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INFORMATION FOR

    Michael H Nathanson, MD, PhD

    Gladys Phillips Crofoot Professor of Medicine (Digestive Diseases) and Professor of Cell Biology
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    Additional Titles

    Co-Director, Yale Liver Center, Digestive Diseases

    Director, Center for Cell and Molecular Imaging

    Contact Info

    michael.nathanson@yale.edu
    203.785.5110

    Yale School of Medicine

    Department of Medicine (Digestive Diseases), PO Box 208019

    New Haven, CT 06520-8019

    United States

    About

    Titles

    Gladys Phillips Crofoot Professor of Medicine (Digestive Diseases) and Professor of Cell Biology

    Co-Director, Yale Liver Center, Digestive Diseases; Director, Center for Cell and Molecular Imaging

    Appointments

    Other Departments & Organizations

    Education & Training

    Postdoctoral Fellow
    Yale University (1990)
    Resident
    Columbia-Presbyterian Medical Center (1988)
    MD
    Case Western Reserve Univ (1985)
    PhD
    Case Western Reserve Univ (1983)
    MS
    Massachusetts Institute of Technology (1977)
    BS
    University of California, Berkeley (1976)

    Research

    Overview

    • NIH P01 DK57751 (PI: M.H. Nathanson) 04/01/01-04/30/21 Title: Regulation of liver by nuclear calcium signaling Goals: The major goals of this project are to determine the mechanisms by which calcium is regulated in the nucleus of hepatocytes, and to determine the functional effects of nuclear calcium signals in liver. Dr. Nathanson directs Project 1 and the Administrative and Cell Imaging cores of this PPG.
    • NIH P30 DK34989 (PI: M.H. Nathanson) 09/01/84-08/31/20 (NCE pending) Title: Digestive Diseases Research Core Center (Yale Liver Center) Goals: Dr. Nathanson is Director of the Liver Center as well as of the Morphology and Administrative Core components of the Center. The major goals of the Morphology Core are to provide a multidisciplinary center where the research focus is liver structure, function and disease.
    • NIH R01 DK114041 (PI: M.H. Nathanson) 02/01/18-03/31/23 Title: Ca2+ waves in hepatocytes: Mechanisms and effects Goals: The major goals of this project are to determine the mechanisms by which the type 2 InsP3 receptor regulates calcium-mediated bile secretion by hepatocytes, and to determine the role that loss or mis-localization of this receptor plays in the pathogenesis of cholestatic liver disease.
    • NIH R01 DK112797 (PI: M.H. Nathanson) 09/01/17-08/31/22 Title: Molecular regulation of cholestasis in cholangiocytes. Goals: Major goals are to understand the role of type 3 inositol trisphosphate receptor function in cholestatic liver disease
    • NIH T32 DK007356 (PI: M.H. Nathanson) 7/1/84-6/30/24 Title: Investigative Training in Hepatology. Goals: This training grant provides 1) laboratory research training for physicians who have completed clinical training in Gastroenterology and are in preparation for careers as independent investigators in academic Hepatology and research training for recent Ph.D. graduates to prepare them for careers as independent investigators in basic liver-related research.

    Medical Research Interests

    Calcium Signaling; Cell Biology; Cell Nucleus; Digestive System Diseases; Hepatocytes; Liver

    Research at a Glance

    Yale Co-Authors

    Frequent collaborators of Michael H Nathanson's published research.

    Publications

    2024

    2023

    2020

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    Clinical Trials

    Current Trials

    Academic Achievements & Community Involvement

    • activity

      VA

      CommitteesMember
    • activity

      NIH

      Peer Review Groups and Grant Study SectionsMember
    • activity

      NIH

      Peer Review Groups and Grant Study SectionsMember
    • activity

      AASLD

      CommitteesMember
    • honor

      Assoc of American Physicians (AAP)

      National Award
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    Clinical Care

    Overview

    Michael H. Nathanson, MD, PhD, specializes in treating patients with liver disease.

    He is a professor of medicine (digestive diseases) and of cell biology at Yale School of Medicine. In addition to his clinical work, he serves as co-director of the Yale Liver Center and director of the Center for Cellular and Molecular Imaging; he is also an active researcher.

    Clinical Specialties

    Internal Medicine; Hepatology

    Fact Sheets

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    Board Certifications

    • Internal Medicine

      Certification Organization
      AB of Internal Medicine
      Original Certification Date
      1988

    Yale Medicine News

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    Are You a Patient?

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    Get In Touch

    Contacts

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    Mailing Address

    Yale School of Medicine

    Department of Medicine (Digestive Diseases), PO Box 208019

    New Haven, CT 06520-8019

    United States

    Administrative Support

    Locations

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    Events

    Jan 20253Friday