Featured Publications
Anti-Hypertensive Medications and Cardiovascular Events in Older Adults with Multiple Chronic Conditions
Tinetti ME, Han L, McAvay GJ, Lee DS, Peduzzi P, Dodson JA, Gross CP, Zhou B, Lin H. Anti-Hypertensive Medications and Cardiovascular Events in Older Adults with Multiple Chronic Conditions. PLOS ONE 2014, 9: e90733. PMID: 24614535, PMCID: PMC3948696, DOI: 10.1371/journal.pone.0090733.Peer-Reviewed Original ResearchConceptsMultiple chronic conditionsAnti-hypertensive treatmentCardiovascular eventsAnti-hypertensive medicationsHigh-intensity groupChronic conditionsOlder adultsHazard ratioPropensity scoreIntensity groupStandardized daily doseCommunity-living participantsPropensity score adjustmentCV eventsMedication intensityLess comorbidityDaily doseRandomized trialsMAIN OUTCOMERepresentative cohortScore adjustmentSurvey cohortRCT resultsCohortMortalityA Multifactorial Intervention to Reduce the Risk of Falling among Elderly People Living in the Community
Tinetti M, Baker D, McAvay G, Claus E, Garrett P, Gottschalk M, Koch M, Trainor K, Horwitz R. A Multifactorial Intervention to Reduce the Risk of Falling among Elderly People Living in the Community. New England Journal Of Medicine 1994, 331: 821-827. PMID: 8078528, DOI: 10.1056/nejm199409293311301.Peer-Reviewed Original ResearchConceptsRisk factorsIntervention groupControl groupPrescription medicationsAdjusted incidence rate ratioTargeted risk factorsUsual health careElderly peopleRisk factor modificationIncidence rate ratiosUse of sedativesTime of reassessmentYears of ageParticular risk factorsRange of motionProportion of personsPostural hypotensionMultifactorial interventionSerious morbidityExercise programGait impairmentBalance impairmentLeg strengthElderly personsMedications
2014
A Cluster-Randomized Controlled Trial of a Multicomponent Intervention Protocol for Pneumonia Prevention Among Nursing Home Elders
Juthani-Mehta M, Van Ness PH, McGloin J, Argraves S, Chen S, Charpentier P, Miller L, Williams K, Wall D, Baker D, Tinetti M, Peduzzi P, Quagliarello VJ. A Cluster-Randomized Controlled Trial of a Multicomponent Intervention Protocol for Pneumonia Prevention Among Nursing Home Elders. Clinical Infectious Diseases 2014, 60: 849-857. PMID: 25520333, PMCID: PMC4415071, DOI: 10.1093/cid/ciu935.Peer-Reviewed Original ResearchConceptsNursing home residentsUsual careHome residentsIntervention protocolFirst pneumoniaControl armClinical trialsNursing homesMultivariable Cox regression modelsElderly nursing home residentsCluster-randomized clinical trialImportant public health problemChlorhexidine oral rinseModifiable risk factorsRespiratory tract infectionsCox regression modelNursing home eldersPublic health problemHazard ratioPneumonia preventionSecondary outcomesTract infectionsControlled TrialsPrimary outcomeOral rinse
2008
Development of a Tool for Eliciting Patient Priority from Among Competing Cardiovascular Disease, Medication‐Symptoms, and Fall Injury Outcomes
Tinetti ME, McAvay GJ, Fried TR, Foody JM, Bianco L, Ginter S, Fraenkel L. Development of a Tool for Eliciting Patient Priority from Among Competing Cardiovascular Disease, Medication‐Symptoms, and Fall Injury Outcomes. Journal Of The American Geriatrics Society 2008, 56: 730-736. PMID: 18266842, PMCID: PMC3703614, DOI: 10.1111/j.1532-5415.2007.01627.x.Peer-Reviewed Original ResearchConceptsMedication symptomsFall injuriesIntraclass correlationCardiovascular disease outcomesMedication-related symptomsWilcoxon rank sum testRank sum testCVD outcomesCardiovascular diseaseDisease outcomePatient prioritiesSenior housing residentsSenior housing sitesInjury outcomesInjurySum testConvenience sampleRelative importance scores
1999
Drugs and Falls in Older People: A Systematic Review and Meta‐analysis: I. Psychotropic Drugs
Leipzig R, Cumming R, Tinetti M. Drugs and Falls in Older People: A Systematic Review and Meta‐analysis: I. Psychotropic Drugs. Journal Of The American Geriatrics Society 1999, 47: 30-39. PMID: 9920227, DOI: 10.1111/j.1532-5415.1999.tb01898.x.Peer-Reviewed Original ResearchConceptsPsychotropic drugsNeuroleptic useOlder peopleLong acting benzodiazepinesDuration of therapyIncidence of fallsNumber of fallersAdverse outcome eventsPooled odds ratioEnglish-language articlesIncreased fallsAntidepressant useHypnotic useMore fallsActing benzodiazepineBenzodiazepine useMean agePsychotropic usePooled ORsOdds ratioOutcome eventsTCA useExclusion criteriaEligibility criteriaResponse rateDrugs and Falls in Older People: A Systematic Review and Meta‐analysis: II. Cardiac and Analgesic Drugs
Leipzig R, Cumming R, Tinetti M. Drugs and Falls in Older People: A Systematic Review and Meta‐analysis: II. Cardiac and Analgesic Drugs. Journal Of The American Geriatrics Society 1999, 47: 40-50. PMID: 9920228, DOI: 10.1111/j.1532-5415.1999.tb01899.x.Peer-Reviewed Original ResearchConceptsPooled odds ratioAnalgesic drugsOdds ratioDiuretic useRecurrent fallsOlder peopleOlder adultsAnalgesic drug useNonnarcotic analgesic useDuration of therapyIncidence of fallsNumber of fallersCalcium channel blockersMean subject ageEnglish-language articlesDigoxin useNSAID useAnalgesic useAspirin useLoop diureticsMedication useThiazide diureticsNarcotic useACE inhibitorsMore falls
1991
Falls and Injuries in Frail and Vigorous Community Elderly Persons
Speechley M, Tinetti M. Falls and Injuries in Frail and Vigorous Community Elderly Persons. Journal Of The American Geriatrics Society 1991, 39: 46-52. PMID: 1987256, DOI: 10.1111/j.1532-5415.1991.tb05905.x.Peer-Reviewed Original ResearchConceptsElderly personsFrail subjectsCircumstances of fallsFall-related injuriesFrail elderly personsSerious health problemFrail groupFall circumstancesInjury preventionHealth problemsObserved incidencePreventive effortsInjurySerious injuriesFrailFallersVigorous groupSubjectsRepresentative sampleGroupPsychological variablesPersonsFallIncidenceTransition group