1999
Sustained Mitogen-activated Protein Kinase (MAPK) and Cytoplasmic Phospholipase A2 Activation by Macrophage Migration Inhibitory Factor (MIF) REGULATORY ROLE IN CELL PROLIFERATION AND GLUCOCORTICOID ACTION*
Mitchell R, Metz C, Peng T, Bucala R. Sustained Mitogen-activated Protein Kinase (MAPK) and Cytoplasmic Phospholipase A2 Activation by Macrophage Migration Inhibitory Factor (MIF) REGULATORY ROLE IN CELL PROLIFERATION AND GLUCOCORTICOID ACTION*. Journal Of Biological Chemistry 1999, 274: 18100-18106. PMID: 10364264, DOI: 10.1074/jbc.274.25.18100.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorPhospholipase A2 activityGlucocorticoid actionRole of MIFRecombinant macrophage migration inhibitory factorMitogen-activated protein kinaseImportant pro-inflammatory mediatorsA2 activityCytosolic phospholipase A2 activityPro-inflammatory mediatorsMigration inhibitory factorPro-inflammatory stimuliImmune cell activationCytoplasmic phospholipase A2Phospholipase A2 activationArachidonic acid releaseGlucocorticoid suppressionERK-dependent pathwayMIF actionInflammatory propertiesInflammatory responseExtracellular signal-regulated mitogen-activated protein kinaseCell activationInhibitory factorA2 activation
1995
Localization of Macrophage Migration Inhibitory Factor (MIF) to Secretory Granules within the Corticotrophic and Thyrotrophic Cells of the Pituitary Gland
Nishino T, Bernhagen J, Shiiki H, Calandra T, Dohi K, Bucala R. Localization of Macrophage Migration Inhibitory Factor (MIF) to Secretory Granules within the Corticotrophic and Thyrotrophic Cells of the Pituitary Gland. Molecular Medicine 1995, 1: 781-788. PMID: 8612200, PMCID: PMC2230018, DOI: 10.1007/bf03401892.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorRelease of MIFCorticotropin-releasing hormoneMigration inhibitory factorAnterior pituitary glandPituitary glandThyrotrophic cellsBackgroundMacrophage migration inhibitory factorInhibitory factorCorticotrophic cellsAnterior pituitary hormonesActivated T lymphocytesHormone-specific antibodiesSubsets of granulesGlucocorticoid suppressionSeptic shockLPS injectionCytokine productionEndotoxin administrationACTH releaseT lymphocytesConclusionsThese dataPituitary hormonesPituitary contentHost response