2020
Longitudinal analyses reveal immunological misfiring in severe COVID-19
Lucas C, Wong P, Klein J, Castro TBR, Silva J, Sundaram M, Ellingson MK, Mao T, Oh JE, Israelow B, Takahashi T, Tokuyama M, Lu P, Venkataraman A, Park A, Mohanty S, Wang H, Wyllie AL, Vogels CBF, Earnest R, Lapidus S, Ott IM, Moore AJ, Muenker MC, Fournier JB, Campbell M, Odio CD, Casanovas-Massana A, Herbst R, Shaw A, Medzhitov R, Schulz W, Grubaugh N, Dela Cruz C, Farhadian S, Ko A, Omer S, Iwasaki A. Longitudinal analyses reveal immunological misfiring in severe COVID-19. Nature 2020, 584: 463-469. PMID: 32717743, PMCID: PMC7477538, DOI: 10.1038/s41586-020-2588-y.Peer-Reviewed Original ResearchConceptsSevere COVID-19Moderate COVID-19Immune signaturesDisease outcomeCOVID-19Disease trajectoriesInterleukin-5Early immune signaturesInnate cell lineagesType 2 effectorsT cell numbersPoor clinical outcomeWorse disease outcomesImmune response profileCoronavirus disease 2019Distinct disease trajectoriesCytokine levelsImmunological correlatesImmune profileClinical outcomesEarly elevationImmune profilingIL-13Immunoglobulin EDisease 2019
2019
The Potential Population-Level Impact of Different Gonorrhea Screening Strategies in Baltimore and San Francisco: An Exploratory Mathematical Modeling Analysis
Rönn M, Testa C, Tuite A, Chesson H, Gift T, Schumacher C, Williford S, Zhu L, Bellerose M, Earnest R, Malyuta Y, Hsu K, Salomon J, Menzies N. The Potential Population-Level Impact of Different Gonorrhea Screening Strategies in Baltimore and San Francisco: An Exploratory Mathematical Modeling Analysis. Sexually Transmitted Diseases 2019, 47: 143-150. PMID: 31842089, PMCID: PMC7012354, DOI: 10.1097/olq.0000000000001108.Peer-Reviewed Original ResearchConceptsAnnual screeningMost infectionsHigh-burden areasAdditional screening testFocused intervention strategiesCompartmental transmission modelRace/ethnicityPotential population-level impactCare cascadeBurden areasAcquisition riskScreen populationsScreening testPopulation-level impactInfectionSan FranciscoSurveillance dataPrevalence distributionScreening strategyInterventionIntervention strategiesSuch interventionsGonorrheaTime trendsMathematical modeling analysis