2010
Gap Junctions/Hemichannels Modulate Interkinetic Nuclear Migration in the Forebrain Precursors
Liu X, Hashimoto-Torii K, Torii M, Ding C, Rakic P. Gap Junctions/Hemichannels Modulate Interkinetic Nuclear Migration in the Forebrain Precursors. Journal Of Neuroscience 2010, 30: 4197-4209. PMID: 20335455, PMCID: PMC2861434, DOI: 10.1523/jneurosci.4187-09.2010.Peer-Reviewed Original Research4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAdenosine TriphosphateAnimalsBoron CompoundsBromodeoxyuridineCalciumCalcium SignalingCarbenoxoloneCell Line, TumorCell MovementCell NucleusCerebral VentriclesChelating AgentsConnexin 43Cyclooxygenase InhibitorsEgtazic AcidEmbryo, MammalianFemaleGap JunctionsGreen Fluorescent ProteinsKi-67 AntigenMeclofenamic AcidMiceNeuroblastomaNeuronsOrgan Culture TechniquesPatch-Clamp TechniquesPlatelet Aggregation InhibitorsPregnancyProsencephalonPyridoxal PhosphateStem Cells
2001
Cell Proliferation Without Neurogenesis in Adult Primate Neocortex
Kornack D, Rakic P. Cell Proliferation Without Neurogenesis in Adult Primate Neocortex. Science 2001, 294: 2127-2130. PMID: 11739948, DOI: 10.1126/science.1065467.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesBrainBromodeoxyuridineCell DeathCell DivisionCell MovementEndothelium, VascularFemaleFluorescent Antibody TechniqueGlial Fibrillary Acidic ProteinImmunoenzyme TechniquesMacaca fascicularisMacaca mulattaMaleMicroscopy, ConfocalMicroscopy, FluorescenceNeocortexNeuronsNuclear ProteinsTubulinConceptsPrimate neocortexGlial cell markersAdult macaque monkeysNew neuronsNumerous BrdUOlfactory bulbCerebral wallAdult macaquesMacaque monkeysNonneuronal cellsHigher cognitive functionsCell markersCognitive functionNeocortexNeurogenesisTriple labelingCellular mechanismsCell proliferationNeuronsCellsHippocampusMode and Tempo of Tangential Cell Migration in the Cerebellar External Granular Layer
Komuro H, Yacubova E, Yacubova E, Rakic P. Mode and Tempo of Tangential Cell Migration in the Cerebellar External Granular Layer. Journal Of Neuroscience 2001, 21: 527-540. PMID: 11160432, PMCID: PMC6763794, DOI: 10.1523/jneurosci.21-02-00527.2001.Peer-Reviewed Original Research
2000
Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones
Haydar T, Wang F, Schwartz M, Rakic P. Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones. Journal Of Neuroscience 2000, 20: 5764-5774. PMID: 10908617, PMCID: PMC3823557, DOI: 10.1523/jneurosci.20-15-05764.2000.Peer-Reviewed Original ResearchMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAnimalsAntimetabolitesBromodeoxyuridineCell DifferentiationCell DivisionCell MovementCerebral VentriclesClone CellsExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsFetusGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGlutamic AcidKainic AcidMiceMice, Inbred ICRMuscimolNeocortexNeuronsOrgan Culture TechniquesStem CellsConceptsVentricular zoneNeural progenitor populationsNeural progenitor proliferationSubventricular zoneProgenitor populationsCell cycleProgenitor cloneProgenitor proliferationEmbryonic cerebrumNeocortical growthProliferationDifferential responsivenessRecent studiesBromodeoxyuridine uptakeDifferential modulationOrganotypic slice culturesClassical neurotransmitters GABAOpposite effectNeurotransmitter GABARelative contributionClonesDisparate effectsRegulationSlice culturesSpecific GABA
1999
Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex1Published on the World Wide Web on 8 July 1999.1
Haydar T, Bambrick L, Krueger B, Rakic P. Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex1Published on the World Wide Web on 8 July 1999.1. Brain Research 1999, 4: 425-437. PMID: 10592354, DOI: 10.1016/s1385-299x(99)00033-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBromodeoxyuridineCell DivisionCell MovementCell SurvivalFemaleFetusFluorescent Antibody TechniqueGlial Fibrillary Acidic ProteinIn Situ Nick-End LabelingMiceMice, Inbred ICRMicroscopy, ConfocalMicrotubule-Associated ProteinsNeocortexNeurogliaNeuronsOrgan Culture TechniquesPregnancyConceptsCell deathProper cortical developmentCell-cell interactionsDynamic cellular interactionsQuantitative confocal microscopyDiffusible regulatorsPrimary cell culturesAnalysis of proliferationCellular interactionsCellular mechanismsCortical neurogenesisNeuronal migrationConfocal microscopyCell proliferationNeocortical neurogenesisExperimental manipulationThree-dimensional environmentVivo processesCell culturesNeurogenesisPhysiological methodsTropic supportOrganotypic slice culturesProliferationCortical developmentContinuation of neurogenesis in the hippocampus of the adult macaque monkey
Kornack D, Rakic P. Continuation of neurogenesis in the hippocampus of the adult macaque monkey. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 5768-5773. PMID: 10318959, PMCID: PMC21935, DOI: 10.1073/pnas.96.10.5768.Peer-Reviewed Original ResearchConceptsAdult macaque monkeysDentate gyrusMacaque monkeysAdult primate hippocampusAdult rodent dentate gyrusImmunohistochemical double labelingHippocampal dentate gyrusRodent dentate gyrusDiscreet brain regionsMultipotent neural stem cellsNeural stem cellsAdult neurogenesisAdult brainPrimate hippocampusAnimal modelsBrain regionsDouble labelingNeurogenesisSpecific markersHippocampusGyrusStem cellsCell typesMonkeysHumans
1998
Changes in cell-cycle kinetics during the development and evolution of primate neocortex
Kornack D, Rakic P. Changes in cell-cycle kinetics during the development and evolution of primate neocortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 1242-1246. PMID: 9448316, PMCID: PMC18732, DOI: 10.1073/pnas.95.3.1242.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBromodeoxyuridineCell CycleCell DivisionDNA ReplicationFemaleMacaca mulattaMaleMiceNeocortexPregnancyS PhaseConceptsCell divisionCell division cycleCell cycle kineticsProgenitor cell divisionCell cycle lengthCell cycle durationEvolutionary modificationsEvolutionary expansionCerebral ventricular zoneDevelopmental basisCell productionPrimate neocortexS-phase labelingAnthropoid primatesProgenitor cellsFetal rhesus monkeysNeurogenetic periodVentricular zoneNeocortical sizeCortical cellsNeurogenesisCortical developmentMonkey cortexTotal roundsCortical layers