Surrogate endpoints: a key concept in clinical epidemiology
Christensen R, Ciani O, Manyara A, Taylor R. Surrogate endpoints: a key concept in clinical epidemiology. Journal Of Clinical Epidemiology 2023, 167: 111242. PMID: 38142762, DOI: 10.1016/j.jclinepi.2023.111242.Peer-Reviewed Original ResearchPatient-important outcomesSurrogate endpointsClinical outcomesTrue clinical outcomeClinical trialsClinical epidemiologyRobust scientific evidenceHealth outcomesIntermediate outcomesEndpointMeaningful cutoffsScientific evidenceOutcomesTreatment effectsPatientsInterventionSpecific changesRigorous evaluationEpidemiologyTrialsBiomarkers