2024
Associations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort
Rivara A, Russell E, Carlson J, Pomer A, Naseri T, Reupena M, Manna S, Viali S, Minster R, Weeks D, DeLany J, Kershaw E, McGarvey S, Hawley N. Associations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort. PLOS ONE 2024, 19: e0302643. PMID: 38829901, PMCID: PMC11146712, DOI: 10.1371/journal.pone.0302643.Peer-Reviewed Original ResearchConceptsType 2 diabetesAllele of rs373863828Body mass indexFasting glucoseAdult SamoansDevelopment of type 2 diabetesOdds of type 2 diabetesReduction of modifiable risk factorsRs373863828 genotypeAssociated with higher body mass indexType 2 diabetes developmentGlucose rate of changeMass indexHousehold asset scoreUrbanization of residenceHigher body mass indexRisk factorsModifiable risk factorsRate of changeBaseline variablesMultivariate linear regressionPhysical activityDiabetes preventionType 2 diabetes mellitusSmoking status
2023
Association between age at menarche and cardiometabolic risk among Samoan adults
Oyama S, Duckham R, Pomer A, Rivara A, Kershaw E, Wood A, Fidow U, Naseri T, Reupena M, Viali S, McGarvey S, Hawley N. Association between age at menarche and cardiometabolic risk among Samoan adults. American Journal Of Human Biology 2023, 36: e23982. PMID: 37668413, PMCID: PMC10845161, DOI: 10.1002/ajhb.23982.Peer-Reviewed Original ResearchConceptsCardiometabolic riskOne-year increaseSubsequent cardiometabolic riskOdds of hypertensionHigher total cholesterolOdds of diabetesOdds of obesityEarly life exposureFat-free massCardiometabolic morbiditySerum lipidsBlood pressureMedian ageMetabolic syndromeTotal cholesterolProspective studyChildhood adiposityInsulin resistanceObesity prevalenceLife exposureSamoan adultsLean massEarly menarcheLogistic regressionMenarche
2022
Validity of anthropometric equation‐based estimators of fat mass in Samoan adults
Heinsberg L, Hawley N, Duckham R, Pomer A, Rivara A, Naseri T, Reupena M, Weeks D, McGarvey S, Minster R. Validity of anthropometric equation‐based estimators of fat mass in Samoan adults. American Journal Of Human Biology 2022, 35: e23838. PMID: 36428275, PMCID: PMC10023273, DOI: 10.1002/ajhb.23838.Peer-Reviewed Original Research
2021
C‐reactive protein in adult Samoans: Population variation and physiological correlates
Rivara AC, Corley M, Choy CC, Duckham RL, Pomer A, Reupena MS, Viali S, Naseri T, Kershaw EE, Crouter SE, McGarvey ST, Bribiescas RG, Valeggia C, Hawley NL. C‐reactive protein in adult Samoans: Population variation and physiological correlates. American Journal Of Human Biology 2021, 34: e23646. PMID: 34260111, PMCID: PMC8758804, DOI: 10.1002/ajhb.23646.Peer-Reviewed Original ResearchMeSH KeywordsAdiposityAdultBody Mass IndexC-Reactive ProteinFemaleHumansInsulin ResistanceMaleMiddle AgedObesityConceptsC-reactive proteinBody mass indexCardiometabolic disease riskMeasures of adiposityAdult SamoansCRP correlateDisease riskSerum C-reactive proteinMeasures of BMICardiometabolic risk markersPercent body fatSex-dependent associationsCardiometabolic markersCardiometabolic riskCRP quartileMass indexUnadjusted analysesRisk markersBody fatKruskal-Wallis testAdiposityPacific Islander populationsSpearman rank correlationFirst examinationRank correlation
2020
Assessing the impact of high blood pressure referrals on hypertension awareness and management, BMI, and blood pressure values in adult Samoans 2010–2019
Rivara AC, Pomer A, Naseri T, Reupena MS, Viali S, Choy CC, McGarvey ST, Hawley NL. Assessing the impact of high blood pressure referrals on hypertension awareness and management, BMI, and blood pressure values in adult Samoans 2010–2019. Annals Of Human Biology 2020, 47: 597-601. PMID: 32924611, PMCID: PMC8180238, DOI: 10.1080/03014460.2020.1822914.Peer-Reviewed Original ResearchConceptsElevated blood pressureBody mass indexBlood pressureNon-communicable diseasesMedication usePhysician diagnosisRisk factorsLong-term health improvementsHypertension medication useBlood pressure valuesNCD risk factorsHypertension controlCardiometabolic healthHypertension awarenessMass indexAdult SamoansHealth referralsDisease burdenReduced oddsBP valuesSamoan adultsReferralLogistic regressionHealth sector actorsMcNemar testGenome-wide association studies in Samoans give insight into the genetic architecture of fasting serum lipid levels
Carlson JC, Weeks DE, Hawley NL, Sun G, Cheng H, Naseri T, Reupena M, Tuitele J, Deka R, McGarvey ST, Minster RL. Genome-wide association studies in Samoans give insight into the genetic architecture of fasting serum lipid levels. Journal Of Human Genetics 2020, 66: 111-121. PMID: 32759990, PMCID: PMC7785639, DOI: 10.1038/s10038-020-0816-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultApolipoprotein A-IApolipoproteins ECholesterol Ester Transfer ProteinsCholesterol, HDLCholesterol, LDLCohort StudiesFastingFemaleGenetic MarkersGenome-Wide Association StudyHumansLipid MetabolismLipidsMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociSamoaTriglyceridesConceptsGenome-wide association studiesGenetic architectureAssociation studiesGenome-wide significant associationDifferent association signalsUnique population historyPopulation bottlenecksLipid lociPopulation historyAssociation signalsSuggestive associationRab21Current understandingMGAT1Association of variantsReplication cohortLipidsBiological foundationsVariantsLociLow-density lipoproteinInsightsPopulationLipid levelsHigh-density lipoprotein
2014
Epigenetic patterns in successful weight loss maintainers: a pilot study
Huang Y, Maccani J, Hawley N, Wing R, Kelsey K, McCaffery J. Epigenetic patterns in successful weight loss maintainers: a pilot study. International Journal Of Obesity 2014, 39: 865-868. PMID: 25520250, PMCID: PMC4422763, DOI: 10.1038/ijo.2014.213.Peer-Reviewed Original ResearchConceptsOB individualsSuccessful weight loss maintainersBrain-derived neurotrophic factorBehavioral weight loss interventionWeight loss maintainersWeight loss interventionMyelin protein zeroLoss interventionNormal weightNeurotrophic factorObese individualsRyanodine receptor 1Weight statusAnimal modelsCalorie restrictionReceptor 1NW individualsPilot studyWeight lossProtein zeroMethylation patternsEpigenome-wide analysisHuman subjectsEpigenetic patternsDNA methylation changes