2018
Tracking virus outbreaks in the twenty-first century
Grubaugh ND, Ladner JT, Lemey P, Pybus OG, Rambaut A, Holmes EC, Andersen KG. Tracking virus outbreaks in the twenty-first century. Nature Microbiology 2018, 4: 10-19. PMID: 30546099, PMCID: PMC6345516, DOI: 10.1038/s41564-018-0296-2.Peer-Reviewed Original ResearchConceptsWorld Health OrganizationInfectious disease epidemiologyEconomic burdenInfectious diseasesVirus sequencingSubstantial mortalityHealth OrganizationMajor epidemicsUnknown pathogensVirus outbreakDisease epidemiologyPotential causesOutbreak virusesDisease XInitial detectionVirusOutbreakHypothetical outbreakMorbidityCase dataEpidemiologyMortalityDiseaseHuman population
2016
Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013–2016 Epidemic
Diehl WE, Lin AE, Grubaugh ND, Carvalho LM, Kim K, Kyawe PP, McCauley SM, Donnard E, Kucukural A, McDonel P, Schaffner SF, Garber M, Rambaut A, Andersen KG, Sabeti PC, Luban J. Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013–2016 Epidemic. Cell 2016, 167: 1088-1098.e6. PMID: 27814506, PMCID: PMC5115602, DOI: 10.1016/j.cell.2016.10.014.Peer-Reviewed Original ResearchMeSH KeywordsAfrica, WesternAmino Acid SubstitutionAnimalsCallithrixCarrier ProteinsCheirogaleidaeCytoplasmEbolavirusHemorrhagic Fever, EbolaHumansIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsNiemann-Pick C1 ProteinProtein Conformation, alpha-HelicalViral Envelope ProteinsVirionVirulenceConceptsHuman dendritic cellsIncreased infectivityEbola virus disease epidemicHuman hostEbola virus glycoproteinDendritic cellsHuman transmission eventsEVD epidemicEBOV-GPDisease severityViral mutationsViral infectivityPrimate cellsIntrinsic infectivityTransmission eventsInfectivityEpidemicVirus glycoproteinDisease epidemicsCellsNonsynonymous mutationsMutationsOutbreakHigh frequencyMortality