2024
Rainfall events and daily mortality across 645 global locations: two stage time series analysis
He C, Breitner-Busch S, Huber V, Chen K, Zhang S, Gasparrini A, Bell M, Kan H, Royé D, Armstrong B, Schwartz J, Sera F, Vicedo-Cabrera A, Honda Y, Jaakkola J, Ryti N, Kyselý J, Guo Y, Tong S, de'Donato F, Michelozzi P, Coelho M, Saldiva P, Lavigne E, Orru H, Indermitte E, Pascal M, Goodman P, Zeka A, Kim Y, Diaz M, Arellano E, Overcenco A, Klompmaker J, Rao S, Palomares A, Carrasco G, Seposo X, Pereira da Silva S, Madureira J, Holobaca I, Scovronick N, Acquaotta F, Kim H, Lee W, Hashizume M, Tobias A, Íñiguez C, Forsberg B, Ragettli M, Guo Y, Pan S, Osorio S, Li S, Zanobetti A, Dang T, Van Dung D, Schneider A. Rainfall events and daily mortality across 645 global locations: two stage time series analysis. The BMJ 2024, 387: e080944. PMID: 39384295, DOI: 10.1136/bmj-2024-080944.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesCause of DeathGlobal HealthHumansMortalityRainRespiratory Tract DiseasesTime FactorsConceptsYear return periodReturn periodsRainfall eventsVegetation coverageCharacteristics of daily rainfallDaily rainfall intensityDaily rainfallRainfall intensityRespiratory mortalityClimate typesRainfallLocal climateIntensity indexGlobal scaleTime series analysisMortality riskRelative riskAssociated with respiratory mortalityDaily mortalityDaily mortality dataClimateEstimate mortality riskIncreased relative riskSeries analysisGlobal locationsAll-cause, cardiovascular, and respiratory mortality and wildfire-related ozone: a multicountry two-stage time series analysis
Chen G, Guo Y, Yue X, Xu R, Yu W, Ye T, Tong S, Gasparrini A, Bell M, Armstrong B, Schwartz J, Jaakkola J, Lavigne E, Saldiva P, Kan H, Royé D, Urban A, Vicedo-Cabrera A, Tobias A, Forsberg B, Sera F, Lei Y, Abramson M, Li S, Network M, Abrutzky R, Alahmad B, Ameling C, Åström C, Breitner S, Carrasco-Escobar G, de Sousa Zanotti Stagliorio Coêlho M, Colistro V, Correa P, Dang T, de'Donato F, Van Dung, Entezari A, Garcia S, Garland R, Goodman P, Guo Y, Hashizume M, Holobaca I, Honda Y, Houthuijs D, Hurtado-Díaz M, Íñiguez C, Katsouyanni K, Kim H, Kyselý J, Lee W, Maasikmets M, Madureira J, Mayvaneh F, Nunes B, Orru H, Ortega N, Overcenco A, Pan S, Pascal M, Ragettli M, Rao S, Ryti N, Samoli E, Schneider A, Scovronick N, Seposo X, Stafoggia M, De la Cruz Valencia C, Zanobetti A, Zeka A. All-cause, cardiovascular, and respiratory mortality and wildfire-related ozone: a multicountry two-stage time series analysis. The Lancet Planetary Health 2024, 8: e452-e462. PMID: 38969473, DOI: 10.1016/s2542-5196(24)00117-7.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsAir PollutionCardiovascular DiseasesEnvironmental ExposureGlobal HealthHumansOzoneRespiratory Tract DiseasesWildfiresConceptsRespiratory mortalityImpact of wildfiresDaily respiratory mortalityDaily cardiovascular mortalityTwo-stage time-series analysisChemical transport modelWildfire activityDaily mortality ratesDaily concentrationsDaily mortalityStudy locationRespiratory deathsWildfireManagement strategiesSource of tropospheric ozoneTransport modelTropospheric ozoneGlobal levelLocation levelMulti-cityRegional levelMortality fractionsEffective riskSouth AmericaCentral AmericaGlobal and Regional Cardiovascular Mortality Attributable to Nonoptimal Temperatures Over Time
Hundessa S, Huang W, Zhao Q, Wu Y, Wen B, Alahmad B, Armstrong B, Gasparrini A, Sera F, Tong S, Madureira J, Kyselý J, Schwartz J, Vicedo-Cabrera A, Hales S, Johnson A, Li S, Guo Y, Jaakkola J, Ryti N, Urban A, Tobias A, Royé D, Lavigne E, Ragettli M, Åström C, Raz R, Pascal M, Kan H, Goodman P, Zeka A, Hashizume M, Diaz M, Seposo X, Nunes B, Kim H, Lee W, Íñiguez C, Guo Y, Pan S, Zanobetti A, Dang T, Van Dung, Schneider A, Entezari A, Analitis A, Forsberg B, Ameling C, Houthuijs D, Indermitte E, Mayvaneh F, Acquaotta F, de'Donato F, Carrasco-Escobar G, Orru H, Katsouyanni K, de Sousa Zanotti Stagliorio Coelho M, Ortega N, Scovronick N, Michelozzi P, Correa P, Saldiva P, Abrutzky R, Osorio S, Colistro V, Huber V, Honda Y, Kim Y, Bell M, Xu R, Yang Z, Roradeh H, Arellano E, Rao S, Chua P, da Silva S, da Silva S, De la Cruz Valencia C. Global and Regional Cardiovascular Mortality Attributable to Nonoptimal Temperatures Over Time. Journal Of The American College Of Cardiology 2024, 83: 2276-2287. PMID: 38839202, DOI: 10.1016/j.jacc.2024.03.425.Peer-Reviewed Original ResearchConceptsCardiovascular deathCardiovascular mortalityExcess mortality ratesCardiovascular mortality riskMultivariate meta-regression modelTemperature-mortality associationsMeta-regression modelsTemperature-related deathsMortality burdenMortality riskEffect estimatesHeat-related deathsSub-Saharan AfricaMortality attributesTemporal trendsCold-related deathsMortality rateGlobal assessmentSub-SaharanInvestigated spatiotemporal trendsDeath ratioMortalityBurdenComprehensive global assessmentDeathLong-term exposure to PM2.5 and mortality in a national cohort in South Korea: effect modification by community deprivation, medical infrastructure, and greenness
Byun G, Kim S, Choi Y, Kim A, Team A, Lee J, Bell M. Long-term exposure to PM2.5 and mortality in a national cohort in South Korea: effect modification by community deprivation, medical infrastructure, and greenness. BMC Public Health 2024, 24: 1266. PMID: 38720292, PMCID: PMC11080206, DOI: 10.1186/s12889-024-18752-y.Peer-Reviewed Original ResearchConceptsLong-term exposure to PM2.5Exposure to PM2.5Respiratory mortalityCirculatory mortalityEffect of long-term exposure to PM2.5National Health Insurance Service-National Sample CohortLong-term PM2.5 exposureAssociated with respiratory mortalityReduce health disparitiesMedical infrastructureNon-accidentalCommunity-level deprivationCommunity-level factorsCommunity-level characteristicsPotential modifying effectPublic health outcomesNationwide cohort studyIncreased mortality riskCox proportional-hazards modelDeprivation indexHealth disparitiesCommunity deprivationHigh deprivationHealth outcomesEffect modification
2023
Health disparities among older adults following tropical cyclone exposure in Florida
Burrows K, Anderson G, Yan M, Wilson A, Sabath M, Son J, Kim H, Dominici F, Bell M. Health disparities among older adults following tropical cyclone exposure in Florida. Nature Communications 2023, 14: 2221. PMID: 37076480, PMCID: PMC10115860, DOI: 10.1038/s41467-023-37675-7.Peer-Reviewed Original ResearchEffects of heat waves on cardiovascular and respiratory mortality in Rio de Janeiro, Brazil
Silveira I, Cortes T, Bell M, Junger W. Effects of heat waves on cardiovascular and respiratory mortality in Rio de Janeiro, Brazil. PLOS ONE 2023, 18: e0283899. PMID: 37000782, PMCID: PMC10065291, DOI: 10.1371/journal.pone.0283899.Peer-Reviewed Original ResearchMeSH KeywordsAgedBrazilCardiovascular DiseasesCross-Over StudiesFemaleHot TemperatureHumansMortalityRespiratory Tract DiseasesTemperatureConceptsRespiratory mortalityOdds ratioDistributed lag non-linear modelCardiovascular mortalityIndividual-level exposuresHeat wave intensityCase-crossover studyConditional logistic regressionMunicipal Health DepartmentHeat wavesEffects of heat wavesHealth impacts of heat wavesHealth departmentsHealth resourcesDeath dataOlder peopleLow-incomeEffect estimatesOlder womenDefinition of heat wavesLogistic regressionEpidemiological evidenceMorbidity outcomesHeat wave daysHealth impactsShort-Term Association between Sulfur Dioxide and Mortality: A Multicountry Analysis in 399 Cities
O’Brien E, Masselot P, Sera F, Roye D, Breitner S, Ng C, de Sousa Zanotti Stagliorio Coelho M, Madureira J, Tobias A, Vicedo-Cabrera A, Bell M, Lavigne E, Kan H, Gasparrini A, Network M. Short-Term Association between Sulfur Dioxide and Mortality: A Multicountry Analysis in 399 Cities. Environmental Health Perspectives 2023, 131: 037002. PMID: 36883823, PMCID: PMC9994178, DOI: 10.1289/ehp11112.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsAir PollutionCardiovascular DiseasesCitiesEnvironmental ExposureEnvironmental PollutantsHumansMortalityNitrogen DioxideParticulate MatterSulfur DioxideConceptsExposure-response relationshipRelative riskShort-term associationsShort-term exposureRR of mortalitySteeper exposure-response relationshipsBi-pollutant modelsIndependent mortality riskSubstantial excess mortalityWorld Health Organization (WHO) guideline limitsSignificant positive associationEpidemiological evidenceExcess mortalityMortality riskAdvanced study designsExcess deathsMortality fractionsSecondary analysisStudy designMortalityStudy periodExposure levelsPotential roleDaily concentrationsDaily mortality
2022
Associations Between Extreme Temperatures and Cardiovascular Cause-Specific Mortality: Results From 27 Countries
Alahmad B, Khraishah H, Royé D, Vicedo-Cabrera A, Guo Y, Papatheodorou S, Achilleos S, Acquaotta F, Armstrong B, Bell M, Pan S, de Sousa Zanotti Stagliorio Coelho M, Colistro V, Dang T, Van Dung D, De' Donato F, Entezari A, Guo Y, Hashizume M, Honda Y, Indermitte E, Íñiguez C, Jaakkola J, Kim H, Lavigne E, Lee W, Li S, Madureira J, Mayvaneh F, Orru H, Overcenco A, Ragettli M, Ryti N, Saldiva P, Scovronick N, Seposo X, Sera F, Silva S, Stafoggia M, Tobias A, Garshick E, Bernstein A, Zanobetti A, Schwartz J, Gasparrini A, Koutrakis P. Associations Between Extreme Temperatures and Cardiovascular Cause-Specific Mortality: Results From 27 Countries. Circulation 2022, 147: 35-46. PMID: 36503273, PMCID: PMC9794133, DOI: 10.1161/circulationaha.122.061832.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesCause of DeathCold TemperatureDeathHeart FailureHot TemperatureHumansMortalityMyocardial IschemiaStrokeTemperatureConceptsMinimum mortality temperatureExcess deathsIschemic heart diseaseCardiovascular causesCardiovascular deathCause-specific mortalityCardiovascular health needsCase-crossover modelsMortality temperatureAssociated with higher riskHeart diseaseRisk of mortalityCold daysHealth needsMortality associationsTemperature percentileData collection protocolsExtreme temperaturesDeath proportionCardiovascular conditionsHeart failureCardiovascular diseaseCold temperaturesReanalysis modelsHigh risk
2017
Associations between mortality and prolonged exposure to elevated particulate matter concentrations in East Asia
Kim SE, Bell ML, Hashizume M, Honda Y, Kan H, Kim H. Associations between mortality and prolonged exposure to elevated particulate matter concentrations in East Asia. Environment International 2017, 110: 88-94. PMID: 29097051, DOI: 10.1016/j.envint.2017.10.010.Peer-Reviewed Original ResearchMeSH KeywordsAgedAir PollutantsAir PollutionAsiaBronchiolitisCardiovascular DiseasesCitiesFemaleHumansMaleMortalityParticulate MatterPublic HealthRisk FactorsMortality burden of diurnal temperature range and its temporal changes: A multi-country study
Lee W, Bell ML, Gasparrini A, Armstrong BG, Sera F, Hwang S, Lavigne E, Zanobetti A, Coelho MSZS, Saldiva PHN, Osorio S, Tobias A, Zeka A, Goodman PG, Forsberg B, Rocklöv J, Hashizume M, Honda Y, Guo YL, Seposo X, Van Dung D, Dang TN, Tong S, Guo Y, Kim H. Mortality burden of diurnal temperature range and its temporal changes: A multi-country study. Environment International 2017, 110: 123-130. PMID: 29089167, DOI: 10.1016/j.envint.2017.10.018.Peer-Reviewed Original ResearchDoes a lag-structure of temperature confound air pollution-lag-response relation? Simulation and application in 7 major cities, Korea (1998–2013)
Kim H, Bell ML, Lee JT. Does a lag-structure of temperature confound air pollution-lag-response relation? Simulation and application in 7 major cities, Korea (1998–2013). Environmental Research 2017, 159: 531-538. PMID: 28888197, DOI: 10.1016/j.envres.2017.08.047.Peer-Reviewed Original ResearchParticulate Matter and Risk of Hospital Admission in the Kathmandu Valley, Nepal: A Case-Crossover Study
Gurung A, Son JY, Bell ML. Particulate Matter and Risk of Hospital Admission in the Kathmandu Valley, Nepal: A Case-Crossover Study. American Journal Of Epidemiology 2017, 186: 573-580. PMID: 28911012, DOI: 10.1093/aje/kwx135.Peer-Reviewed Original ResearchConceptsHealth burdenTime-stratified case-crossover analysisRisk of hospitalizationSubstantial health burdenInpatient hospitalization dataCase-crossover studyPotential effect modifiersCase-crossover analysisMajority of evidenceHospital admissionEffect modificationCardiovascular admissionsHospitalization dataM3 increaseEffect modifiersMajor hospitalsSocioeconomic statusHospitalizationAdmissionHuman health burdenKathmandu ValleyCentral data collection systemBurdenAir pollutionAerodynamic diameterAssociations between Greenness, Impervious Surface Area, and Nighttime Lights on Biomarkers of Vascular Aging in Chennai, India
Lane KJ, Stokes EC, Seto KC, Thanikachalam S, Thanikachalam M, Bell ML. Associations between Greenness, Impervious Surface Area, and Nighttime Lights on Biomarkers of Vascular Aging in Chennai, India. Environmental Health Perspectives 2017, 125: 087003. PMID: 28886599, PMCID: PMC5783666, DOI: 10.1289/ehp541.Peer-Reviewed Original ResearchConceptsFlow-mediated dilatationCentral pulse pressureEarly vascular agingBody mass indexCardiovascular diseaseRisk factorsLower flow-mediated dilatationCVD risk factorsDiastolic blood pressureInterquartile range decreaseMultivariable regression modelsCross-sectional analysisElevated SBPBlood pressureMass indexSmoking statusPulse pressureVascular agingPhysical activityIntervention studiesEnergy intakeSemiurban regionStudy participantsResidential exposureEndovascular diseaseTemporal Changes in Mortality Related to Extreme Temperatures for 15 Cities in Northeast Asia: Adaptation to Heat and Maladaptation to Cold
Chung Y, Noh H, Honda Y, Hashizume M, Bell ML, Guo YL, Kim H. Temporal Changes in Mortality Related to Extreme Temperatures for 15 Cities in Northeast Asia: Adaptation to Heat and Maladaptation to Cold. American Journal Of Epidemiology 2017, 185: 907-913. PMID: 28444109, PMCID: PMC5860040, DOI: 10.1093/aje/kww199.Peer-Reviewed Original Research
2016
Airborne Fine Particles and Risk of Hospital Admissions for Understudied Populations: Effects by Urbanicity and Short-Term Cumulative Exposures in 708 U.S. Counties
Bravo MA, Ebisu K, Dominici F, Wang Y, Peng RD, Bell ML. Airborne Fine Particles and Risk of Hospital Admissions for Understudied Populations: Effects by Urbanicity and Short-Term Cumulative Exposures in 708 U.S. Counties. Environmental Health Perspectives 2016, 125: 594-601. PMID: 27649448, PMCID: PMC5381978, DOI: 10.1289/ehp257.Peer-Reviewed Original Research
2015
Brief Report
Bell ML, Son JY, Peng RD, Wang Y, Dominici F. Brief Report. Epidemiology 2015, 26: 575-579. PMID: 25906368, PMCID: PMC4452416, DOI: 10.1097/ede.0000000000000310.Peer-Reviewed Original ResearchConceptsRespiratory tract infectionsCause of hospitalizationRisk of heartSame-day PM2.5Cardiovascular causesTract infectionsRespiratory hospitalizationsMedicare beneficiariesHospitalizationWomenAdmissionAmbient monitorsMenRiskAssociationUS countiesHeartCauseBrief reportCardiovascularStrong evidenceInfectionPoint estimatesAmbient Coarse Particulate Matter and Hospital Admissions in the Medicare Cohort Air Pollution Study, 1999–2010
Powell H, Krall JR, Wang Y, Bell ML, Peng RD. Ambient Coarse Particulate Matter and Hospital Admissions in the Medicare Cohort Air Pollution Study, 1999–2010. Environmental Health Perspectives 2015, 123: 1152-1158. PMID: 25872223, PMCID: PMC4629736, DOI: 10.1289/ehp.1408720.Peer-Reviewed Original ResearchConceptsYears of ageEmergency hospitalizationHospital admissionM3 increaseMedicare enrolleesRespiratory-related hospitalizationsTwo-stage Bayesian hierarchical modelSignificant increaseShort-term associationsCardiovascular hospitalizationMorbidity outcomesCardiovascular diseaseRespiratory diseaseHospitalizationShort-term exposureAmbient Coarse Particulate MatterPoisson log-linear regression modelsLog-linear regression modelCoarse particulate matterAdmissionAmbient coarseAssociationNumber of studiesDiseaseEnrolleesAir pollution and mortality in São Paulo, Brazil: Effects of multiple pollutants and analysis of susceptible populations
Bravo MA, Son J, de Freitas CU, Gouveia N, Bell ML. Air pollution and mortality in São Paulo, Brazil: Effects of multiple pollutants and analysis of susceptible populations. Journal Of Exposure Science & Environmental Epidemiology 2015, 26: 150-161. PMID: 25586330, DOI: 10.1038/jes.2014.90.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAir PollutantsAir PollutionBrazilCarbon MonoxideCardiovascular DiseasesCase-Control StudiesDeath CertificatesEnvironmental MonitoringFemaleHumansLogistic ModelsMaleMiddle AgedNitrogen DioxideOzoneParticle SizeParticulate MatterRespiratory Tract DiseasesRisk FactorsSex DistributionSocioeconomic FactorsSulfur DioxideConceptsTime of deathSocioeconomic statusTime-stratified case-crossover analysisCase-crossover analysisResidential socioeconomic statusEducation groupHospital deathCardiovascular mortalityNon-accidental mortalityRespiratory mortalityMortality riskHigh education groupEvidence of differencesSignificant associationMortalityEffect estimatesDeathMortality effectsSusceptible populationHealth impactsAmbient monitorsIndividual-level health dataAir pollutionHealth dataAerodynamic diameter
2013
Associations of PM2.5 Constituents and Sources with Hospital Admissions: Analysis of Four Counties in Connecticut and Massachusetts (USA) for Persons ≥ 65 Years of Age
Bell ML, Ebisu K, Leaderer BP, Gent JF, Lee HJ, Koutrakis P, Wang Y, Dominici F, Peng RD. Associations of PM2.5 Constituents and Sources with Hospital Admissions: Analysis of Four Counties in Connecticut and Massachusetts (USA) for Persons ≥ 65 Years of Age. Environmental Health Perspectives 2013, 122: 138-144. PMID: 24213019, PMCID: PMC3915260, DOI: 10.1289/ehp.1306656.Peer-Reviewed Original Research
2012
Assessment of the health impacts of particulate matter characteristics.
Bell ML. Assessment of the health impacts of particulate matter characteristics. Research Report 2012, 5-38. PMID: 22393584.Peer-Reviewed Original ResearchConceptsHealth effect estimatesCardiovascular hospital admissionsHospital admissionEffect estimatesMortality effect estimatesHealth effectsCause of hospitalizationAir pollution-related health effectsInterquartile range increasePollution-related health effectsRespiratory hospital admissionsAdverse health effectsHealth effects dataCardiovascular hospitalizationRespiratory hospitalizationsCardiovascular admissionsHigh prevalenceHospitalizationAerodynamic diameterAdmissionCommunity-level variablesObserved associationsSocioeconomic statusHealth impactsPM toxicity