2022
Rapidly enlarging pulmonary mass due to immune reconstitution inflammatory syndrome (IRIS) in an immunocompetent host with pulmonary Cryptococcus neoformans.
Tucker M, Sheikh AM, Villanueva MS. Rapidly enlarging pulmonary mass due to immune reconstitution inflammatory syndrome (IRIS) in an immunocompetent host with pulmonary Cryptococcus neoformans. BMJ Case Reports 2022, 15: e247495. PMID: 35351746, PMCID: PMC8966528, DOI: 10.1136/bcr-2021-247495.Peer-Reviewed Case Reports and Technical NotesConceptsImmune reconstitution inflammatory syndromeReconstitution inflammatory syndromeInflammatory syndromePulmonary massImmunocompetent hostsInitial induction courseLarge pulmonary massWeeks of fluconazoleLiposomal amphotericin BCritical vascular structuresInduction therapyImmunocompetent manInduction courseSecond courseAmphotericin BCryptococcus neoformansVascular structuresSignificant decreaseCryptococcomaSyndromeWeeksPrednisoneTherapyFlucytosineDisease
2018
A rare case of visceral leishmaniasis in an immunocompetent traveler returning to the United States from Europe
Haque L, Villanueva M, Russo A, Yuan Y, Lee EJ, Topal J, Podoltsev N. A rare case of visceral leishmaniasis in an immunocompetent traveler returning to the United States from Europe. PLOS Neglected Tropical Diseases 2018, 12: e0006727. PMID: 30286207, PMCID: PMC6171829, DOI: 10.1371/journal.pntd.0006727.Peer-Reviewed Case Reports and Technical NotesConceptsVisceral leishmaniasisHealthy travelersRare caseEndemic areasEndemic visceral leishmaniasisSuccessful initial treatmentLiposomal amphotericin BBone marrow biopsyImmunocompetent adultsImmunocompetent travelersNight sweatsImmunocompetent individualsInitial treatmentMarrow biopsyRelapseAmphotericin BPreventive measuresLeishmaniasisTreatmentUnited StatesExtensive experiencePancytopeniaSplenomegalyBiopsyPatientsFatal cryptococcal meningitis in an AIDS patient complicated with immune reconstitution syndrome refractory to prolonged amphotericin B treatment
Bandaranayake TD, Ogbuagu OE, Mahajan A, Vortmeyer AO, Villanueva MS. Fatal cryptococcal meningitis in an AIDS patient complicated with immune reconstitution syndrome refractory to prolonged amphotericin B treatment. International Journal Of STD & AIDS 2018, 29: 1250-1254. PMID: 29749873, DOI: 10.1177/0956462418773219.Peer-Reviewed Case Reports and Technical NotesConceptsCentral nervous system diseaseNervous system diseasesCryptococcal meningitisSystem diseasesSevere central nervous system diseaseFatal cryptococcal meningitisLiposomal amphotericin BAmphotericin B treatmentImmune recoveryPatient refractoryAntiretroviral therapyTherapeutic challengeTreatment failureAIDS patientsCystic lesionsFatal casesTreatment approachesMeningitisAmphotericin BC. neoformansMultiple coursesCryptococcus neoformansPatientsB treatmentDisease
2016
Meningitis Caused by Candida Dubliniensis in a Patient with Cirrhosis: A Case Report and Review of the Literature
Yamahiro A, Lau KH, Peaper DR, Villanueva M. Meningitis Caused by Candida Dubliniensis in a Patient with Cirrhosis: A Case Report and Review of the Literature. Mycopathologia 2016, 181: 589-593. PMID: 27038312, DOI: 10.1007/s11046-016-0006-7.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingPatient's mental statusMental statusSubstance use disordersLumbar punctureUse disordersHepatitis C virus-related cirrhosisC virus-related cirrhosisInitial cerebrospinal fluid (CSF) studiesEnd-stage liver diseaseHuman immunodeficiency virus (HIV) infectionBroad-spectrum antibiotic useImprovement of hydrocephalusMultiple lumbar puncturesSterilization of CSFIntravenous antibiotic therapyVirus-related cirrhosisCerebrospinal fluid studiesImmunodeficiency virus infectionInitiation of therapyLiposomal amphotericin BOptimal treatment strategyBroad-spectrum antibioticsCandida dubliniensisRecent chemotherapy