Safety and Efficacy of a Composite Lipid Emulsion with Fish Oil in Hospitalized Neonates and Infants Requiring Prolonged Parenteral Nutrition - A Randomized, Double-Blind, Multicenter, Controlled Trial
Abrams S, Ernst K, Weitkamp J, Mascarenhas M, Anderson-Berry A, Rudolph J, Ling C, Robinson D, Shores D, Hair A, Lai J, Lane B, McCallie K, Levit O, Kim J. Safety and Efficacy of a Composite Lipid Emulsion with Fish Oil in Hospitalized Neonates and Infants Requiring Prolonged Parenteral Nutrition - A Randomized, Double-Blind, Multicenter, Controlled Trial. Journal Of Nutrition 2024 PMID: 39374788, DOI: 10.1016/j.tjnut.2024.10.005.Peer-Reviewed Original ResearchSoybean oil lipid emulsionsInitial treatment phaseHigh-risk neonatesParenteral nutritionTreatment phaseLipid emulsionDouble-blindEfficacy of parenteral nutritionEvidence of essential fatty acid deficiencyComposite lipid emulsionProlonged parenteral nutritionRisk of cholestasisEssential fatty acid deficiencyHigh-risk infantsIntravenous lipid emulsionFatty acid deficiencyExtended treatment phaseIntravenous lipidsHospitalized neonatesConjugated bilirubin concentrationsMedian timeGastrointestinal malformationsMulticenter studyLaboratory evidencePrimary outcome