2024
Association of Crowd-Sourced Assessment of Technical Skills and Outcomes of Robotic-assisted Radical Prostatectomy
Rabil M, Jalfon M, Heckscher D, Song Z, Li F, Martin T, Sprenkle P, Hesse D, Kim I, Leapman M, Cavallo J. Association of Crowd-Sourced Assessment of Technical Skills and Outcomes of Robotic-assisted Radical Prostatectomy. Urology 2024, 193: 87-94. PMID: 39019332, DOI: 10.1016/j.urology.2024.07.014.Peer-Reviewed Original ResearchRobotic-assisted laparoscopic prostatectomyCrowd-Sourced AssessmentGEARS scoreCrowd-sourced assessment of technical skillsRALP casesOutcomes of robot-assisted radical prostatectomyRobot-assisted radical prostatectomyExpert narrative reviewPelvic fluid collectionsPatient outcomesLikelihood of sepsisPost-operative outcomesAssociated with significant improvementsFellowship-trained urologistsAssessment of technical skillsRadical prostatectomyLaparoscopic prostatectomyAssociated with improvementsGlobal Evaluative AssessmentFluid collectionLogistic regression modelsSurgeon selectionPracticing surgeonsProstatectomySurgeons
2023
Disparities in immune and targeted therapy utilization for older US patients with metastatic renal cell carcinoma
Chow R, Long J, Hassan S, Wheeler S, Spees L, Leapman M, Hurwitz M, McManus H, Gross C, Dinan M. Disparities in immune and targeted therapy utilization for older US patients with metastatic renal cell carcinoma. JNCI Cancer Spectrum 2023, 7: pkad036. PMID: 37202354, PMCID: PMC10276895, DOI: 10.1093/jncics/pkad036.Peer-Reviewed Original ResearchConceptsOral anticancer agentsTherapy utilizationMedicare beneficiariesNon-Hispanic white raceMetastatic renal cell carcinomaNon-Hispanic black raceOlder US patientsUS Medicare beneficiariesRenal cell carcinomaLogistic regression modelsTherapy receiptMultivariable adjustmentSystemic therapyMale sexUS patientsCell carcinomaStudy criteriaBlack raceFemale sexPatient raceWhite raceImmunotherapyOutcomes persistSexPatients
2022
Acceptance of Simulated Adult Patients With Medicaid Insurance Seeking Care in a Cancer Hospital for a New Cancer Diagnosis
Marks VA, Hsiang WR, Nie J, Demkowicz P, Umer W, Haleem A, Galal B, Pak I, Kim D, Salazar MC, Berger ER, Boffa DJ, Leapman MS. Acceptance of Simulated Adult Patients With Medicaid Insurance Seeking Care in a Cancer Hospital for a New Cancer Diagnosis. JAMA Network Open 2022, 5: e2222214. PMID: 35838668, PMCID: PMC9287756, DOI: 10.1001/jamanetworkopen.2022.22214.Peer-Reviewed Original ResearchConceptsNew cancer diagnosesMedicaid insuranceCancer careAdult patientsSkin cancerComprehensive community cancer programsMultivariable logistic regression modelMedicaid acceptanceCancer-accredited facilitiesCancer diagnosisCommunity cancer programsBreast cancer carePopulation of patientsState Medicaid expansion statusCancer care servicesFacility-level factorsAbility of patientsAmerican Hospital Association Annual SurveyMedicaid expansion statusHigh-quality careLogistic regression modelsCancer HospitalCommon cancerFindings highlight gapsCancer programs
2019
Clinical risk-based associations of lymph node dissection and detection of metastasis among men treated with radical prostatectomy.
Abello A, Kenney P, Leapman M. Clinical risk-based associations of lymph node dissection and detection of metastasis among men treated with radical prostatectomy. Journal Of Clinical Oncology 2019, 37: 284-284. DOI: 10.1200/jco.2019.37.7_suppl.284.Peer-Reviewed Original ResearchPelvic lymph node dissectionLymph node countLymph node dissectionLymph node yieldRadical prostatectomyRisk strataNode dissectionNode yieldProstate Risk Assessment (CAPRA) scoreConditional logistic regression modelsRisk statusNational Cancer DatabaseHigh-risk patientsLymph node involvementProportion of patientsGroup of patientsLymph node metastasisDetection of metastasesCancer detection rateClinical risk statusRisk assessment scoreNode countLogistic regression modelsNode involvementPathologic factorsNational trends and pathologic outcomes of neoadjuvant chemotherapy among patients with micropapillary variant urothelial carcinoma of the bladder.
Javier-Desloges J, Abello A, Syed J, Leapman M. National trends and pathologic outcomes of neoadjuvant chemotherapy among patients with micropapillary variant urothelial carcinoma of the bladder. Journal Of Clinical Oncology 2019, 37: 477-477. DOI: 10.1200/jco.2019.37.7_suppl.477.Peer-Reviewed Original ResearchUse of NACUrothelial cell carcinomaReceipt of NACNeoadjuvant chemotherapyMicropapillary variantPathologic responseEntire cohortCell carcinomaClinical stage II diseasePropensity scoreVariant urothelial carcinomaNational Cancer DatabaseStage II diseaseComplete pathologic responsePathologic complete responseAggressive clinical behaviorLogistic regression modelsCT2 diseasePT0 rateComplete responsePathologic characteristicsRadical cystectomyDistant metastasisHistological diagnosisNAC use
2018
Association Between Prostate Magnetic Resonance Imaging and Observation for Low-risk Prostate Cancer
Leapman MS, Wang R, Park HS, Yu JB, Weinreb JC, Gross CP, Ma X. Association Between Prostate Magnetic Resonance Imaging and Observation for Low-risk Prostate Cancer. Urology 2018, 124: 98-106. PMID: 30107188, DOI: 10.1016/j.urology.2018.07.041.Peer-Reviewed Original ResearchConceptsLow-risk prostate cancerProstate magnetic resonance imagingMagnetic resonance imagingProstate cancerDefinitive treatmentPCa diagnosisEnd Results-Medicare databaseResonance imagingMultivariable logistic regression analysisPropensity scoreDiagnosis of PCaUse of MRIConditional logistic regression modelsLogistic regression analysisLogistic regression modelsInitial managementMultivariable analysisGreater oddsPatientsSocioeconomic statusDiagnosisHigher likelihoodRegression analysisDemographic factorsCancerOutcomes of serial MRI/ultrasound fusion targeted biopsy in men with very low-risk and low-risk prostate cancer managed with active surveillance.
Hsiang W, Ghabili K, Syed J, Nguyen K, Suarez-Sarmiento A, Leapman M, Sprenkle P. Outcomes of serial MRI/ultrasound fusion targeted biopsy in men with very low-risk and low-risk prostate cancer managed with active surveillance. Journal Of Clinical Oncology 2018, 36: 114-114. DOI: 10.1200/jco.2018.36.6_suppl.114.Peer-Reviewed Original ResearchMRI/US fusion biopsyLow-risk prostate cancerNational Comprehensive Cancer NetworkFusion biopsyActive surveillanceSystematic biopsyProstate cancerGleason upgradeMagnetic resonance imagingPSA densitySubsequent biopsyFavorable-risk prostate cancerMRI/ultrasound fusionSerial magnetic resonance imagingProportion of patientsRisk prostate cancerComprehensive Cancer NetworkLow-risk criteriaRisk of reclassificationLogistic regression modelsBiopsy upgradeMedian PSAGleason scoreHigher PSAInstitutional databaseNational determinants of active surveillance among patients with clinical stage 1A kidney tumors.
Lu A, Nguyen K, Nolte A, Alimi O, Hsiang W, Ghabili K, Syed J, Shuch B, Leapman M. National determinants of active surveillance among patients with clinical stage 1A kidney tumors. Journal Of Clinical Oncology 2018, 36: 694-694. DOI: 10.1200/jco.2018.36.6_suppl.694.Peer-Reviewed Original ResearchSmall renal massesNational Cancer DatabaseActive surveillanceInitial managementRenal massesCancer DatabaseClinical T1a renal massesMultivariate logistic regression modelFacility-level differencesWest North Central census divisionCancer registry dataT1a renal massesLogistic regression modelsSocio-demographic determinantsDefinitive therapyDefinitive treatmentPatient ageTotal cohortPractice patternsNational utilizationRegistry dataInclusion criteriaCaucasian raceKidney tumorsPatientsNational trends in the management of patients with positive surgical margins at the time of radical prostatectomy.
Ghabili K, Nguyen K, Hsiang W, Syed J, Suarez-Sarmiento A, Shuch B, Park H, Yu J, Leapman M. National trends in the management of patients with positive surgical margins at the time of radical prostatectomy. Journal Of Clinical Oncology 2018, 36: 111-111. DOI: 10.1200/jco.2018.36.6_suppl.111.Peer-Reviewed Original ResearchAdjuvant radiation therapyAndrogen deprivation therapyPositive surgical marginsNational Cancer DatabaseAdjuvant therapyRadical prostatectomyRadiation therapyProstate cancerPathologic featuresSurgical marginsAddition of ADTAdjuvant androgen deprivation therapyStudy periodPre-treatment PSAPrimary definitive treatmentMajority of patientsManagement of patientsGleason grade groupCourse of managementOptimal management approachNon-academic facilitiesLogistic regression modelsBinary logistic regression modelAnalysis menDeprivation therapy
2015
Association of magnitude of cancer of the prostate risk assessment score change following biopsy gleason upgrade during prostate cancer active surveillance with adverse pathology at prostatectomy.
Leapman M, Ameli N, Chu C, Welty C, Hussein A, Cooperberg M, Carroll P. Association of magnitude of cancer of the prostate risk assessment score change following biopsy gleason upgrade during prostate cancer active surveillance with adverse pathology at prostatectomy. Journal Of Clinical Oncology 2015, 33: 76-76. DOI: 10.1200/jco.2015.33.7_suppl.76.Peer-Reviewed Original ResearchCAPRA scoreActive surveillanceProstate cancerAdverse pathologyBiopsy GleasonProstate cancer active surveillanceIntermediate-risk prostate cancerProstate Risk Assessment (CAPRA) scoreRisk categoriesMultivariate logistic regression modelAdverse surgical pathologyRisk prostate cancerAdverse pathological outcomesRisk assessment scoreLogistic regression modelsBiopsy upgradeGleason upgradeSurveillance biopsiesMedian ageRepeat biopsyInitial diagnosisSubsequent biopsyRadical prostatectomyMedian changeSurgical pathology