2023
Anticoagulation and hemostasis on extracorporeal membrane oxygenation
Carmona C, Nellis M, Karam O. Anticoagulation and hemostasis on extracorporeal membrane oxygenation. Current Opinion In Pediatrics 2023, 35: 297-302. PMID: 36974451, DOI: 10.1097/mop.0000000000001247.Peer-Reviewed Original ResearchConceptsHemostatic transfusionsMembrane oxygenationPlatelet transfusionsProspective randomized trialsOptimal anticoagulation strategyExtracorporeal membrane oxygenationPlatelet transfusion strategyRecent systematic reviewHemostatic changesAnticoagulation strategiesFrequent complicationMost patientsThrombotic complicationsTransfusion strategyRandomized trialsCareful titrationObservational studyTransfusionSystematic reviewAnticoagulationECMOComplicationsBleedingTwo-fold decreaseRisk
2022
Anticoagulation strategies and recurrence of venous thromboembolic events in patients with sickle cell disease: a systematic review and meta-analysis
El-Amin N, Iness A, Cyrus JW, Sisler I, Karam O. Anticoagulation strategies and recurrence of venous thromboembolic events in patients with sickle cell disease: a systematic review and meta-analysis. Annals Of Hematology 2022, 101: 1931-1940. PMID: 35895101, DOI: 10.1007/s00277-022-04901-z.Peer-Reviewed Original ResearchConceptsVenous thromboembolic eventsSickle cell diseaseCell diseaseThromboembolic eventsPulmonary embolismSystematic reviewDevelopment of bleedingOverall bleeding rateVenous thrombotic eventsRisk of mortalityProgression of thrombusAnticoagulant classDifferent anticoagulationAnticoagulation strategiesOverall recurrenceOverall mortalityThrombotic eventsAdverse outcomesPatient populationBleeding rateObservational studyOutcome measuresAppropriate managementPatientsRecurrence
2021
Accuracy of Bioimpedance Modalities for Fluid Assessment in Hemodialysis Patients: A Randomized Observational Study
John J, Division of Pediatric Nephrology C, Gipson G, King C, Bunchman T, Karam O, Division of Nephrology V, Division of Pediatric Critical Care Medicine C. Accuracy of Bioimpedance Modalities for Fluid Assessment in Hemodialysis Patients: A Randomized Observational Study. Nephrology - Open Journal 2021, 6: 1-7. DOI: 10.17140/npoj-6-124.Peer-Reviewed Original ResearchEnd-stage renal disease patientsRenal disease patientsTotal body water volumeDisease patientsObservational studyFluid volumeBody weightMethods Prospective observational studyBody water volumeProspective observational studyTertiary care centerAdult patientsFluid overloadHemodialysis patientsIll patientsBland-Altman analysisCare centerFluid assessmentResults TwentyPatientsBioimpedance analysisStudy assessmentBioimpedance spectroscopyDialysisBioimpedancePain Assessment and Management in Pediatric Intensive Care Units Around the World, an International, Multicenter Study
Grunauer M, Mikesell C, Bustamante G, Cobo G, Sánchez S, Román A, Icaza-Freire A, Gavilanes A, Wang N, Group T, González J, López-Herce J, Rossetti E, Fabrizio C, Karam O, Saint-Faust M, Biban P, Carlassara S, von Dessauer B, Ordenes N, Urízar F, A A, Canarie M, Miller K, Irazuzta J, Chiriboga N, Tawfik D, Sourkes B, Wang N, Vongsachang H, Tucker E, Shilkofski N, Wang 王, Wenchao R, Yuxia Z, See L, Priscilla, Tekin R, Aktar F, Düzkaya D, Dursun O, Ongun E, Yilmaz R, Yildizdas D, Tekgüç H, Sazonov V, Tsoy T, Sazonov V, Saparov A, Sazonov V, Kalmbakh E, Grunauer M, Eguiguren L, Claudette K, Tovilla Y, Gómez S, Torres S, Cobarrubias P, Dmytriiev D, Martínez A, Guzaman G, Sanabria R, Krupanandan R, Ramachandran B, Choraria N, Patel J, Pooni P, Gill K, Appiah J, Anokye K, Heye T, Argaw R, Demtse A, Admasu I. Pain Assessment and Management in Pediatric Intensive Care Units Around the World, an International, Multicenter Study. Frontiers In Pediatrics 2021, 9: 746489. PMID: 34778135, PMCID: PMC8581242, DOI: 10.3389/fped.2021.746489.Peer-Reviewed Original ResearchPediatric intensive care unitIntensive care unitCare unitPain assessmentMulticenter cross-sectional observational studyCross-sectional observational studyPain management expertsPain management scoresPalliative care recommendationsManagement of painIncome countriesPain reliefMulticenter studyCare recommendationsObservational studyHigh-income countriesPainRoutine assessmentMedical doctorsAdequate assessmentManagement scoresAssessmentLack of resourcesRural areasSignificant trendPerformance of Platelet Mass Index as a Marker of Severity for Sepsis and Septic Shock in Children
Chegondi M, Vijayakumar N, Billa R, Badheka A, Karam O. Performance of Platelet Mass Index as a Marker of Severity for Sepsis and Septic Shock in Children. Journal Of Pediatric Intensive Care 2021, 12: 228-234. PMID: 37565022, PMCID: PMC10411082, DOI: 10.1055/s-0041-1731434.Peer-Reviewed Original ResearchPlatelet mass indexPediatric intensive care unitSeptic shockPICU admissionMass indexPrognostic indicatorFl/Day 1Marker of severityRetrospective observational studyIntensive care unitCare unitPediatric sepsisObservational studyClinical valueDay 3SepsisCharacteristic curveFurther studiesAdmissionPMI valuesChildrenAUCSpecificityNonsurvivorsEpidemiology of the Use of Hemostatic Agents in Children Supported by Extracorporeal Membrane Oxygenation: A Pediatric Health Information System Database Study
Nellis ME, Vasovic LV, Goel R, Karam O. Epidemiology of the Use of Hemostatic Agents in Children Supported by Extracorporeal Membrane Oxygenation: A Pediatric Health Information System Database Study. Frontiers In Pediatrics 2021, 9: 673613. PMID: 34041211, PMCID: PMC8141845, DOI: 10.3389/fped.2021.673613.Peer-Reviewed Original ResearchHemostatic blood productsECMO daysPercent of childrenBlood productsMembrane oxygenationPediatric Health Information System Database StudyPediatric Health Information System databaseHealth Information System databaseUse of TXAHospital mortality rateRetrospective observational studyU.S. children's hospitalsExtracorporeal membrane oxygenationMedian ageChildren's HospitalMedian lengthHemostatic measuresInformation System databaseObservational studyECMODatabase studyHigh riskMortality rateHemostatic agentsFactor VIIa
2020
Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis
Willems A, Roeleveld PP, Labarinas S, Cyrus JW, Muszynski JA, Nellis ME, Karam O. Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis. Perfusion 2020, 36: 501-512. PMID: 32862767, PMCID: PMC8216320, DOI: 10.1177/0267659120952982.Peer-Reviewed Original ResearchConceptsAnticoagulation strategiesMortality rateThrombotic eventsObservational studySystematic reviewProportion of bleedingType of ECMOExtracorporeal membrane oxygenationMultiple electronic databasesLower mortality rateMembrane oxygenationPatientsElectronic databasesECMOThrombosisSignificant differencesXaBleedingReviewMortalityStudyPreoperative erythropoietin within a patient blood management program decreases both blood transfusion and postoperative anemia: a prospective observational study
Biboulet P, Motais C, Pencole M, Karam O, Dangelser G, Smilevitch P, Maissiat G, Capdevila X, Bringuier S. Preoperative erythropoietin within a patient blood management program decreases both blood transfusion and postoperative anemia: a prospective observational study. Transfusion 2020, 60: 1732-1740. PMID: 32681743, DOI: 10.1111/trf.15900.Peer-Reviewed Original ResearchConceptsPatient blood management programBlood management programBlood transfusionPostoperative anemiaPreoperative erythropoietinObservational studyElective primary hipProspective observational studyMajor thromboembolicPreoperative hemoglobinCardiovascular eventsPreoperative treatmentTransfusion rateHospital dischargePostoperative infusionPostoperative periodIntraoperative administrationMajor complicationsTranexamic acidPrimary hipKnee arthroplastySingle hospitalTransfusionPatientsSpecific efficacyPediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines.
Nellis ME, Saini A, Spinella PC, Davis PJ, Steiner ME, Tucci M, Cushing M, Demaret P, Stanworth SJ, Leteurtre S, Karam O. Pediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines. Pediatric Critical Care Medicine 2020, 21: 267-275. PMID: 31644453, PMCID: PMC7060816, DOI: 10.1097/pcc.0000000000002160.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood TransfusionChildChild, PreschoolExtracorporeal Membrane OxygenationFemaleHemorrhageHumansInfantInfant, NewbornIntensive Care Units, PediatricInternational Normalized RatioMalePlasmaPlatelet CountPlatelet TransfusionPractice Guidelines as TopicProspective StudiesSurveys and QuestionnairesConceptsExtracorporeal membrane oxygenationMembrane oxygenationPlatelet transfusionsTotal platelet countPlasma transfusionPlatelet countSubgroup analysisInstitutional protocolMedian increaseInternational point prevalence studyPediatric extracorporeal membrane oxygenationTotal median doseInternational normalized ratioML/Point prevalence studyPlatelet count valuesScreening weekMedian doseMild coagulopathyNormalized ratioInterventional studyLocal guidelinesObservational studyMedian reductionTransfusion
2019
International Study of the Epidemiology of Platelet Transfusions in Critically Ill Children With an Underlying Oncologic Diagnosis.
Nellis ME, Goel R, Karam O, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC. International Study of the Epidemiology of Platelet Transfusions in Critically Ill Children With an Underlying Oncologic Diagnosis. Pediatric Critical Care Medicine 2019, 20: e342-e351. PMID: 31107379, DOI: 10.1097/pcc.0000000000001987.Peer-Reviewed Original ResearchConceptsPlatelet transfusionsOncologic diagnosisIll childrenCurrent recommendationsHematopoietic stem cell transplantationCritically Ill ChildrenExtracorporeal life supportStem cell transplantationTotal platelet countMechanical ventilationPlatelet countAppropriate indicationsCell transplantationPediatric intensivistsSubgroup analysisObservational studyPlatelet functionTransfusionParent studyTherapeutic transfusionTotal plateletsLife supportDiagnosisVulnerable populationsSignificant differences
2018
International, multicentre, observational study of fluid bolus therapy in neonates
Keir AK, Karam O, Hodyl N, Stark MJ, Liley HG, Shah PS, Stanworth SJ, Group O. International, multicentre, observational study of fluid bolus therapy in neonates. Journal Of Paediatrics And Child Health 2018, 55: 632-639. PMID: 30328174, DOI: 10.1111/jpc.14260.Peer-Reviewed Original ResearchConceptsFluid bolus therapyBolus therapyNeonatal unitHaemodynamic compromiseObservational studyFluid bolus administrationMulticentre observational studyRisk-benefit profilePooled prevalence rateWide international variationDays of ageClinical improvementFrequent indicationAppropriate indicationsFluid bolusMetabolic acidosisPoor perfusionPatient daysBolus administrationPrevalence ratesStudy daysNeonatesStudy periodTherapyRelevant studiesEffects of plasma transfusions on antithrombin levels after paediatric liver transplantation
Arni D, Wildhaber BE, McLin V, Rimensberger PC, Ansari M, Fontana P, Karam O. Effects of plasma transfusions on antithrombin levels after paediatric liver transplantation. Vox Sanguinis 2018, 113: 569-576. PMID: 29761839, DOI: 10.1111/vox.12664.Peer-Reviewed Original ResearchLiver transplantationPediatric liver transplantationPlasma transfusionAT levelsProspective single-center observational studySingle-center observational studyPediatric LT patientsPro-thrombotic profileProphylactic plasma transfusionLife-threatening complicationsPediatric LT recipientsOptimal anticoagulation strategyPro-coagulant factorsNon-inferiority hypothesisLT patientsAnticoagulation strategiesLT recipientsAntithrombin levelsThrombotic complicationsMedian agePatient weightObservational studyRoutine managementTransfusionBlood samples
2017
Outcomes Related to the Use of Frozen Plasma or Pooled Solvent/Detergent-Treated Plasma in Critically Ill Children*
Camazine MN, Karam O, Colvin R, Leteurtre S, Demaret P, Tucci M, Muszynski JA, Stanworth S, Spinella PC. Outcomes Related to the Use of Frozen Plasma or Pooled Solvent/Detergent-Treated Plasma in Critically Ill Children*. Pediatric Critical Care Medicine 2017, 18: e215-e223. PMID: 28350560, DOI: 10.1097/pcc.0000000000001149.Peer-Reviewed Original ResearchConceptsSolvent detergent plasmaPlasma 24 hoursICU mortalityIll childrenPlasma transfusionStudy groupHours groupPretransfusion international normalized ratioSolvent/detergent-treated plasmaCritically Ill ChildrenInternational normalized ratioHypothesis-generating dataMultivariable logistic regressionIllness scoresImproved survivalMedian ageAdjusted analysisNormalized ratioPrimary indicationIndependent associationFrozen plasmaObservational studyPlasma useLactate valuesPatientsRapid detection and ruling out of neonatal sepsis by PCR coupled with Electrospray Ionization Mass Spectrometry (PCR/ESI-MS)
Delcò C, Karam O, Pfister R, Gervaix A, Renzi G, Emonet S, Schrenzel J, Posfay-Barbe KM. Rapid detection and ruling out of neonatal sepsis by PCR coupled with Electrospray Ionization Mass Spectrometry (PCR/ESI-MS). Early Human Development 2017, 108: 17-22. PMID: 28343091, DOI: 10.1016/j.earlhumdev.2017.03.004.Peer-Reviewed Original ResearchConceptsNegative predictive valuePCR/ESI-MSBlood culturesPredictive valueNeonatal sepsisGood negative predictive valueProspective observational studyBlood culture resultsInitiation of antibioticsPositive blood culturesConventional blood culturePositive predictive valueEmpiric antibioticsConsecutive neonatesAdverse eventsClinical suspicionMedian ageNeonatal populationObservational studySepsisBlood samplesEarly reassessmentImportant causeCulture resultsBacterial infections
2016
Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions
Karam O, Demaret P, Duhamel A, Shefler A, Spinella PC, Stanworth SJ, Tucci M, Leteurtre S, for the PlasmaTV investigators. Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions. Annals Of Intensive Care 2016, 6: 98. PMID: 27714707, PMCID: PMC5053948, DOI: 10.1186/s13613-016-0197-6.Peer-Reviewed Original ResearchPELOD-2 scorePlasma transfusionIll childrenDay 1General pediatric intensive care unit populationPediatric Logistic Organ Dysfunction-2 scorePediatric intensive care unit populationIntensive care unit populationSpecific subpopulationsOrgan dysfunction scoreProspective observational studyHosmer-Lemeshow testObserved mortality ratePELOD-2Dysfunction scoreClinical outcomesOrgan failureResultsFour hundredClinical trialsScore scoresSerial evaluationAncillary studiesObservational studyTransfusionUnit populationKetosis After Cardiopulmonary Bypass in Children Is Associated With an Inadequate Balance Between Oxygen Transport and Consumption*
Klee P, Arni D, Saudan S, Schwitzgebel VM, Sharma R, Karam O, Rimensberger PC. Ketosis After Cardiopulmonary Bypass in Children Is Associated With an Inadequate Balance Between Oxygen Transport and Consumption*. Pediatric Critical Care Medicine 2016, 17: 852-859. PMID: 27472253, DOI: 10.1097/pcc.0000000000000880.Peer-Reviewed Original ResearchConceptsIndependent risk factorPICU admissionCardiopulmonary bypassInsulin treatmentCardiac surgeryRisk factorsPostoperative blood glucose levelsProspective observational studyPatients 6 monthsSubset of patientsSubgroup of patientsVenous oxygen saturationTight glycemic controlBlood glucose levelsGlycemic controlTertiary PICUGlucose intakeWorse outcomesPatient outcomesHigh prevalenceObservational studyGlucose levelsOxygen saturationMetabolic constellationAdmissionAccuracy of Transcutaneous Carbon Dioxide Measurement in Premature Infants
Janaillac M, Labarinas S, Pfister RE, Karam O. Accuracy of Transcutaneous Carbon Dioxide Measurement in Premature Infants. Critical Care Research And Practice 2016, 2016: 8041967. PMID: 27375901, PMCID: PMC4916268, DOI: 10.1155/2016/8041967.Peer-Reviewed Original ResearchPremature infantsBlood partial pressureBlood pCO2 valuesGestational ageBlood PCO2Tertiary neonatal intensive care unitNeonatal intensive care unitConsecutive premature infantsRetrospective observational studyWeeks gestational ageIntensive care unitTranscutaneous carbon dioxide measurementsCare unitCerebral lesionsObservational studyTranscutaneous methodCarbon dioxide valuesInfantsR correlationsTcPCO2Transcutaneous valuesPCO2 valuesPearson r correlationsPCO2Carbon dioxide measurements
2014
Transfusions de plasma en réanimation pédiatrique
Labarinas S, Arni D, Karam O. Transfusions de plasma en réanimation pédiatrique. Médecine Intensive Réanimation 2014, 23: 455-462. DOI: 10.1007/s13546-014-0900-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAbnormal coagulation testsPlasma transfusionCoagulation testsRed blood cell transfusionNon-bleeding patientsBlood cell transfusionIntensive care unitRecent epidemiological studiesCell transfusionIll adultsIll patientsCare unitRéanimation pédiatriqueFrequent treatmentObservational studyCurrent evidenceEpidemiological studiesTransfusionCoagulation factorsVolume replacementPatientsTreatmentMost expertsIndicationsBleeding
2013
Plasma in the PICU: why and when should we transfuse?
Labarinas S, Arni D, Karam O. Plasma in the PICU: why and when should we transfuse? Annals Of Intensive Care 2013, 3: 16. PMID: 23725411, PMCID: PMC3698065, DOI: 10.1186/2110-5820-3-16.Peer-Reviewed Original ResearchAbnormal coagulation testsPlasma transfusionCoagulation testsRed blood cell transfusionBlood cell transfusionIntensive care unitRecent epidemiological studiesCell transfusionIll adultsIll patientsCare unitFrequent treatmentObservational studyCurrent evidenceEpidemiological studiesCoagulation factorsTransfusionVolume replacementPatientsTreatmentMost expertsIndicationsPICUBleedingMorbidity
2010
Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study
Karam O, Tucci M, Bateman ST, Ducruet T, Spinella PC, Randolph AG, Lacroix J. Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study. Critical Care 2010, 14: r57. PMID: 20377853, PMCID: PMC2887178, DOI: 10.1186/cc8953.Peer-Reviewed Original ResearchConceptsPediatric intensive care unitMultiple organ dysfunction syndromeRed blood cell unitsOrgan dysfunction syndromeDysfunction syndromeIll childrenPICU lengthClinical outcomesOdds ratioObservational studyMultiple logistic regression modelProspective observational studyWorse clinical outcomesPrimary outcome measureIntensive care unitNorth American centersCell unitsLogistic regression modelsSecondary outcomesConsecutive patientsOrgan dysfunctionCare unitMedian lengthProspective studyClinical impact