2020
120-LB: Small Molecule Activator of Pyruvate Kinase Regulates In Vivo Glucose Homeostasis
ABULIZI A, CARDONE R, SIEBEL S, KUNG C, KIBBEY R. 120-LB: Small Molecule Activator of Pyruvate Kinase Regulates In Vivo Glucose Homeostasis. Diabetes 2020, 69 DOI: 10.2337/db20-120-lb.Peer-Reviewed Original ResearchEndogenous glucose productionNonalcoholic fatty liver diseaseWhole-body insulin sensitivityHFD-fed ratsInsulin sensitivityAgios PharmaceuticalsRegular chowInsulin resistanceBody weightInsulin-stimulated peripheral glucose uptakeGlucose productionHigh-fat diet ratsHyperinsulinemic-euglycemic clamp studiesSmall molecule activatorsMuscle triglyceride contentSevere liver dysfunctionFatty liver diseasePeripheral insulin sensitivityAmerican Diabetes AssociationWhole-body energy expenditurePeripheral glucose uptakeHigh-fat dietType 2 diabetesFat diet ratsPotential therapeutic target
2019
Mitochondrial Proton Leak Regulated by Cyclophilin D Elevates Insulin Secretion in Islets at Nonstimulatory Glucose Levels
Taddeo EP, Alsabeeh N, Baghdasarian S, Wikstrom JD, Ritou E, Sereda S, Erion K, Li J, Stiles L, Abdulla M, Swanson Z, Wilhelm J, Bellin MD, Kibbey RG, Liesa M, Shirihai O. Mitochondrial Proton Leak Regulated by Cyclophilin D Elevates Insulin Secretion in Islets at Nonstimulatory Glucose Levels. Diabetes 2019, 69: 131-145. PMID: 31740442, PMCID: PMC6971491, DOI: 10.2337/db19-0379.Peer-Reviewed Original ResearchConceptsType 2 diabetesInsulin secretionInsulin resistanceFree fatty acidsNonesterified free fatty acidsGlucose-stimulated insulin secretionPrediabetic stateInsulin hypersecretionObese subjectsFatty acidsObese miceLean miceGlucose levelsHuman isletsPancreatic isletsΒ-cellsIsletsProton leakSecretionHyperinsulinemiaProgressive increaseDiabetesMiceMitochondrial proton leakLeakChildhood Pancreatitis and Risk for Incident Diabetes in Adulthood
Bendor CD, Bardugo A, Zucker I, Cukierman-Yaffe T, Lutski M, Derazne E, Shohat T, Mosenzon O, Tzur D, Sapir A, Pinhas-Hamiel O, Kibbey RG, Raz I, Afek A, Gerstein HC, Tirosh A, Twig G. Childhood Pancreatitis and Risk for Incident Diabetes in Adulthood. Diabetes Care 2019, 43: 145-151. PMID: 31694859, PMCID: PMC7011197, DOI: 10.2337/dc19-1562.Peer-Reviewed Original ResearchConceptsIsraeli National Diabetes RegistryIncident diabetesAcute pancreatitisNormal pancreatic functionUnexposed groupPancreatic functionOdds ratioChildhood pancreatitisIncident type 2 diabetesNational Diabetes RegistryPopulation-based studyType 2 diabetesDiagnosis of diabetesLogistic regression analysisYears of ageBaseline BMINormal BMIDiabetes RegistryRisk factorsPancreatitisCase subjectsSociodemographic confoundersDiabetesYounger ageFurther adjustment