2024
Safety and Efficacy of a Composite Lipid Emulsion with Fish Oil in Hospitalized Neonates and Infants Requiring Prolonged Parenteral Nutrition - A Randomized, Double-Blind, Multicenter, Controlled Trial
Abrams S, Ernst K, Weitkamp J, Mascarenhas M, Anderson-Berry A, Rudolph J, Ling C, Robinson D, Shores D, Hair A, Lai J, Lane B, McCallie K, Levit O, Kim J. Safety and Efficacy of a Composite Lipid Emulsion with Fish Oil in Hospitalized Neonates and Infants Requiring Prolonged Parenteral Nutrition - A Randomized, Double-Blind, Multicenter, Controlled Trial. Journal Of Nutrition 2024 PMID: 39374788, DOI: 10.1016/j.tjnut.2024.10.005.Peer-Reviewed Original ResearchSoybean oil lipid emulsionsInitial treatment phaseHigh-risk neonatesParenteral nutritionTreatment phaseLipid emulsionDouble-blindEfficacy of parenteral nutritionEvidence of essential fatty acid deficiencyComposite lipid emulsionProlonged parenteral nutritionRisk of cholestasisEssential fatty acid deficiencyHigh-risk infantsIntravenous lipid emulsionFatty acid deficiencyExtended treatment phaseIntravenous lipidsHospitalized neonatesConjugated bilirubin concentrationsMedian timeGastrointestinal malformationsMulticenter studyLaboratory evidencePrimary outcome
2014
Low‐Dose Intravenous Soybean Oil Emulsion for Prevention of Cholestasis in Preterm Neonates
Levit OL, Calkins KL, Gibson LC, Kelley‐Quon L, Robinson DT, Elashoff DA, Grogan TR, Li N, Bizzarro MJ, Ehrenkranz RA. Low‐Dose Intravenous Soybean Oil Emulsion for Prevention of Cholestasis in Preterm Neonates. Journal Of Parenteral And Enteral Nutrition 2014, 40: 374-382. PMID: 24963025, PMCID: PMC4537394, DOI: 10.1177/0148607114540005.Peer-Reviewed Original ResearchConceptsDays of lifeIntravenous fat emulsionPreterm neonatesPrimary outcomeGestational ageControl groupControl doseFat emulsionDays of PNFull enteral feedsPrevention of cholestasisMajor neonatal morbidityHours of lifeEffective preventive strategiesLow groupHospital stayNeonatal morbidityBaseline characteristicsParenteral nutritionSecondary outcomesEnteral feedsEssential fatty acidsPremature infantsLiver diseaseTotal bilirubin