2022
De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report
Gandhi S, Klein J, Robertson AJ, Peña-Hernández MA, Lin MJ, Roychoudhury P, Lu P, Fournier J, Ferguson D, Mohamed Bakhash SAK, Catherine Muenker M, Srivathsan A, Wunder EA, Kerantzas N, Wang W, Lindenbach B, Pyle A, Wilen CB, Ogbuagu O, Greninger AL, Iwasaki A, Schulz WL, Ko AI. De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report. Nature Communications 2022, 13: 1547. PMID: 35301314, PMCID: PMC8930970, DOI: 10.1038/s41467-022-29104-y.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionVirologic responsePersistent SARS-CoV-2 infectionResistance mutationsPre-treatment specimensB-cell deficiencyRemdesivir resistanceRemdesivir therapyViral sheddingCase reportAntiviral agentsPatientsCombinatorial therapyInfectionTherapyWhole-genome sequencingTreatmentImportance of monitoringDe novo emergenceFold increaseRNA-dependent RNA polymeraseNovo emergencePotential benefitsMutationsIndolent
2021
A new positive SARS-CoV-2 test months after severe COVID-19 illness: reinfection or intermittent viral shedding?
Tuan J, Spichler-Moffarah A, Ogbuagu O. A new positive SARS-CoV-2 test months after severe COVID-19 illness: reinfection or intermittent viral shedding? BMJ Case Reports 2021, 14: e240531. PMID: 33542020, PMCID: PMC8098910, DOI: 10.1136/bcr-2020-240531.Peer-Reviewed Case Reports and Technical NotesConceptsSARS-CoV-2 RNA testSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2SARS-CoV-2 reinfectionSevere COVID-19 illnessRespiratory syndrome coronavirus 2COVID-19 reinfectionLong asymptomatic periodCOVID-19 illnessSyndrome coronavirus 2Intermittent viral sheddingAsymptomatic periodViral sheddingRNA testCoronavirus 2Clinical managementPersistent infectionDisease 4Molecular testingReinfectionRNA PCRCurrent presentationPotential casesMonthsPatients
2018
The Changing Face of HIV Care
Barakat LA, Dunne DW, Tetrault JM, Soares S, Chia D, Ogbuagu OE, Moriarty JP, Huot SJ, Green ML. The Changing Face of HIV Care. Academic Medicine 2018, 93: 1673-1678. PMID: 29901657, DOI: 10.1097/acm.0000000000002317.Peer-Reviewed Original ResearchConceptsHIV carePrimary careRisk of comorbiditiesPrimary care residency programsEntrustable professional activitiesHigh-quality HIVHIV/AIDSResidency programsInternal medicine residency programsMedicine residency programsHIV trainingShortage of physiciansHIVClinical training opportunitiesResident schedulesCarePatientsNeeds assessmentSingle settingPhysician workforceWeb-based curriculumProgram evaluationTraining trackComorbiditiesTraining opportunitiesInfections in HIV-Infected Patients
Ogbuagu O, Bruce R. Infections in HIV-Infected Patients. 2018, 243-281. DOI: 10.1007/978-3-319-77674-3_13.ChaptersHuman immunodeficiency virusCombination antiretroviral therapyCD4 countCertain infectionsLife-threatening infectious complicationsHigher CD4 countsAntiretroviral therapyImmune reconstitutionInfectious complicationsUntreated patientsImmune defectsClinical presentationImmunodeficiency syndromeCommon infectionsImmunodeficiency virusPatientsNatural historyInfectionChief causeCountCD4ComplicationsSequelaePrognosisPathogenesis
2015
CD8 T-Cell Lymphocytosis and Associated Clinical Syndromes in HIV-Infected Patients.
Tiberio PJ, Ogbuagu OE. CD8 T-Cell Lymphocytosis and Associated Clinical Syndromes in HIV-Infected Patients. Aids Reviews 2015, 17: 202-11. PMID: 26679852.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements