2014
Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia
Brennand K, Savas J, Kim Y, Tran N, Simone A, Hashimoto-Torii K, Beaumont K, Kim H, Topol A, Ladran I, Abdelrahim M, Matikainen-Ankney B, Chao S, Mrksich M, Rakic P, Fang G, Zhang B, Yates J, Gage F. Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. Molecular Psychiatry 2014, 20: 361-368. PMID: 24686136, PMCID: PMC4182344, DOI: 10.1038/mp.2014.22.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntipsychotic AgentsCell DifferentiationCell MovementCells, CulturedFemaleGene ExpressionHumansMaleMiceMice, Inbred C57BLMice, TransgenicMitochondriaNeural Cell Adhesion MoleculesNeural Stem CellsOxidative StressPhenotypePluripotent Stem CellsProsencephalonProteomicsReactive Oxygen SpeciesSchizophreniaYoung AdultConceptsHiPSC neural progenitor cellsNeural progenitor cellsHuman-induced pluripotent stem cellsHiPSC-derived neuronsGene expressionGene expression comparisonsStable isotope labelingProteomic mass spectrometry analysisAbnormal gene expressionPluripotent stem cellsOxidative stressCytoskeletal remodelingMass spectrometry analysisCellular phenotypesExpression comparisonsDevelopmental mechanismsIsotope labelingPhenotypic differencesBrainSpan AtlasDisease predispositionAmino acidsScalable assayNPC phenotypeStem cellsProgenitor cells
2001
Requirement of the JIP1 scaffold protein for stress-induced JNK activation
Whitmarsh A, Kuan C, Kennedy N, Kelkar N, Haydar T, Mordes J, Appel M, Rossini A, Jones S, Flavell R, Rakic P, Davis R. Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Genes & Development 2001, 15: 2421-2432. PMID: 11562351, PMCID: PMC312784, DOI: 10.1101/gad.922801.Peer-Reviewed Original ResearchConceptsJIP1 scaffold proteinSignal transduction pathwaysScaffold proteinTransduction pathwaysMAP kinase signal transduction pathwayJNK activationStress-induced JNK activationKinase signal transduction pathwayC-Jun N-terminal kinase (JNK) signal transduction pathwayExposure of cellsHomologous recombinationEnvironmental stressPrimary hippocampal neuronsC-JunAnoxic stressJIP1ProteinPathwayJNKExcitotoxic stressHippocampal neuronsActivationGenesStressCritical component
1997
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
Yang D, Kuan C, Whitmarsh A, Rinócn M, Zheng T, Davis R, Rakic P, Flavell R. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 1997, 389: 865-870. PMID: 9349820, DOI: 10.1038/39899.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisDrug ResistanceExcitatory Amino Acid AgonistsGene ExpressionGene TargetingGlutamic AcidHippocampusKainic AcidMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 10Mitogen-Activated Protein KinasesNeuronsPhosphorylationProtein KinasesProtein Serine-Threonine KinasesProtein-Tyrosine KinasesProto-Oncogene Proteins c-fosProto-Oncogene Proteins c-junSeizuresSignal TransductionTranscription Factor AP-1ConceptsKainic acidGlutamate receptor agonist kainic acidAgonist kainic acidExcitotoxicity-induced apoptosisExcitatory amino acidsHippocampal neuron apoptosisHippocampus of miceStress-induced neuronal apoptosisObserved neuroprotectionGlutamate neurotoxicitySeizure activityNeuron apoptosisGlutamate toxicityNeuronal apoptosisAP-1 transcription factor complexJNK3 geneMutant miceMiceMembrane depolarizationNoxious stressTranscription factor complexApoptosisC-JunRecent studiesTranscriptional activityRestrictive clonal allocation in the chimeric mouse brain
Kuan C, Elliott E, Flavell R, Rakic P. Restrictive clonal allocation in the chimeric mouse brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 3374-3379. PMID: 9096401, PMCID: PMC20377, DOI: 10.1073/pnas.94.7.3374.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCell LineageChimeraClone CellsEmbryo, MammalianMiceMice, Inbred C57BLPolymerase Chain ReactionStem CellsConceptsBrain regionsChimeric mouse brainsMammalian cerebral cortexDifferent brain regionsCerebral cortexCerebral neocortexChimeric miceMouse brainChimeric brainsMammalian brainProgenitor cellsBrainClones of cellsNeocortexStem cellsBlastocyst embryosCellsDifferent subsetsVast majorityCell descendantsPrevious studiesCortexMice
1973
Organization of cerebellar cortex secondary to deficit of granule cells in weaver mutant mice
Rakic P, Sidman R. Organization of cerebellar cortex secondary to deficit of granule cells in weaver mutant mice. The Journal Of Comparative Neurology 1973, 152: 133-161. PMID: 4761656, DOI: 10.1002/cne.901520203.Peer-Reviewed Original ResearchConceptsGranule cellsExternal granular layerGolgi type II neuronsPurkinje cellsHeterozygous weaver miceType II neuronsMossy fiber terminalsWeaver mutant micePurkinje cell dendritesGranular layerExternal granule cellsIntrinsic axonsLocal cellular milieuSynaptic contactsForm synapsesEarly recognitionAxonal contactCell dendritesPostsynaptic elementsBergmann glial fibersMembrane thickeningMossy fibersDendritic spinesFiber terminalsMolecular layerSequence of developmental abnormalities leading to granule cell deficit in cerebellar cortex of weaver mutant mice
Rakic P, Sidman R. Sequence of developmental abnormalities leading to granule cell deficit in cerebellar cortex of weaver mutant mice. The Journal Of Comparative Neurology 1973, 152: 103-132. PMID: 4128371, DOI: 10.1002/cne.901520202.Peer-Reviewed Original ResearchWeaver Mutant Mouse Cerebellum: Defective Neuronal Migration Secondary to Abnormality of Bergmann Glia
Rakic P, Sidman R. Weaver Mutant Mouse Cerebellum: Defective Neuronal Migration Secondary to Abnormality of Bergmann Glia. Proceedings Of The National Academy Of Sciences Of The United States Of America 1973, 70: 240-244. PMID: 4509657, PMCID: PMC433223, DOI: 10.1073/pnas.70.1.240.Peer-Reviewed Original ResearchConceptsDefective neuronal migrationGene dosage effectPrimary cellular targetSite of genesisGenetic lociCellular targetsPrimary genetic abnormalityCell deathBergmann glial cellsDosage effectCellular levelGranule cell deathNeuronal migrationCell processesCell genesisNeurological mutantPhenotypic expressionBergmann glial processesGlial cellsCell neuronsGenetic abnormalitiesYoung neuronsWv/wvCerebellum of miceGlial abnormalities