2023
Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon
Micali N, Ma S, Li M, Kim S, Mato-Blanco X, Sindhu S, Arellano J, Gao T, Shibata M, Gobeske K, Duque A, Santpere G, Sestan N, Rakic P. Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon. Science 2023, 382: eadf3786. PMID: 37824652, PMCID: PMC10705812, DOI: 10.1126/science.adf3786.Peer-Reviewed Original Research
2001
Neurocreationism--Making New Cortical Maps
Rakic P. Neurocreationism--Making New Cortical Maps. Science 2001, 294: 1011-1012. PMID: 11691974, DOI: 10.1126/science.294.5544.1011.Peer-Reviewed Original ResearchTelencephalic origin of human thalamic GABAergic neurons
Letinic K, Rakic P. Telencephalic origin of human thalamic GABAergic neurons. Nature Neuroscience 2001, 4: 931-936. PMID: 11528425, DOI: 10.1038/nn0901-931.Peer-Reviewed Original ResearchConceptsNon-primate mammalian speciesHomeodomain-containing proteinMigratory pathwaysThalamic association nucleiVital dye labelingEvolutionary expansionMammalian speciesAssociation nucleiTelencephalic cellsRodent embryosGuidance cuesChemorepulsive cuesMigration assaysOrganotypic slice culturesDye labelingProliferative zoneNon-human primatesGABAergic neuronsDiencephalic neuronsPathwayDorsal thalamusTelencephalic originGanglionic eminenceSlice culturesNeuronsBcl-XL–Caspase-9 Interactions in the Developing Nervous System: Evidence for Multiple Death Pathways
Zaidi A, D'Sa-Eipper C, Brenner J, Kuida K, Zheng T, Flavell R, Rakic P, Roth K. Bcl-XL–Caspase-9 Interactions in the Developing Nervous System: Evidence for Multiple Death Pathways. Journal Of Neuroscience 2001, 21: 169-175. PMID: 11150333, PMCID: PMC6762421, DOI: 10.1523/jneurosci.21-01-00169.2001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBcl-2-Associated X ProteinBcl-X ProteinCaspase 3Caspase 9CaspasesCells, CulturedCytarabineGanglia, SpinalGenes, LethalHeterozygoteHomozygoteImmunohistochemistryIn Situ Nick-End LabelingLiverMiceMice, KnockoutNervous SystemNeuronsProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2TelencephalonTumor Suppressor Protein p53ConceptsGene family membersCaspase-9 deficiencyCaspase-9Telencephalic neural precursor cellsCell deathDouble homozygous mutantsCaspase family membersMultiple death pathwaysNormal nervous system developmentBcl-2Nervous system developmentBax-deficient neuronsNeuronal apoptosisTelencephalic neuronsDeficient embryosNeural precursor cellsDeath pathwaysFamily membersHomozygous mutantsApoptotic pathwayObligate pathwayBcl-xLApoptosis inducersDeficient neuronsTargeted disruption
2000
Amyloid Beta-Induced Neuronal Death is Bax-Dependent but Caspase-Independent
Selznick L, Zheng T, Flavell R, Rakic P, Roth K. Amyloid Beta-Induced Neuronal Death is Bax-Dependent but Caspase-Independent. Journal Of Neuropathology & Experimental Neurology 2000, 59: 271-279. PMID: 10759182, DOI: 10.1093/jnen/59.4.271.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid Chloromethyl KetonesAmyloid beta-PeptidesAnimalsApoptosisBcl-2-Associated X ProteinCaspase 3Caspase InhibitorsCaspasesCell DeathCells, CulturedCysteine Proteinase InhibitorsDose-Response Relationship, DrugFemaleGlycoproteinsIn Situ Nick-End LabelingMaleMiceMice, KnockoutMicrotubule-Associated ProteinsMicrotubulesNeuronsPaclitaxelProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2TelencephalonConceptsNeuronal deathNeuronal apoptosisCaspase-3 activationTelencephalic neuronsFibrillar amyloid-beta (Abeta) peptidesAbeta-induced neuronal apoptosisAD treatment strategiesAbeta-induced neuronal deathPathogenesis of ADAlzheimer's disease brainEffects of AbetaAmyloid-beta peptideApoptotic nuclear featuresUnderlying pathophysiologyTreatment strategiesDisease brainSenile plaquesNeurotoxic effectsAmyloid betaCalpain inhibitionPharmacological inhibitionBeta peptideNuclear featuresAbetaCaspase-3
1993
Low-affinity p75 nerve growth factor receptor expression in the embryonic monkey telencephalon: Timing and localization in diverse cellular elements
Meinecke D, Rakic P. Low-affinity p75 nerve growth factor receptor expression in the embryonic monkey telencephalon: Timing and localization in diverse cellular elements. Neuroscience 1993, 54: 105-116. PMID: 8515837, DOI: 10.1016/0306-4522(93)90386-t.Peer-Reviewed Original ResearchConceptsDiverse cellular elementsNerve growth factor receptorGrowth factor receptorCerebral cortexCellular elementsFactor receptorAxonal processesNerve growth factor receptor expressionLow-affinity nerve growth factor receptorGrowth factorEmbryonic day 45Transient subplate neuronsGrowth factor receptor expressionFactor receptor expressionOnset of neurogenesisNerve growth factorHuman nerve growth factor receptorGrowth factor familyMonkey telencephalonSubplate neuronsSubplate zoneReceptor expressionFetal brainActive neurogenesisNeuronal proliferation
1992
Dividing Up the Neocortex
Rakic P. Dividing Up the Neocortex. Science 1992, 258: 1421-1422. PMID: 1439833, DOI: 10.1126/science.258.5087.1421-b.Peer-Reviewed Original Research
1980
Immunoperoxidase localization of glial fibrillary acidic protein in radial glial cells and astrocytes of the developing rhesus monkey brain
Levitt P, Rakic P. Immunoperoxidase localization of glial fibrillary acidic protein in radial glial cells and astrocytes of the developing rhesus monkey brain. The Journal Of Comparative Neurology 1980, 193: 815-840. PMID: 7002963, DOI: 10.1002/cne.901930316.Peer-Reviewed Original ResearchConceptsGlial fibrillary acidic proteinRadial glial cellsGlial cellsFibrillary acidic proteinBergmann glial cellsGlial fibersNeuronal elementsPial surfacePeroxidase-antiperoxidase immunohistochemical stainingAcidic proteinNeuronal migrationEmbryonic day 38Rhesus monkey brainSecond postnatal monthCentral nervous systemHorseradish peroxidase reaction productRadial fibersSpinal cordPostnatal monthBergmann glial fibersSubventricular zoneImmunohistochemical stainingAstroglial cellsCerebellar cortexImmunohistochemical localizationCytology and time of origin of interstitial neurons in the white matter in infant and adult human and monkey telencephalon
Kostovic I, Rakic P. Cytology and time of origin of interstitial neurons in the white matter in infant and adult human and monkey telencephalon. Brain Cell Biology 1980, 9: 219-242. PMID: 7441294, DOI: 10.1007/bf01205159.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholinesteraseAdultAnimalsGestational AgeHumansInfantMacaca mulattaNeuronsOrganoidsSynapsesTelencephalonConceptsInterstitial neuronsMonkey telencephalonWhite matterInterstitial cellsSomatosensory motor cortexDeep neocortical layersEarly postnatal daysRapid Golgi impregnationsCentral nervous systemSpecific AChE activityGeneration of neuronsAxodendritic synapsesNeonatal periodMotor cortexSubplate layerSynaptic relationshipsNeurons decreasesPostnatal dayAcetylcholinesterase histochemistryGolgi impregnationNervous systemNeocortical layersRhesus monkeysFusiform cellsPolymorphic cells
1979
Arrested proliferation of radial glial cells during midgestation in rhesus monkey
SCHMECHEL D, RAKIC P. Arrested proliferation of radial glial cells during midgestation in rhesus monkey. Nature 1979, 277: 303-305. PMID: 105294, DOI: 10.1038/277303a0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCell DivisionCerebral CortexGestational AgeHaplorhiniNeurogliaOccipital LobeTelencephalonConceptsRadial glial cellsGlial cellsPial surfaceCerebral cortexGlial natureOccipital lobeTelencephalic wallEpendymal cellsGlial fibersRhesus monkeysNeuronal migrationCell classesAutoradiographic analysisVentricular surfaceAstrocytesTwo-thirdsMidgestationPresent studyCellsProliferationGestationPostnatalCerebrumCortexMonthsA golgi study of radial glial cells in developing monkey telencephalon: Morphogenesis and transformation into astrocytes
Schmechel D, Rakic P. A golgi study of radial glial cells in developing monkey telencephalon: Morphogenesis and transformation into astrocytes. Brain Structure And Function 1979, 156: 115-152. PMID: 111580, DOI: 10.1007/bf00300010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesCell NucleusHaplorhiniMacacaMacaca mulattaNeurogliaTelencephalonTime FactorsConceptsRadial glial cellsGlial cellsCerebral wallSubventricular zoneOccipital lobeRadial fibersPial surfaceRadial glial fibersRapid Golgi methodMedial cerebral wallMonkey telencephalonCalcarine fissureCortical plateGolgi studyLateral ventricleProtoplasmic astrocytesLarge oval nucleiDay 365Ependymal cellsGlial fibersAstrocytesRhesus monkeysOlder ageDay 48Oval nuclei
1972
Mode of cell migration to the superficial layers of fetal monkey neocortex
Rakic P. Mode of cell migration to the superficial layers of fetal monkey neocortex. The Journal Of Comparative Neurology 1972, 145: 61-83. PMID: 4624784, DOI: 10.1002/cne.901450105.Peer-Reviewed Original Research
1969
Telencephalic origin of pulvinar neurons in the fetal human brain
Rakić P, Sidman R. Telencephalic origin of pulvinar neurons in the fetal human brain. Brain Structure And Function 1969, 129: 53-82. PMID: 4186810, DOI: 10.1007/bf00521955.Peer-Reviewed Original ResearchConceptsPulvinar neuronsWeeks of gestationPrevious autoradiographic studiesEnd of gestationRapid Golgi methodFetal human brainSerial horizontal sectionsNumerous proliferating cellsCorpus striatumYoung neuronsLateral ventricleHuman thalamusTelencephalic originThird ventricleNeuron productionSulcus terminalisBipolar cellsGanglionic eminenceAutoradiographic studyPulvinarImmature cellsGolgi methodGestationBrain fragmentsNeurons