neuroblastoma and acute lymphoblastic leukemia
Diviney A, Chobrutskiy BI, Zaman S, Blanck G. An age-based, RNA expression paradigm for survival biomarker identification for pediatric neuroblastoma and acute lymphoblastic leukemia. Cancer Cell International 2019, 19: 73. PMID: 30962767, PMCID: PMC6438000, DOI: 10.1186/s12935-019-0790-5.Peer-Reviewed Original ResearchAcute lymphoblastic leukemiaOlder diagnostic ageDiagnostic agePediatric neuroblastomaLymphoblastic leukemiaPrevalent pediatric cancerCancer survival ratesAge of diagnosisYounger patientsSurvival differencesPediatric cancerHigh levelsPatientsNeuroblastomaSurvival rateGene expression markersAgeExpression markersLeukemiaSurvival metricsBiomarker identificationLevelsCancerDiseaseGenes
2018
T-cell receptor-α CDR3 domain chemical features correlate with survival rates in bladder cancer
Chobrutskiy BI, Zaman S, Diviney A, Mihyu MM, Blanck G. T-cell receptor-α CDR3 domain chemical features correlate with survival rates in bladder cancer. Journal Of Cancer Research And Clinical Oncology 2018, 145: 615-623. PMID: 30539280, DOI: 10.1007/s00432-018-2815-1.Peer-Reviewed Original ResearchConceptsTumor-infiltrating lymphocytesT cell responsesBladder tumor tissuesT-cell featuresEx vivo amplificationT cell receptorBladder cancerCancer findingsFavorable outcomeCancer settingBetter outcomesSurvival rateTumor tissueCancerDriver mutationsImmunotherapyBiochemical featuresBioinformatics assessmentOutcomesAntigen bindingRegion 3TILsPatientsLymphocytesTherapyMMP7 sensitivity of mutant ECM proteins: An indicator of melanoma survival rates and T-cell infiltration
Zaman S, Chobrutskiy BI, Patel JS, Callahan BM, Tong WL, Mihyu MM, Blanck G. MMP7 sensitivity of mutant ECM proteins: An indicator of melanoma survival rates and T-cell infiltration. Clinical Biochemistry 2018, 63: 85-91. PMID: 30414845, DOI: 10.1016/j.clinbiochem.2018.11.004.Peer-Reviewed Original ResearchConceptsMutant amino acidsT-cell infiltratesT cell infiltrationMelanoma survival ratesDistinct survival outcomesCancer Genome AtlasSurvival outcomesWorse outcomesImmune activitySurvival rateMelanoma specimensMelanomaGenome AtlasPatientsAmino acidsOverall mutationsDetection of melanomaOutcomesOnly decreaseClinical Observation of Improved Outcomes of Patients With BRCA 1/2 Breast Cancer Treated With Everolimus Prior to DNA-Damaging Therapy.
Anderson M, Denson A, Zaman S, Han H, Soliman H. Clinical Observation of Improved Outcomes of Patients With BRCA 1/2 Breast Cancer Treated With Everolimus Prior to DNA-Damaging Therapy. JCO Precision Oncology 2018, 2: 1-5. PMID: 35135142, DOI: 10.1200/po.18.00123.Peer-Reviewed Original Research